Search Results - "Iwatani, Misa"

Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing by Araki, Shinsuke, Dairiki, Ryo, Nakayama, Yusuke, Murai, Aiko, Miyashita, Risa, Iwatani, Misa, Nomura, Toshiyuki, Nakanishi, Osamu

“…Accumulating evidence has demonstrated the importance of alternative splicing in various physiological processes, including the development of different…”
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A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells by Ishikawa, Yoshinori, Gamo, Kanae, Yabuki, Masato, Takagi, Shinji, Toyoshima, Kosei, Nakayama, Kazuhide, Nakayama, Akiko, Morimoto, Megumi, Miyashita, Hitoshi, Dairiki, Ryo, Hikichi, Yukiko, Tomita, Naoki, Tomita, Daisuke, Imamura, Shinichi, Iwatani, Misa, Kamada, Yusuke, Matsumoto, Satoru, Hara, Ryujiro, Nomura, Toshiyuki, Tsuchida, Ken, Nakamura, Kazuhide

“…Dysregulation of lysine (K)-specific demethylase 1A (LSD1), also known as KDM1A, has been implicated in the development of various cancers, including leukemia…”
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Dimethyl Sulfoxide Has an Impact on Epigenetic Profile in Mouse Embryoid Body by Iwatani, Misa, Ikegami, Kohta, Kremenska, Yuliya, Hattori, Naka, Tanaka, Satoshi, Yagi, Shintaro, Shiota, Kunio

“…Dimethyl sulfoxide (DMSO), an amphipathic molecule, is widely used not only as a solvent for water‐insoluble substances but also as a cryopreservant for…”
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Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability by Iwai, Kenichi, Yaguchi, Masahiro, Nishimura, Kazuho, Yamamoto, Yukiko, Tamura, Toshiya, Nakata, Daisuke, Dairiki, Ryo, Kawakita, Yoichi, Mizojiri, Ryo, Ito, Yoshiteru, Asano, Moriteru, Maezaki, Hironobu, Nakayama, Yusuke, Kaishima, Misato, Hayashi, Kozo, Teratani, Mika, Miyakawa, Shuichi, Iwatani, Misa, Miyamoto, Maki, Klein, Michael G, Lane, Wes, Snell, Gyorgy, Tjhen, Richard, He, Xingyue, Pulukuri, Sai, Nomura, Toshiyuki

“…The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy, especially for the cancers that exhibit aberrant pre‐mRNA splicing…”
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CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor by Funnell, Tyler, Tasaki, Shinya, Oloumi, Arusha, Araki, Shinsuke, Kong, Esther, Yap, Damian, Nakayama, Yusuke, Hughes, Christopher S., Cheng, S.-W. Grace, Tozaki, Hirokazu, Iwatani, Misa, Sasaki, Satoshi, Ohashi, Tomohiro, Miyazaki, Tohru, Morishita, Nao, Morishita, Daisuke, Ogasawara-Shimizu, Mari, Ohori, Momoko, Nakao, Shoichi, Karashima, Masatoshi, Sano, Masaya, Murai, Aiko, Nomura, Toshiyuki, Uchiyama, Noriko, Kawamoto, Tomohiro, Hara, Ryujiro, Nakanishi, Osamu, Shumansky, Karey, Rosner, Jamie, Wan, Adrian, McKinney, Steven, Morin, Gregg B., Nakanishi, Atsushi, Shah, Sohrab, Toyoshiba, Hiroyoshi, Aparicio, Samuel

“…CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent…”
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Genome‐wide and locus‐specific DNA hypomethylation in G9a deficient mouse embryonic stem cells by Ikegami, Kohta, Iwatani, Misa, Suzuki, Masako, Tachibana, Makoto, Shinkai, Yoichi, Tanaka, Satoshi, Greally, John M., Yagi, Shintaro, Hattori, Naka, Shiota, Kunio

“…In the mammalian genome, numerous CpG‐rich loci define tissue‐dependent and differentially methylated regions (T‐DMRs). Euchromatin from different cell types…”
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Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells by Sato, Shinya, Yagi, Shintaro, Arai, Yoshikazu, Hirabayashi, Keiji, Hattori, Naoko, Iwatani, Misa, Okita, Keisuke, Ohgane, Jun, Tanaka, Satoshi, Wakayama, Teruhiko, Yamanaka, Shinya, Shiota, Kunio

“…DNA methylation profile, consisting of tissue-dependent and differentially methylated regions (T-DMRs), has elucidated tissue-specific gene function in mouse…”
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Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos by Oda, Mayumi, Tanaka, Satoshi, Yamazaki, Yukiko, Ohta, Hiroshi, Iwatani, Misa, Suzuki, Masako, Ohgane, Jun, Hattori, Naka, Yanagimachi, Ryuzo, Wakayama, Teruhiko, Shiota, Kunio

“…Placental abnormalities occur frequently in cloned animals. Here, we attempted to isolate trophoblast stem (TS) cells from mouse blastocysts produced by…”
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Resistance to 5-aza-2'-deoxycytidine in Genic Regions Compared to Non-genic Repetitive Sequences by LIM, Hui Wen, IWATANI, Misa, HATTORI, Naoko, TANAKA, Satoshi, YAGI, Shintaro, SHIOTA, Kunio

“…The DNA methyltransferase (Dnmt) inhibitor and demethylating agent 5-aza-2'-deoxycytidine (5azadC) has been used to induce cellular differentiation and gene…”
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Discovery of spiro[indole-3,2′-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP by Ito, Masahiro, Iwatani, Misa, Yamamoto, Takeshi, Tanaka, Toshio, Kawamoto, Tomohiro, Morishita, Daisuke, Nakanishi, Atsushi, Maezaki, Hironobu

