Search Results - "Iwamoto, Chika"

Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5 by Ando, Yohei, Ohuchida, Kenoki, Otsubo, Yoshiki, Kibe, Shin, Takesue, Shin, Abe, Toshiya, Iwamoto, Chika, Shindo, Koji, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Ohtsuka, Takao, Oda, Yoshinao, Nakamura, Masafumi

“…Necroptosis is a form of programmed cell death that is accompanied by release of intracellular contents, and reportedly contributes to various diseases. Here,…”
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Neutrophil extracellular traps promote liver micrometastasis in pancreatic ductal adenocarcinoma via the activation of cancer‑associated fibroblasts by Takesue, Shin, Ohuchida, Kenoki, Shinkawa, Tomohiko, Otsubo, Yoshiki, Matsumoto, Sokichi, Sagara, Akiko, Yonenaga, Akiko, Ando, Yohei, Kibe, Shin, Nakayama, Hiromichi, Iwamoto, Chika, Shindo, Koji, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Ohtsuka, Takao, Toma, Hiroki, Tominaga, Yohei, Mizumoto, Kazuhiro, Hashizume, Makoto, Nakamura, Masafumi

“…Cancer-associated fibroblasts (CAFs) promote the progression of pancreatic ductal adenocarcinoma (PDAC) via tumor-stromal interactions. Neutrophil…”
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Tumor-infiltrating monocytic myeloid-derived suppressor cells contribute to the development of an immunosuppressive tumor microenvironment in gastric cancer by Tsutsumi, Chikanori, Ohuchida, Kenoki, Katayama, Naoki, Yamada, Yutaka, Nakamura, Shoichi, Okuda, Sho, Otsubo, Yoshiki, Iwamoto, Chika, Torata, Nobuhiro, Horioka, Kohei, Shindo, Koji, Mizuuchi, Yusuke, Ikenaga, Naoki, Nakata, Kohei, Nagai, Eishi, Morisaki, Takashi, Oda, Yoshinao, Nakamura, Masafumi

“…Background Gastric cancer (GC) is characterized by an immunosuppressive and treatment-resistant tumor immune microenvironment (TIME). Here, we investigated the…”
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Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis by Yan, Zilong, Ohuchida, Kenoki, Fei, Shuang, Zheng, Biao, Guan, Weiyu, Feng, Haimin, Kibe, Shin, Ando, Yohei, Koikawa, Kazuhiro, Abe, Toshiya, Iwamoto, Chika, Shindo, Koji, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Ohtsuka, Takao, Mizumoto, Kazuhiro, Hashizume, Makoto, Nakamura, Masafumi

“…Extracellular signal-regulated kinases (ERKs) have been related to multiple cancers, including breast cancer, hepatocellular cancer, lung cancer and colorectal…”
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A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells by Jinnouchi, Fumiaki, Yamauchi, Takuji, Yurino, Ayano, Nunomura, Takuya, Nakano, Michitaka, Iwamoto, Chika, Obara, Teppei, Miyawaki, Kohta, Kikushige, Yoshikane, Kato, Koji, Maeda, Takahiro, Miyamoto, Toshihiro, Baba, Eishi, Akashi, Koichi, Takenaka, Katsuto

“…In human-to-mouse xenogeneic transplantation, polymorphisms of signal-regulatory protein α (SIRPA) that decide their binding affinity for human CD47 are…”
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Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses by Shinkawa, Tomohiko, Ohuchida, Kenoki, Mochida, Yuki, Sakihama, Kukiko, Iwamoto, Chika, Abe, Toshiya, Ideno, Noboru, Mizuuchi, Yusuke, Shindo, Koji, Ikenaga, Naoki, Moriyama, Taiki, Nakata, Kohei, Oda, Yoshinao, Nakamura, Masafumi

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma in which microenvironmental (niche) factors promote PDAC progression. In mouse…”
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Detection of pancreatic tumor cell nuclei via a hyperspectral analysis of pathological slides based on stain spectra by Ishikawa, Masahiro, Okamoto, Chisato, Shinoda, Kazuma, Komagata, Hideki, Iwamoto, Chika, Ohuchida, Kenoki, Hashizume, Makoto, Shimizu, Akinobu, Kobayashi, Naoki

