Search Results - "Iwamoto, Hiroaki"

Cleavage of C(sp3)–F Bonds in Trifluoromethylarenes Using a Bis(NHC)nickel(0) Complex by Iwamoto, Hiroaki, Imiya, Hiroto, Ohashi, Masato, Ogoshi, Sensuke

“…The first example of the oxidative addition of a C­(sp3)–F bond in trifluoromethylarenes to a nickel(0) complex is described. A nickel(0) complex that bears…”
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Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis by Kubota, Koji, Hayama, Keiichi, Iwamoto, Hiroaki, Ito, Hajime

“…The enantioselective borylative dearomatization of a heteroaromatic compound has been achieved using a copper(I) catalyst and a diboron reagent. This reaction…”
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Computational design of high-performance ligand for enantioselective Markovnikov hydroboration of aliphatic terminal alkenes by Iwamoto, Hiroaki, Imamoto, Tsuneo, Ito, Hajime

“…Finding optimal chiral ligands for transition-metal-catalyzed asymmetric reactions using trial-and-error methods is often time-consuming and costly, even if…”
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Conformationally Fixed Chiral Bisphosphine Ligands by Steric Modulators on the Ligand Backbone: Selective Synthesis of Strained 1,2-Disubstituted Chiral cis-Cyclopropanes by Iwamoto, Hiroaki, Ozawa, Yu, Hayashi, Yuta, Imamoto, Tsuneo, Ito, Hajime

“…A new series of C 1-symmetric P-chirogenic bisphosphine ligands of the type (R)-5,8-Si-Quinox-tBu3 (Silyl = SiMe3, SiEt3, SiMe2Ph) have been developed. The…”
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Is the C-C Motif Ligand 2-C-C Chemokine Receptor 2 Axis a Promising Target for Cancer Therapy and Diagnosis? by Iwamoto, Hiroaki, Izumi, Kouji, Mizokami, Atsushi

“…C-C motif ligand 2 (CCL2) was originally reported as a chemical mediator attracting mononuclear cells to inflammatory tissue. Many studies have reported that…”
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Copper(I)-Catalyzed Stereo- and Chemoselective Borylative Radical Cyclization of Alkyl Halides Bearing an Alkene Moiety by Iwamoto, Hiroaki, Akiyama, Sota, Hayama, Keiichi, Ito, Hajime

“…The stereoselective borylative radical cyclization of alkyl halides containing an alkene moiety was developed using a copper­(I)/diboron catalyst system. The…”
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Copper(I)‐Catalyzed Enantioconvergent Borylation of Racemic Benzyl Chlorides Enabled by Quadrant‐by‐Quadrant Structure Modification of Chiral Bisphosphine Ligands by Iwamoto, Hiroaki, Endo, Kohei, Ozawa, Yu, Watanabe, Yuta, Kubota, Koji, Imamoto, Tsuneo, Ito, Hajime

“…The first copper(I)‐catalyzed enantioselective borylation of racemic benzyl chlorides has been realized by a quadrant‐by‐quadrant structure modulation of…”
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Silicon-Tethered Strategy for Copper(I)-Catalyzed Stereo- and Regioselective Alkylboration of Alkynes by Kubota, Koji, Iwamoto, Hiroaki, Yamamoto, Eiji, Ito, Hajime

“…Stereoselective silicon-tethered alkylboration of alkynes in the presence of a copper(I) catalyst and a diboron reagent provided the corresponding cyclic…”
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Copper(I)-Catalyzed Regio- and Stereoselective Intramolecular Alkylboration of Propargyl Ethers and Amines by Iwamoto, Hiroaki, Ozawa, Yu, Kubota, Koji, Ito, Hajime

“…The copper­(I)-catalyzed regio- and stereoselective intramolecular alkylation of propargyl ethers and amines bearing an alkyl electrophilic moiety has been…”
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Copper(I)-catalyzed Diastereoselective Dearomative Carboborylation of Indoles by Hayama, Keiichi, Kubota, Koji, Iwamoto, Hiroaki, Ito, Hajime

“…The first C–B bond-forming dearomative carboborylation of heteroaromatic compounds has been achieved using copper(I) catalysis. This reaction includes the…”
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Investigating the mechanism underlying urinary continence using dynamic MRI after Retzius-sparing robot-assisted radical prostatectomy by Kadono, Yoshifumi, Nohara, Takahiro, Kawaguchi, Shohei, Kadomoto, Suguru, Iwamoto, Hiroaki, Iijima, Masashi, Shigehara, Kazuyoshi, Izumi, Kouji, Yoshida, Kotaro, Gabata, Toshifumi, Mizokami, Atsushi

“…Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) exhibits better postoperative urinary continence than conventional RARP (C-RARP) via the…”
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Editorial Comment to Omitting routine cystography after RARP: Analysis of complications and readmission rates in suprapubic and transurethral drained patients by Iwamoto, Hiroaki, Izumi, Kouji, Mizokami, Atsushi