“…[Display omitted] Bad response to refrigeration 2 (Brr2) is a member of the Ski2-like RNA helicases, and an essential component of the U5 small nuclear…”
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T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice by Matsuda, Satoru, Baba, Rina, Oki, Hideyuki, Morimoto, Shinji, Toyofuku, Masashi, Igaki, Shigeru, Kamada, Yusuke, Iwasaki, Shinji, Matsumiya, Kota, Hibino, Ryosuke, Kamada, Hiroko, Hirakawa, Takeshi, Iwatani, Misa, Tsuchida, Ken, Hara, Ryujiro, Ito, Mitsuhiro, Kimura, Haruhide

“…Dysregulation of histone H3 lysine 4 (H3K4) methylation has been implicated in the pathogenesis of several neurodevelopmental disorders. Targeting…”
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Design, synthesis, and structure–activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects by Hattori, Yasushi, Matsumoto, Shigemitsu, Morimoto, Shinji, Daini, Masaki, Toyofuku, Masashi, Matsuda, Satoru, Baba, Rina, Murakami, Koji, Iwatani, Misa, Oki, Hideyuki, Iwasaki, Shinji, Matsumiya, Kouta, Tominari, Yusuke, Kimura, Haruhide, Ito, Mitsuhiro

“…Lysine-specific demethylase 1 (LSD1) is an enzyme that demethylates methylated histone H3 lysine 4 (H3K4). Inhibition of LSD1 enzyme activity could increase…”
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Discovery of selective ATP-competitive eIF4A3 inhibitors by Ito, Masahiro, Iwatani, Misa, Kamada, Yusuke, Sogabe, Satoshi, Nakao, Shoichi, Tanaka, Toshio, Kawamoto, Tomohiro, Aparicio, Samuel, Nakanishi, Atsushi, Imaeda, Yasuhiro

“…[Display omitted] Eukaryotic initiation factor 4A3 (eIF4A3), an ATP-dependent RNA helicase, is a core component of exon junction complex (EJC). EJC has a…”
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Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays by Nakao, Shoichi, Nogami, Masahiro, Iwatani, Misa, Imaeda, Toshihiro, Ito, Masahiro, Tanaka, Toshio, Tawada, Michiko, Endo, Satoshi, Cary, Douglas R., Ohori, Momoko, Imaeda, Yasuhiro, Kawamoto, Tomohiro, Aparicio, Samuel, Nakanishi, Atsushi, Araki, Shinsuke

“…The DEAD-box family of RNA helicases plays essential roles in both transcriptional and translational mRNA degradation; they unwind short double-stranded RNA by…”
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Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation by Arita, Takeo, Morimoto, Megumi, Yamamoto, Yukiko, Miyashita, Hitoshi, Kitazawa, Satoshi, Hirayama, Takaharu, Sakamoto, Sou, Miyamoto, Kazumasa, Adachi, Ryutaro, Iwatani, Misa, Hara, Takahito

“…Protein translation is highly activated in cancer tissues through oncogenic mutations and amplifications, and this can support survival and aberrant…”
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Discovery and characterization of novel allosteric FAK inhibitors by Iwatani, Misa, Iwata, Hidehisa, Okabe, Atsutoshi, Skene, Robert J., Tomita, Naoki, Hayashi, Yoko, Aramaki, Yoshio, Hosfield, David J., Hori, Akira, Baba, Atsuo, Miki, Hiroshi

“…Focal adhesion kinase (FAK) regulates cell survival and proliferation pathways. Here we report the discovery of a highly selective series of…”
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Structure-based discovery of cellular-active allosteric inhibitors of FAK by Tomita, Naoki, Hayashi, Yoko, Suzuki, Shinkichi, Oomori, Yoshimasa, Aramaki, Yoshio, Matsushita, Yoshihiro, Iwatani, Misa, Iwata, Hidehisa, Okabe, Atsutoshi, Awazu, Yoshiko, Isono, Osamu, Skene, Robert J., Hosfield, David J., Miki, Hiroshi, Kawamoto, Tomohiro, Hori, Akira, Baba, Atsuo

“…In order to develop potent and selective focal adhesion kinase (FAK) inhibitors, synthetic studies on pyrazolo[4,3-c][2,1]benzothiazines targeted for the FAK…”
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CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens by Ishii, Tsuyoshi, Okai, Takuro, Iwatani-Yoshihara, Misa, Mochizuki, Manabu, Unno, Satoko, Kuno, Masako, Yoshikawa, Masato, Shibata, Sachio, Nakakariya, Masanori, Yogo, Takatoshi, Kawamoto, Tomohiro

“…The proof of target engagement (TE) is a key element for evaluating potential investment in drug development. The cellular thermal shift assay (CETSA) is…”
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Estabishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos by Oda, Mayumi, Tanaka, Satoshi, Yamazaki, Yukiko, Ohta, Hiroshi, Iwatani, Misa, Suzuki, Masako, Ohgane, Jun, Hattori, Naka, Yanagimachi, Ryuzo, Wakayama, Teruhiko, Shiota, Kunio

“…Placental abnormalities occur frequently in cloned animals. Here, we attempted to isolate trophoblast stem (TS) cells from mouse blastocysts produced by…”
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Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors by Ito, Masahiro, Tanaka, Toshio, Cary, Douglas R, Iwatani-Yoshihara, Misa, Kamada, Yusuke, Kawamoto, Tomohiro, Aparicio, Samuel, Nakanishi, Atsushi, Imaeda, Yasuhiro

“…Eukaryotic initiation factor 4A3 (eIF4A3), a member of the DEAD-box RNA helicase family, is one of the core components of the exon junction complex (EJC). The…”
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