“…Hyperspectral imaging (HSI) provides more detailed information than red-green-blue (RGB) imaging, and therefore has potential applications in computer-aided…”
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Dynamic glycolytic reprogramming effects on dendritic cells in pancreatic ductal adenocarcinoma by Zhang, Bo, Ohuchida, Kenoki, Tsutsumi, Chikanori, Shimada, Yuki, Mochida, Yuki, Oyama, Koki, Iwamoto, Chika, Sheng, Nan, Fei, Shuang, Shindo, Koji, Ikenaga, Naoki, Nakata, Kohei, Oda, Yoshinao, Nakamura, Masafumi

“…Pancreatic ductal adenocarcinoma tumors exhibit resistance to chemotherapy, targeted therapies, and even immunotherapy. Dendritic cells use glucose to support…”
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Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion by Kibe, Shin, Ohuchida, Kenoki, Ando, Yohei, Takesue, Shin, Nakayama, Hiromichi, Abe, Toshiya, Endo, Sho, Koikawa, Kazuhiro, Okumura, Takashi, Iwamoto, Chika, Shindo, Koji, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Shimamoto, Masaya, Ohtsuka, Takao, Mizumoto, Kazuhiro, Oda, Yoshinao, Nakamura, Masafumi

“…The pancreas is an organ prone to inflammation, fibrosis, and atrophy because of an abundance of acinar cells that produce digestive enzymes. A characteristic…”
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Adipose tissue‐derived stromal cells are sources of cancer‐associated fibroblasts and enhance tumor progression by dense collagen matrix by Okumura, Takashi, Ohuchida, Kenoki, Kibe, Shin, Iwamoto, Chika, Ando, Yohei, Takesue, Shin, Nakayama, Hiromichi, Abe, Toshiya, Endo, Sho, Koikawa, Kazuhiro, Sada, Masafumi, Horioka, Kohei, Mochidome, Naoki, Arita, Makoto, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Ohtsuka, Takao, Mizumoto, Kazuhiro, Oda, Yoshinao, Hashizume, Makoto, Nakamura, Masafumi

“…Although recent studies revealed that adipose tissue accelerates pancreatic tumor progression with excessive extracellular matrix, key players for desmoplasia…”
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Involvement of angiogenesis in cancer-associated acinar-to-ductal metaplasia lesion of pancreatic cancer invasive front by Fei, Shuang, Ohuchida, Kenoki, Kibe, Shin, Yan, Zilong, Iwamoto, Chika, Shinkawa, Tomohiko, Zhang, Bo, Kawata, Jun, Abe, Toshiya, Ideno, Noboru, Ikenaga, Naoki, Nakata, Kohei, Oda, Yoshinao, Nakamura, Masafumi

“…Purpose This study aimed to demonstrate the involvement of angiogenesis in cancer-associated acinar-to-ductal metaplasia (CA-ADM) lesion of invasive front…”
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Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment by Yamauchi, Takuji, Takenaka, Katsuto, Urata, Shingo, Shima, Takahiro, Kikushige, Yoshikane, Tokuyama, Takahito, Iwamoto, Chika, Nishihara, Mariko, Iwasaki, Hiromi, Miyamoto, Toshihiro, Honma, Nakayuki, Nakao, Miki, Matozaki, Takashi, Akashi, Koichi

“…Current mouse lines efficient for human cell xenotransplantation are backcrossed into NOD mice to introduce its multiple immunodeficient phenotypes. Our…”
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Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma by Luo, Haizhen, Ikenaga, Naoki, Nakata, Kohei, Higashijima, Nobuhiro, Zhong, Pingshan, Kubo, Akihiro, Wu, Chenyi, Tsutsumi, Chikanori, Shimada, Yuki, Hayashi, Masataka, Oyama, Koki, Date, Satomi, Abe, Toshiya, Ideno, Noboru, Iwamoto, Chika, Shindo, Koji, Ohuchida, Kenoki, Oda, Yoshinao, Nakamura, Masafumi

