Search Results - "Iwano, Junko"

One-Step Conjugation Method for Site-Specific Antibody–Drug Conjugates through Reactive Cysteine-Engineered Antibodies by Shinmi, Daisuke, Taguchi, Eri, Iwano, Junko, Yamaguchi, Tsuyoshi, Masuda, Kazuhiro, Enokizono, Junichi, Shiraishi, Yasuhisa

“…Engineered cysteine residues are particularly convenient for site-specific conjugation of antibody–drug conjugates (ADC), because no cell engineering and…”
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Targeted delivery to macrophages and dendritic cells by chemically modified mannose ligand-conjugated siRNA by Uehara, Keiji, Harumoto, Toshimasa, Makino, Asana, Koda, Yasuo, Iwano, Junko, Suzuki, Yasuhiro, Tanigawa, Mari, Iwai, Hiroto, Asano, Kana, Kurihara, Kana, Hamaguchi, Akinori, Kodaira, Hiroshi, Atsumi, Toshiyuki, Yamada, Yoji, Tomizuka, Kazuma

“…Extrahepatic delivery of small interfering RNAs (siRNAs) may have applications in the development of novel therapeutic approaches. However, reports on such…”
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Impact of Different Selectivity between Soluble and Membrane-bound Forms of Carcinoembryonic Antigen (CEA) on the Target-mediated Disposition of Anti-CEA Monoclonal Antibodies by Iwano, Junko, Shinmi, Daisuke, Masuda, Kazuhiro, Murakami, Takashi, Enokizono, Junichi

“…Carcinoembryonic antigen (CEA) is a tumor-specific antigen overexpressed in multiple cancers. CEA is expressed as a membrane protein, a part of which is…”
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Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis by Mukai, Hidefumi, Hatanaka, Kentaro, Yagi, Nobuhiro, Warashina, Shota, Zouda, Maki, Takahashi, Maiko, Narushima, Kazuya, Yabuuchi, Hayato, Iwano, Junko, Kuboyama, Takeshi, Enokizono, Junichi, Wada, Yasuhiro, Watanabe, Yasuyoshi

“…In vivo biodistribution analyses, especially in tumors, of nucleic acids delivered with nanoparticles are important to develop drug delivery technologies for…”
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Development and evaluation of a novel antibody-photon absorber conjugate reveals the possibility of photoimmunotherapy-induced vascular occlusion during treatment in vivo by Isoda, Yuya, Piao, Wen, Taguchi, Eri, Iwano, Junko, Takaoka, Shigeki, Uchida, Aiko, Yoshikawa, Kiyomi, Enokizono, Junichi, Arakawa, Emi, Tomizuka, Kazuma, Shiraishi, Yasuhisa, Masuda, Kazuhiro

“…Photodynamic therapy (PDT) utilize a photosensitizing agent and light for cancer therapy. It exerts anti-cancer effect mainly by inducing vascular occlusion at…”
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Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity by Kajiwara, Moto, Terada, Tomohiro, Ogasawara, Ken, Iwano, Junko, Katsura, Toshiya, Fukatsu, Atsushi, Doi, Toshio, Inui, Ken-ichi

“…H(+)/organic cation antiporters (multidrug and toxin extrusion: MATE1 and MATE2-K) play important roles in the renal tubular secretion of cationic drugs. We…”
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Novel anticarcinoembryonic antigen antibody–drug conjugate has antitumor activity in the existence of soluble antigen by Shinmi, Daisuke, Nakano, Ryosuke, Mitamura, Keisuke, Suzuki‐Imaizumi, Minami, Iwano, Junko, Isoda, Yuya, Enokizono, Junichi, Shiraishi, Yasuhisa, Arakawa, Emi, Tomizuka, Kazuma, Masuda, Kazuhiro

“…Carcinoembryonic antigen (CEA) is a classic tumor‐specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti‐CEA…”
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