Search Results - "Iwanami, Norimasa"

Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1 by Nagakubo, Daisuke, Hirakawa, Mayumi, Iwanami, Norimasa, Boehm, Thomas

“…The development of the parathyroid and the thymus from the third pharyngeal pouch depends on the activities of the Gcm2 and Foxn1 transcription factors,…”
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Transgenerational inheritance of impaired larval T cell development in zebrafish by Iwanami, Norimasa, Lawir, Divine-Fondzenyuy, Sikora, Katarzyna, O´Meara, Connor, Takeshita, Kohei, Schorpp, Michael, Boehm, Thomas

“…Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Aberrant patterns of DNA methylation in gametes may set the…”
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Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells by Iwanami, Norimasa, Richter, Andreas S., Sikora, Katarzyna, Boehm, Thomas

“…Unconventional T cells, such as innate natural killer T cells (iNKT) cells, are an important part of vertebrate immune defences. iNKT recognise glycolipids…”
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Evolution of the Immune System in the Lower Vertebrates by Boehm, Thomas, Iwanami, Norimasa, Hess, Isabell

“…The evolutionary emergence of vertebrates was accompanied by the invention of adaptive immunity. This is characterized by extraordinarily diverse repertoires…”
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A small fish model for quantitative analysis of radiation effects using visualized thymus responses in GFP transgenic medaka by Maruyama, Kouichi, Iwanami, Norimasa, Maruyama-Hayakawa, Takako, Doi, Kazutaka, Wang, Bing

“…The aim of this study was to establish a new method of real-time, in vivo detection of radiation damage and recovery. The thymus was observed under fluorescent…”
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Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning by Hess, Isabell, Iwanami, Norimasa, Schorpp, Michael, Boehm, Thomas

“…Recent work on vertebrate hematopoiesis has uncovered the presence of deeply rooted similarities between fish and mammals at molecular and cellular levels…”
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Maturation of the medaka immune system depends on reciprocal interactions between the microbiota and the intestinal tract by Sakaguchi, Hiyori, Sato, Yuna, Matsumoto, Ryo, Gomikawa, Joe, Yoshida, Namie, Suzuki, Tomohiro, Matsuda, Masaru, Iwanami, Norimasa

“…The interactions between the host immune system and intestinal microorganisms have been studied in many animals, including fish. However, a detailed analysis…”
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Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles by Siamishi, Iliana, Iwanami, Norimasa, Clapes, Thomas, Trompouki, Eirini, O’Meara, Connor P., Boehm, Thomas

“…Immunodeficiencies are typically caused by loss-of-function mutations in lymphocyte-specific genes. Occasionally, mutations in ubiquitous general-purpose…”
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Clonal dynamics underlying the skewed CD4/CD8 ratio of mouse thymocytes revealed by TCR-independent barcoding by Iwanami, Norimasa, Petersen, Malte, Diekhoff, Dagmar, Boehm, Thomas

“…T cell differentiation in the thymus generates CD4 + helper and cytotoxic CD8 + cells as the two principal T cell lineages. Curiously, at the end of this…”
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Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys by Holland, Stephen J., Berghuis, Lesley M., King, Justin J., Iyer, Lakshminarayan M., Sikora, Katarzyna, Fifield, Heather, Peter, Sarah, Quinlan, Emma M., Sugahara, Fumiaki, Shingate, Prashant, Trancoso, Inês, Iwanami, Norimasa, Temereva, Elena, Strohmeier, Christine, Kuratani, Shigeru, Venkatesh, Byrappa, Evanno, Guillaume, Aravind, L., Schorpp, Michael, Larijani, Mani, Boehm, Thomas

“…Cytidine deaminases of the AID/APOBEC family catalyze C-to-U nucleotide transitions in mRNA or DNA. Members of the APOBEC3 branch are involved in antiviral…”
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Author Correction: Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish by Lawir, Divine-Fondzenyuy, Soza-Ried, Cristian, Iwanami, Norimasa, Siamishi, Iliana, Bylund, Göran O., O´Meara, Connor, Sikora, Katarzyna, Kanzler, Benoît, Johansson, Erik, Schorpp, Michael, Cauchy, Pierre, Boehm, Thomas