“…Tumor-associated neutrophils (TANs) constitute an abundant component among tumor-infiltrating immune cells and have recently emerged as a critical player in…”
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N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions by Feng, Haimin, Moriyama, Taiki, Ohuchida, Kenoki, Sheng, Nan, Iwamoto, Chika, Shindo, Koji, Shirahane, Kengo, Ikenaga, Naoki, Nagai, Shuntaro, Nakata, Kohei, Mizumoto, Kazuhiro, Nakamura, Masafumi

“…Pancreatic stellate cells (PSCs) occupy the majority of the pancreatic cancer microenvironment, contributing to aggressive behavior of pancreatic cancer cells…”
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Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180 by Koikawa, Kazuhiro, Ohuchida, Kenoki, Takesue, Shin, Ando, Yohei, Kibe, Shin, Nakayama, Hiromichi, Endo, Sho, Abe, Toshiya, Okumura, Takashi, Horioka, Kohei, Sada, Masafumi, Iwamoto, Chika, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Ohuchida, Riichi, Manabe, Tatsuya, Ohtsuka, Takao, Nagai, Eishi, Mizumoto, Kazuhiro, Hashizume, Makoto, Nakamura, Masafumi

“…Specific cell populations leading the local invasion of cancer are called “leading cells”. However, the underlying mechanisms are unclear. Here, we identified…”
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Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells by Zhong, PingShan, Nakata, Kohei, Oyama, Koki, Higashijima, Nobuhiro, Sagara, Akiko, Date, Satomi, Luo, HaiZhen, Hayashi, Masataka, Kubo, Akihiro, Wu, ChenYi, He, Shan, Yamamoto, Takeo, Koikawa, Kazuhiro, Iwamoto, Chika, Abe, Toshiya, Ikenaga, Naoki, Ohuchida, Kenoki, Morisaki, Takashi, Oda, Yoshinao, Kuba, Keiji, Nakamura, Masafumi

“…Although immune checkpoint blockade (ICB) therapy has proven to be extremely effective at managing certain cancers, its efficacy in treating pancreatic ductal…”
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Erratum to “ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway” [Pancreatology 22 (1) (2022 Jan) 9-19] by Guan, Weiyu, Nakata, Kohei, Sagara, Akiko, Iwamoto, Chika, Endo, Sho, Matsuda, Ryota, Matsumoto, Sokichi, Ikenaga, Naoki, Shindo, Koji, Moriyama, Taiki, Onishi, Hideya, Ohuchida, Kenoki, Oda, Yoshinao, Nakamura, Masafumi

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Postmortem interval estimation using the animal model of postmortem gas volume changes by Iwamoto, Chika, Ohuchida, Kenoki, Okumura, Miki, Usumoto, Yosuke, Kishimoto, Junji, Murata, Masaharu, Ikeda, Noriaki, Hashizume, Makoto

“…•The postmortem gas volume were calculated using time-dependent CT images.•The volume of postmortem portal venous gas rose exponentially with time after…”
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Repositioning of duloxetine to target pancreatic stellate cells by Sagara, Akiko, Nakata, Kohei, Matsumoto, Sokichi, Guan, Weiyu, Shinkawa, Tomohiko, Iwamoto, Chika, Ikenaga, Naoki, Ohuchida, Kenoki, Nakamura, Masafumi

“…Pancreatic cancer cells (PCCs) are surrounded by an abundant stroma, which is produced by pancreatic stellate cells (PSCs). PSCs promote tumor cell…”
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The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment by Iwamoto, Chika, Takenaka, Katsuto, Urata, Shingo, Yamauchi, Takuji, Shima, Takahiro, Kuriyama, Takuro, Daitoku, Shinya, Saito, Yasuyuki, Miyamoto, Toshihiro, Iwasaki, Hiromi, Kitabayashi, Issay, Itoh, Katsuhiko, Kishimoto, Junji, Kohda, Daisuke, Matozaki, Takashi, Akashi, Koichi

“…It has been shown that in xenotransplantation of human cells into immunodeficient mice, the mouse strain background is critical. For example, the nonobese…”
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