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CCL2 induces resistance to the antiproliferative effect of cabazitaxel in prostate cancer cells by Natsagdorj, Ariunbold, Izumi, Kouji, Hiratsuka, Kaoru, Machioka, Kazuaki, Iwamoto, Hiroaki, Naito, Renato, Makino, Tomoyuki, Kadomoto, Suguru, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Lin, Wen‐Jye, Maolake, Aerken, Mizokami, Atsushi

“…Understanding the mechanism of chemoresistance and disease progression in patients with prostate cancer is important for developing novel treatment strategies…”
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Three-dimensional morphological analysis of spermatogenesis in aged mouse testes by Nakano, Taito, Nakata, Hiroki, Kadomoto, Suguru, Iwamoto, Hiroaki, Yaegashi, Hiroshi, Iijima, Masashi, Kawaguchi, Shohei, Nohara, Takahiro, Shigehara, Kazuyoshi, Izumi, Kouji, Kadono, Yoshifumi, Mizokami, Atsushi

“…Spermatogenesis, which is a continuous process from undifferentiated spermatogonia to spermatozoa in the seminiferous tubules, declines with age. To…”
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Tumor necrosis factor‐α induces prostate cancer cell migration in lymphatic metastasis through CCR7 upregulation by Maolake, Aerken, Izumi, Kouji, Natsagdorj, Ariunbold, Iwamoto, Hiroaki, Kadomoto, Suguru, Makino, Tomoyuki, Naito, Renato, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Hiratsuka, Kaoru, Wufuer, Guzailinuer, Nastiuk, Kent L., Mizokami, Atsushi

“…Understanding the mechanism of lymph node metastasis, a poor prognostic sign for prostate cancer, and the further dissemination of the disease is important to…”
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Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells by Makino, Tomoyuki, Izumi, Kouji, Hiratsuka, Kaoru, Kano, Hiroshi, Shimada, Takashi, Nakano, Taito, Kadomoto, Suguru, Naito, Renato, Iwamoto, Hiroaki, Yaegashi, Hiroshi, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Nakata, Hiroki, Saito, Yohei, Nakagawa-Goto, Kyoko, Sakai, Norihiko, Iwata, Yasunori, Wada, Takashi, Mizokami, Atsushi

“…Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown…”
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Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis by Maolake, Aerken, Izumi, Kouji, Shigehara, Kazuyoshi, Natsagdorj, Ariunbold, Iwamoto, Hiroaki, Kadomoto, Suguru, Takezawa, Yuta, Machioka, Kazuaki, Narimoto, Kazutaka, Namiki, Mikio, Lin, Wen-Jye, Wufuer, Guzailinuer, Mizokami, Atsushi

“…Previous studies have found that tumor-associated macrophages (TAMs) promote cancer progression. We previously reported that TAMs promote prostate cancer…”
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Suppression of androgen receptor signaling induces prostate cancer migration via activation of the CCL20–CCR6 axis by Kano, Hiroshi, Izumi, Kouji, Hiratsuka, Kaoru, Toriumi, Ren, Nakagawa, Ryunosuke, Aoyama, Shuhei, Kamijima, Taiki, Shimada, Takafumi, Naito, Renato, Kadomoto, Suguru, Iwamoto, Hiroaki, Yaegashi, Hiroshi, Kawaguchi, Shohei, Nohara, Takahiro, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Saito, Yohei, Nakagawa‐Goto, Kyoko, Yoshioka, Kazuaki, Nakata, Hiroki, Lin, Wen‐Jye, Mizokami, Atsushi

“…The suppression of androgen receptor (AR) expression exacerbates the migration potential of prostate cancer. This study identified a previously unrecognized…”
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Usefulness of serum CCL2 as prognostic biomarker in prostate cancer: a long-term follow-up study by Iwamoto, Hiroaki, Izumi, Kouji, Nakagawa, Ryunosuke, Toriumi, Ren, Aoyama, Shuhei, Shimada, Takafumi, Kano, Hiroshi, Makino, Tomoyuki, Kadomoto, Suguru, Yaegashi, Hiroshi, Kawaguchi, Shohei, Nohara, Takahiro, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Mizokami, Atsushi

“…Abstract Objective Prostate-specific antigen is considered the most useful biomarker for prostate cancer, but not in all cases. In a previous study, we have…”
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Synthesis of Fluoroalkyl Sulfides via Additive-Free Hydrothiolation and Sequential Functionalization Reactions by Sunagawa, Denise E, Ishida, Naoyoshi, Iwamoto, Hiroaki, Ohashi, Masato, Fruit, Corinne, Ogoshi, Sensuke

“…A modular synthetic method, involving a hydrothiolation, silylation, and fluoroalkylation, for the construction of highly functionalized fluoroalkyl sulfides…”
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