Search Results - "Iyappan, Anandhi"
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Using Multi-Scale Genetic, Neuroimaging and Clinical Data for Predicting Alzheimer’s Disease and Reconstruction of Relevant Biological Mechanisms
Published in Scientific reports (24-07-2018)“…Alzheimer’s Disease (AD) is among the most frequent neuro-degenerative diseases. Early diagnosis is essential for successful disease management and chance to…”
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Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment
Published in Bioinformatics (Oxford, England) (15-11-2017)“…The concept of a 'mechanism-based taxonomy of human disease' is currently replacing the outdated paradigm of diseases classified by clinical appearance. We…”
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Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models
Published in Journal of Alzheimer's disease (01-01-2017)“…Perturbance in inflammatory pathways have been identified as one of the major factors which leads to neurodegenerative diseases (NDD). Owing to the limited…”
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Neuroimaging Feature Terminology: A Controlled Terminology for the Annotation of Brain Imaging Features
Published in Journal of Alzheimer's disease (01-01-2017)“…Ontologies and terminologies are used for interoperability of knowledge and data in a standard manner among interdisciplinary research groups. Existing imaging…”
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Examining the healthy human microbiome concept
Published in Nature reviews. Microbiology (23-10-2024)“…Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and…”
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Towards a Pathway Inventory of the Human Brain for Modeling Disease Mechanisms Underlying Neurodegeneration
Published in Journal of Alzheimer's disease (01-01-2016)“…Molecular signaling pathways have been long used to demonstrate interactions among upstream causal molecules and downstream biological effects. They show the…”
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State of the art and the future of microbiome-based biomarkers: a multidisciplinary Delphi consensus
Published in The Lancet. Microbe (04-09-2024)“…Although microbiome signatures have been identified in various contexts (ie, pathogenesis of non-communicable diseases and treatment response), qualified…”
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NeuroRDF: semantic integration of highly curated data to prioritize biomarker candidates in Alzheimer's disease
Published in Journal of biomedical semantics (08-07-2016)“…Neurodegenerative diseases are incurable and debilitating indications with huge social and economic impact, where much is still to be learnt about the…”
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