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Author Correction: Genetic landscape of T cells identifies synthetic lethality for T-ALL by O’Meara, Connor P., Guerri, Lucia, Lawir, Divine-Fondzenyuy, Mateos, Fernando, Iconomou, Mary, Iwanami, Norimasa, Soza-Ried, Cristian, Sikora, Katarzyna, Siamishi, Iliana, Giorgetti, Orlando, Peter, Sarah, Schorpp, Michael, Boehm, Thomas

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Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish by Lawir, Divine-Fondzenyuy, Soza-Ried, Cristian, Iwanami, Norimasa, Siamishi, Iliana, Bylund, Göran O., O´Meara, Connor, Sikora, Katarzyna, Kanzler, Benoît, Johansson, Erik, Schorpp, Michael, Cauchy, Pierre, Boehm, Thomas

“…The stability of cellular phenotypes in developing organisms depends on error-free transmission of epigenetic and genetic information during mitosis…”
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Cellular and molecular events during early thymus development by Holländer, Georg, Gill, Jason, Zuklys, Saulius, Iwanami, Norimasa, Liu, Cunlan, Takahama, Yousuke

“…The thymic stromal compartment consists of several cell types that collectively enable the attraction, survival, expansion, migration, and differentiation of…”
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Genetic landscape of T cells identifies synthetic lethality for T-ALL by O’Meara, Connor P., Guerri, Lucia, Lawir, Divine-Fondzenyuy, Mateos, Fernando, Iconomou, Mary, Iwanami, Norimasa, Soza-Ried, Cristian, Sikora, Katarzyna, Siamishi, Iliana, Giorgetti, Orlando, Peter, Sarah, Schorpp, Michael, Boehm, Thomas

“…To capture the global gene network regulating the differentiation of immature T cells in an unbiased manner, large-scale forward genetic screens in zebrafish…”
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Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1 by Iwanami, Norimasa, Takeshita, Kohei, Lawir, Divine-Fondzenyuy, Suetake, Isao, Tajima, Shoji, Sikora, Katarzyna, Trancoso, Inês, ÓMeara, Connor, Siamishi, Iliana, Takahama, Yousuke, Furutani-Seiki, Makoto, Kondoh, Hisato, Yonezawa, Yasushige, Schorpp, Michael, Boehm, Thomas

“…DNA methylation is a universal epigenetic mechanism involved in regulation of gene expression and genome stability. The DNA maintenance methylase DNMT1 ensures…”
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Noninvasive Intravital Imaging of Thymocyte Dynamics in Medaka by Li, Jie, Iwanami, Norimasa, Hoa, Vu Quynh, Furutani-Seiki, Makoto, Takahama, Yousuke

“…In vivo imaging of thymocytes has not been accomplished due to their localization deep within opaque body and high susceptibility to surgical stress. To…”
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Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency by Iwanami, Norimasa

“…Zebrafish is an important vertebrate model that provides the opportunity for the combination of genetic interrogation with advanced live imaging in the…”
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WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development by Iwanami, Norimasa, Higuchi, Tomokazu, Sasano, Yumi, Fujiwara, Toshinobu, Hoa, Vu Q, Okada, Minoru, Talukder, Sadiqur R, Kunimatsu, Sanae, Li, Jie, Saito, Fumi, Bhattacharya, Chitralekha, Matin, Angabin, Sasaki, Takashi, Shimizu, Nobuyoshi, Mitani, Hiroshi, Himmelbauer, Heinz, Momoi, Akihiro, Kondoh, Hisato, Furutani-Seiki, Makoto, Takahama, Yousuke

“…The thymus is a vertebrate-specific organ where T lymphocytes are generated. Genetic programs that lead to thymus development are incompletely understood. We…”
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Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease by Kawabata, Hiroyuki, Niwa, Atsuko, Tsuji-Kawahara, Sachiyo, Uenishi, Hirohide, Iwanami, Norimasa, Matsukuma, Hideaki, Abe, Hiroyuki, Tabata, Nobutada, Matsumura, Haruo, Miyazawa, Masaaki

“…CD8+ CTLs and virus-neutralizing antibodies have been associated with spontaneous and vaccine-induced immune control of retroviral infections. We previously…”
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