Search Results - "Iwakoshi, Neal N"

The transcription factor XBP-1 is essential for the development and survival of dendritic cells by Iwakoshi, Neal N, Pypaert, Marc, Glimcher, Laurie H

“…Dendritic cells (DCs) play a critical role in the initiation, maintenance, and resolution of an immune response. DC survival is tightly controlled by…”
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Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients by Burghuber, Christopher K., Manook, Miriam, Ezekian, Brian, Gibby, Adriana C., Leopardi, Frank V., Song, Minqing, Jenks, Jennifer, Saccoccio, Frances, Permar, Sallie, Farris, Alton B., Iwakoshi, Neal N., Kwun, Jean, Knechtle, Stuart J.

“…Previous evidence suggests that a homeostatic germinal center (GC) response may limit bortezomib desensitization therapy. We evaluated the combination of…”
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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response by Lee, Ann-Hwee, Iwakoshi, Neal N., Glimcher, Laurie H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes by Özcan, Umut, Cao, Qiong, Yilmaz, Erkan, Lee, Ann-Hwee, Iwakoshi, Neal N., Özdelen, Esra, Tuncman, Gürol, Görgün, Cem, Glimcher, Laurie H., Hotamisligil, Gökhan S.

“…Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show…”
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Proteasome Inhibitors Disrupt the Unfolded Protein Response in Myeloma Cells by Lee, Ann-Hwee, Iwakoshi, Neal N., Anderson, Kenneth C., Glimcher, Laurie H.

“…Novel agents that target the proteasome, a proteolytic complex responsible for the degradation of ubiquitinated proteins, have demonstrated remarkable…”
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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 by Glimcher, Laurie H, Iwakoshi, Neal N, Lee, Ann-Hwee, Vallabhajosyula, Prasanth, Otipoby, Kevin L, Rajewsky, Klaus

“…The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we…”
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XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation by Shaffer, A.L, Shapiro-Shelef, Miriam, Iwakoshi, Neal N, Lee, Ann-Hwee, Qian, Shu-Bing, Zhao, Hong, Yu, Xin, Yang, Liming, Tan, Bruce K, Rosenwald, Andreas, Hurt, Elaine M, Petroulakis, Emmanuel, Sonenberg, Nahum, Yewdell, Jonathan W, Calame, Kathryn, Glimcher, Laurie H, Staudt, Louis M

“…The differentiation of B cells into immunoglobulin-secreting plasma cells is controlled by two transcription factors, Blimp-1 and XBP1. By gene expression…”
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Plasma cell differentiation requires the transcription factor XBP-1 by Glimcher, Laurie H, Reimold, Andreas M, Iwakoshi, Neal N, Manis, John, Vallabhajosyula, Prashanth, Szomolanyi-Tsuda, Eva, Gravallese, Ellen M, Friend, Daniel, Grusby, Michael J, Alt, Frederick

“…Considerable progress has been made in identifying the transcription factors involved in the early specification of the B-lymphocyte lineage. However, little…”
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Viral-induced CD28 loss evokes costimulation independent alloimmunity by Mou, Danny, Espinosa, Jaclyn E, Stempora, Linda, Iwakoshi, Neal N., PhD, Kirk, Allan D., MD, PhD

“…Abstract Background Belatacept, a B7-specific fusion protein, blocks CD28-B7 costimulation and prevents kidney allograft rejection. However, it is ineffective…”
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The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response by Iwakoshi, Neal N., Lee, Ann-Hwee, Glimcher, Laurie H.

“…X‐box binding protein‐1 (XBP‐1) is a transcription factor essential for plasma cell differentiation. XBP‐1 transcripts are found at high levels in plasma cells…”
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Rapid Turnover of Unspliced Xbp-1 as a Factor That Modulates the Unfolded Protein Response by Tirosh, Boaz, Iwakoshi, Neal N., Glimcher, Laurie H., Ploegh, Hidde L.

“…The mammalian and yeast unfolded protein responses (UPR) share the characteristic of rapid elimination of unspliced Xbp-1 (Xbp-1u) and unspliced Hac1p,…”
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T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice by Espinosa, Jaclyn R, Mou, Danny, Adams, Bartley W, DiBernardo, Louis R, MacDonald, Andrea L, McRae, MacKenzie, Miller, Allison N, Song, Mingqing, Stempora, Linda L, Wang, Jun, Iwakoshi, Neal N, Kirk, Allan D

“…CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice…”
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Partial tolerance of autoreactive B and T cells to erythrocyte-specific self-antigens in mice by HUDSON, Krystalyn E, HENDRICKSON, Jeanne E, CADWELL, Chantel M, IWAKOSHI, Neal N, ZIMRING, James C

“…Breakdown of humoral tolerance to RBC antigens may lead to autoimmune hemolytic anemia, a severe and sometimes fatal disease. The underlying mechanisms behind…”
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XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells by Tirosh, Boaz, Iwakoshi, Neal N, Glimcher, Laurie H, Ploegh, Hidde L

“…Differentiation of B cells into plasma cells requires X-box binding protein-1 (XBP-1). In the absence of XBP-1, B cells develop normally, but very little…”
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XBP-1 and the unfolded protein response (UPR) by Glimcher, Laurie H., Lee, Ann-Hwee, Iwakoshi, Neal N.

“…Laurie Glimcher and colleagues recount their work that showed how the transcription factor XBP1 and the UPR signaling pathway are interconnected during plasma…”
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Author Correction: Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 by Iwakoshi, Neal N., Lee, Ann-Hwee, Vallabhajosyula, Prasanth, Otipoby, Kevin L., Rajewsky, Klaus, Glimcher, Laurie H.

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Human Cytomegalovirus Protein US11 Provokes an Unfolded Protein Response That May Facilitate the Degradation of Class I Major Histocompatibility Complex Products by TIROSH, Boaz, IWAKOSHI, Neal N, LILLEY, Brendan N, LEE, Ann-Hwee, GLIMCHER, Laurie H, PLOEGH, Hidde L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes by Liang, Xiaozhen, Collins, Christopher M, Mendel, Justin B, Iwakoshi, Neal N, Speck, Samuel H

“…Gammaherpesviruses chronically infect their host and are tightly associated with the development of lymphoproliferative diseases and lymphomas, as well as…”
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Author Correction: XBP-1 and the unfolded protein response (UPR) by Glimcher, Laurie H., Lee, Ann-Hwee, Iwakoshi, Neal N.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Bcl-xL Protein Protects from C/EBP Homologous Protein (CHOP)-dependent Apoptosis during Plasma Cell Differentiation by Gaudette, Brian T., Iwakoshi, Neal N., Boise, Lawrence H.

“…Although it is known that the unfolded protein response (UPR) plays a significant role in the process of plasma cell differentiation, the contribution of the…”
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