Search Results - "Iwatsubo, T"

Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer’s Disease by Budd Haeberlein, Samantha, Aisen, P.S., Barkhof, F., Chalkias, S., Chen, T., Cohen, S., Dent, G., Hansson, O., Harrison, K., von Hehn, C., Iwatsubo, T., Mallinckrodt, C., Mummery, C.J., Muralidharan, K.K., Nestorov, I., Nisenbaum, L., Rajagovindan, R., Skordos, L., Tian, Y., van Dyck, C.H., Vellas, B., Wu, S., Zhu, Y., Sandrock, A.

“…Background Alzheimer’s disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in…”
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Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease by Poulakis, Konstantinos, Pereira, Joana B., Muehlboeck, J.-Sebastian, Wahlund, Lars-Olof, Smedby, Örjan, Volpe, Giovanni, Masters, Colin L., Ames, David, Niimi, Yoshiki, Iwatsubo, Takeshi, Ferreira, Daniel, Westman, Eric

“…Understanding Alzheimer’s disease (AD) heterogeneity is important for understanding the underlying pathophysiological mechanisms of AD. However, AD atrophy…”
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Usability of a Web-Based Registry for Preclinical Alzheimer’s Disease: Implications from a Cross-Sectional Online Survey by Sato, Kenichiro, Niimi, Y., Ihara, R., Suzuki, K., Iwata, A., Iwatsubo, Takeshi

“…Background We have been conducting a Japanese trial-ready cohort web study since 2019 as a web-based online registry to enroll individuals with preclinical…”
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Tauroursodeoxycholic Acid Attenuates Diet-Induced and Age-Related Peripheral Endoplasmic Reticulum Stress and Cerebral Amyloid Pathology in a Mouse Model of Alzheimer’s Disease by Ochiai, T., Nagayama, T., Matsui, K., Amano, K., Sano, T., Wakabayashi, Tomoko, Iwatsubo, Takeshi

“…Background Obesity and diabetes are well-established risk factors of Alzheimer’s disease (AD). In the brains of patients with AD and model mice,…”
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Therapeutic Targets for Alzheimer’s Disease: Amyloid Vs. Non-Amyloid. Where Does Consensus Lie Today? An CTAD Task Force Report by Gauthier, Serge, Boxer, A., Knopman, D., Sims, J., Doody, R., Aisen, P., Iwatsubo, T., Bateman, R., Vellas, B.

“…There was consensus that both amyloid and tau pathologies should be targeted in Alzheimer’s disease, as well as additional pathophysiological mechanisms such…”
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Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin by Hayashi, I, Takatori, S, Urano, Y, Miyake, Y, Takagi, J, Sakata-Yanagimoto, M, Iwanari, H, Osawa, S, Morohashi, Y, Li, T, Wong, P C, Chiba, S, Kodama, T, Hamakubo, T, Tomita, T, Iwatsubo, T

“…Several lines of evidence suggest that aberrant Notch signaling contributes to the development of several types of cancer. Activation of Notch receptor is…”
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Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease by Chapuis, J, Hot, D, Hansmannel, F, Kerdraon, O, Ferreira, S, Hubans, C, Maurage, C A, Huot, L, Bensemain, F, Laumet, G, Ayral, A M, Fievet, N, Hauw, J J, DeKosky, S T, Lemoine, Y, Iwatsubo, T, Wavrant-Devrièze, F, Dartigues, J F, Tzourio, C, Buée, L, Pasquier, F, Berr, C, Mann, D, Lendon, C, Alpérovitch, A, Kamboh, M I, Amouyel, P, Lambert, J C

“…The only recognized genetic determinant of the common forms of Alzheimer's disease (AD) is the ɛ4 allele of the apolipoprotein E gene (APOE). To identify new…”
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Visual-statistical interpretation of (18)F-FDG-PET images for characteristic Alzheimer patterns in a multicenter study: inter-rater concordance and relationship to automated quantitative evaluation by Yamane, T, Ikari, Y, Nishio, T, Ishii, K, Kato, T, Ito, K, Silverman, D H S, Senda, M, Asada, T, Arai, H, Sugishita, M, Iwatsubo, T

“…The role of (18)F-FDG-PET in the diagnosis of Alzheimer disease is increasing and should be validated. The aim of this study was to assess the inter-rater…”
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Cohort-Specific Optimization of Models Predicting Preclinical Alzheimer’s Disease, to Enhance Screening Performance in the Middle of Preclinical Alzheimer’s Disease Clinical Studies by Sato, K., Mano, T., Ihara, R., Suzuki, K., Niimi, Y., Toda, T., Iwatsubo, T., Iwata, Atsushi

