Search Results - "Iwig, David F."

A biodegradable thermoset polymer made by esterification of citric acid and glycerol by Halpern, Jeffrey M., Urbanski, Richard, Weinstock, Allison K., Iwig, David F., Mathers, Robert T., von Recum, Horst A.

“…A new biomaterial, a degradable thermoset polymer, was made from simple, economical, biocompatable monomers without the need for a catalyst. Glycerol and…”
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Characterization of RimO, a New Member of the Methylthiotransferase Subclass of the Radical SAM Superfamily by Lee, Kyung-Hoon, Saleh, Lana, Anton, Brian P, Madinger, Catherine L, Benner, Jack S, Iwig, David F, Roberts, Richard J, Krebs, Carsten, Booker, Squire J

“…RimO, encoded by the yliG gene in Escherichia coli, has been recently identified in vivo as the enzyme responsible for the attachment of a methylthio group on…”
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Discovery, structure and mechanism of a tetraether lipid synthase by Lloyd, Cody T., Iwig, David F., Wang, Bo, Cossu, Matteo, Metcalf, William W., Boal, Amie K., Booker, Squire J.

“…Archaea synthesize isoprenoid-based ether-linked membrane lipids, which enable them to withstand extreme environmental conditions, such as high temperatures,…”
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Isotope and Elemental Effects Indicate a Rate-Limiting Methyl Transfer as the Initial Step in the Reaction Catalyzed by Escherichia coli Cyclopropane Fatty Acid Synthase by Iwig, David F, Grippe, Anthony T, McIntyre, Timothy A, Booker, Squire J

“…Cyclopropane fatty acid (CFA) synthases catalyze the formation of cyclopropane rings on unsaturated fatty acids (UFAs) that are natural components of membrane…”
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The Activity of Escherichia coli Cyclopropane Fatty Acid Synthase Depends on the Presence of Bicarbonate by Iwig, David F, Uchida, Akira, Stromberg, Jeffrey A, Booker, Squire J

“…Cyclopropane fatty acid (CFA) synthases catalyze the formation of cyclopropane rings on isolated and unactivated olefinic bonds within various fatty acids; the…”
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Diglycerol-Based Polyesters: Melt Polymerization with Hydrophobic Anhydrides by Dakshinamoorthy, Deivasagayam, Weinstock, Allison K., Damodaran, Krishnan, Iwig, David F., Mathers, Robert T.

“…The melt polymerization of diglycerol with bicyclic anhydride monomers derived from a naturally occurring monoterpene provides an avenue for polyesters with a…”
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Enzymatic Fluoromethylation Enabled by the S‑Adenosylmethionine Analog Te-Adenosyl‑L‑(fluoromethyl)homotellurocysteine by Neti, Syam Sundar, Wang, Bo, Iwig, David F., Onderko, Elizabeth L., Booker, Squire J.

“…Fluoromethyl, difluoromethyl, and trifluoromethyl groups are present in numerous pharmaceuticals and agrochemicals, where they play critical roles in the…”
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Synthesis and Polymerization of Renewable 1,3‐Cyclohexadiene Using Metathesis, Isomerization, and Cascade Reactions with Late‐metal Catalysts by Mathers, Robert T., Shreve, Michael J., Meyler, Etan, Damodaran, Krishnan, Iwig, David F., Kelley, Diana J.

“…Synthesis and subsequent polymerization of renewable 1,3‐cyclohexadiene (1,3‐CHD) from plant oils is reported via metathesis and isomerization reactions. The…”
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Insight into the Polar Reactivity of the Onium Chalcogen Analogues of S-Adenosyl-l-methionine by Iwig, David F, Booker, Squire J

“…S-Adenosyl-l-methionine (AdoMet) is one of Nature's most diverse metabolites, used not only in a large number of biological reactions but amenable to several…”
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Lipoyl Synthase Requires Two Equivalents of S-Adenosyl-l-methionine To Synthesize One Equivalent of Lipoic Acid by Cicchillo, Robert M, Iwig, David F, Jones, A. Daniel, Nesbitt, Natasha M, Baleanu-Gogonea, Camelia, Souder, Matthew G, Tu, Loretta, Booker, Squire J

“…Lipoyl synthase (LipA) catalyzes the formation of the lipoyl cofactor, which is employed by several multienzyme complexes for the oxidative decarboxylation of…”
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Functionalization of polyesters with multiple B vitamins by Soxman, Andrew G., DeLuca, Jenna M., Kinlough, Kylie M., Iwig, David F., Mathers, Robert T.

“…ABSTRACT A method to covalently attach combinations of six different B vitamins provided an avenue to new functional thermosets without multi‐step coupling…”
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Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase by Nesbitt, Natasha M., Baleanu-Gogonea, Camelia, Cicchillo, Robert M., Goodson, Kathy, Iwig, David F., Broadwater, John A., Haas, Jeffrey A., Fox, Brian G., Booker, Squire J.

“…Lipoic acid is a sulfur-containing 8-carbon fatty acid that functions as a central cofactor in multienzyme complexes that are involved in the oxidative…”
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Facile Electron Transfer during Formation of Cluster X and Kinetic Competence of X for Tyrosyl Radical Production in Protein R2 of Ribonucleotide Reductase from Mouse by Yun, Danny, Krebs, Carsten, Gupta, Govind P, Iwig, David F, Huynh, Boi Hanh, Bollinger, J. Martin

“…The kinetics and mechanism of formation of the tyrosyl radical and μ-(oxo)diiron(III) cluster in the R2 subunit of ribonucleotide reductase from mouse have…”
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Incorporation of Nonmethyl Branches by Isoprenoid-like Logic: Multiple β-Alkylation Events in the Biosynthesis of Myxovirescin A1 by Calderone, Christopher T., Iwig, David F., Dorrestein, Pieter C., Kelleher, Neil L., Walsh, Christopher T.

“…Several polyketide secondary metabolites are predicted to undergo isoprenoid-like β-alkylations during biosynthesis. One such secondary metabolite is…”
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Investigation of the catalytic mechanism of the reaction catalyzed by Escherichia coli cyclopropane fatty acid synthase by Iwig, David F

“…Cyclopropane fatty acid (CFA) synthases catalyze the formation of cyclopropane rings from unsaturated fatty acids (UFAs) that are natural components of…”
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Investigation of the catalytic mechanism of the reaction catalyzed by Escherichia coli cyclopropane fatty acid synthase by Iwig, David F

“…Cyclopropane fatty acid (CFA) synthases catalyze the formation of cyclopropane rings from unsaturated fatty acids (UFAs) that are natural components of…”
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Incorporation of Non-Methyl Branches by Isoprenoid-Like Logic: Multiple β-Alkylation Events in the Biosynthesis of Myxovirescin A1 by Calderone, Christopher T., Iwig, David F., Dorrestein, Pieter C., Kelleher, Neil L., Walsh, Christopher T.

“…Several polyketide secondary metabolites are predicted to undergo isoprenoid-like β-alkylations during biosynthesis. One such secondary metabolite is…”
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