Morbidity and Mortality Patterns of Hospitalised Adult HIV/AIDS Patients in the Era of Highly Active Antiretroviral Therapy: A 4-year Retrospective Review from Zaria, Northern Nigeria

Background. This study, undertaken in major tertiary hospital in northern Nigeria, examined the morbidity and mortality patterns of hospitalised adult HIV/AIDS patients in the HAART era. Methods. Between January 2006 and December 2009, admission records and causes of deaths of hospitalised medical H...

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Published in:	AIDS Research and Treatment Vol. 2012; no. 2012; pp. 705 - 714
Main Authors:	Ogoina, Dimie, Obiako, Reginald O., Muktar, Haruna M., Adeiza, Mukhtar, Babadoko, Aliyu, Hassan, Abdulaziz, Bansi, Isa, Iheonye, Henry, Iyanda, Matthew, Tabi-Ajayi, Eric
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Limiteds 2012 Hindawi Puplishing Corporation Hindawi Publishing Corporation Hindawi Limited
Subjects:	Acquired immune deficiency syndrome AIDS Antiretroviral drugs HIV Human immunodeficiency virus Mortality Tuberculosis
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Summary:	Background. This study, undertaken in major tertiary hospital in northern Nigeria, examined the morbidity and mortality patterns of hospitalised adult HIV/AIDS patients in the HAART era. Methods. Between January 2006 and December 2009, admission records and causes of deaths of hospitalised medical HIV-infected patients were retrieved and analysed according to antiretroviral (ART) status. Results. Of the 207 HIV/AIDS patients reviewed, majority were newly diagnosed (73.4%), and most were hospitalised and died from various AIDS-defining illnesses, mainly disseminated tuberculosis and sepsis. Immune-inflammatory-reconstitution-syndrome, ART-toxicity and ART-failure, contributed to morbidity and mortality in patients receiving ART. Sixty six (31.9%) patients died, with higher mortality in males and in those with lower CD4-cell count, lower PCV, and shorter hospital stay. However, hospital stay ≤3 days and severe anaemia (PCV < 24%) were independent predictors of mortality. Conclusion. In the current HAART era, late presentation and tuberculosis continue to fuel the HIV/AIDS pandemic in Africa, with emerging challenges due to ART-related complications.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Robin Wood
ISSN:	2090-1240 2090-1259
DOI:	10.1155/2012/940580