“…Background Models that can predict brain amyloid beta (Aβ) status more accurately have been desired to identify participants for clinical trials of preclinical…”
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Japanese Subgroup Analyses from EMERGE and ENGAGE, Phase 3 Clinical Trials of Aducanumab in Patients with Early Alzheimer’s Disease by Toda, Yasuo, Iwatsubo, T., Nakamura, Y., Matsuda, N., Miyata, M., Jin, M., Chen, T., Kuribayashi, K., Tian, Y., Hughes, R., Yamamoto, J., Muralidharan, K. K., Rubel, C., Hutchison, R. M., Haeberlein, S. Budd

“…Background Global prevalence and incidence of dementia continue to rise at a rapid rate. There is a need for new Alzheimer’s disease (AD) treatments globally…”
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Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver by Ito, K, Iwatsubo, T, Kanamitsu, S, Ueda, K, Suzuki, H, Sugiyama, Y

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Peripheral Blood BRCA1 Methylation Positively Correlates with Major Alzheimer’s Disease Risk Factors by Mano, Tatsuo, Sato, K., Ikeuchi, T., Toda, T., Iwatsubo, T., Iwata, A.

“…Background Recent biomarker studies demonstrated that the central nervous system (CNS) environment can be observed from peripherally-derived samples. In a…”
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Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies by Baba, M, Nakajo, S, Tu, PH, Tomita, T, Nakaya, K, Lee, VM, Trojanowski, JQ, Iwatsubo, T

“…Lewy bodies (LBs) are hallmark lesions of degenerating neurons in the brains of patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB)…”
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Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab by Mallinckrodt, C., Tian, Y., Aisen, P. S., Barkhof, F., Cohen, S., Dent, G., Hansson, O., Harrison, K., Iwatsubo, T., Mummery, C. J., Muralidharan, K. K., Nestorov, I., Nisenbaum, L., Rajagovindan, R., von Hehn, C., van Dyck, C. H., Vellas, B., Wu, S., Zhu, Y., Sandrock, A., Chen, T., Budd Haeberlein, Samantha

“…Objectives Efficacy and safety results from the EMERGE (NCT02484547) and ENGAGE (NCT02477800) phase 3 studies of aducanumab in early Alzheimer’s disease (AD)…”
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Using Digital Tools to Advance Alzheimer’s Drug Trials During a Pandemic: The EU/US CTAD Task Force by Kaye, Jeffrey, Aisen, P., Amariglio, R., Au, R., Ballard, C., Carrillo, M., Fillit, H., Iwatsubo, T., Jimenez-Maggiora, G., Lovestone, S., Natanegara, F., Papp, K., Soto, M. E., Weiner, M., Vellas, B.

“…The 2020 COVID-19 pandemic has disrupted Alzheimer’s disease (AD) clinical studies worldwide. Digital technologies may help minimize disruptions by enabling…”
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Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats by Umehara, K.-I., Iwatsubo, T., Noguchi, K., Kamimura, H.

“…The contribution of organic cation transporters to the saturable component in the hepatic uptake of 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium…”
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Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport by Ito, K, Iwatsubo, T, Kanamitsu, S, Nakajima, Y, Sugiyama, Y

“…It is of great importance to predict in vivo pharmacokinetics in humans based on in vitro data. We summarize recent findings of the quantitative prediction of…”
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Investigation of a colloidal damper by Suciu, C.V, Iwatsubo, T, Deki, S

“…A novel application of nanotechnology in the field of mechanical engineering, called colloidal damper (CD), is investigated. This device is complementary to…”
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Novel and global approach of the complex and interconnected phenomena related to the contact line movement past a solid surface from hydrophobized silica gel by Suciu, C.V., Iwatsubo, T., Yaguchi, K., Ikenaga, M.

“…In this work a generalized hydrodynamic theory for water flow into a mesoporous matrix from hydrophobized silica gel is suggested. Although we examine a fluid…”
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Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer’s disease by Wakutani, Y, Watanabe, K, Adachi, Y, Wada-Isoe, K, Urakami, K, Ninomiya, H, Saido, T C, Hashimoto, T, Iwatsubo, T, Nakashima, K

“…Objective: To describe a novel missense mutation, Asp678Asn (D678N), in the amyloid precursor protein (APP) gene in a Japanese pedigree of probable familial…”
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