Search Results - "Ivry, Sam L."

Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH by Butler, Victoria J., Cortopassi, Wilian A., Argouarch, Andrea R., Ivry, Sam L., Craik, Charles S., Jacobson, Matthew P., Kao, Aimee W.

“…Single-copy loss-of-function mutations in the progranulin gene (PGRN) underlie the neurodegenerative disease frontotemporal lobar degeneration, while…”
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Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria by Goupil, Louise S, Ivry, Sam L, Hsieh, Ivy, Suzuki, Brian M, Craik, Charles S, O'Donoghue, Anthony J, McKerrow, James H

“…Proteases perform numerous vital functions in flatworms, many of which are likely to be conserved throughout the phylum Platyhelminthes. Within this phylum are…”
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Computational Kinetic Discrimination of Ethylene Polymerization Mechanisms for the Phillips (Cr/SiO2) Catalyst by Fong, Anthony, Yuan, Ye, Ivry, Sam L, Scott, Susannah L, Peters, Baron

“…The mechanism of ethylene polymerization by the widely used Phillips catalyst remains controversial. In this work, we compare initiation, propagation, and…”
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Global substrate specificity profiling of post‐translational modifying enzymes by Ivry, Sam L., Meyer, Nicole O., Winter, Michael B., Bohn, Markus F., Knudsen, Giselle M., O'Donoghue, Anthony J., Craik, Charles S.

“…Enzymes that modify the proteome, referred to as post‐translational modifying (PTM) enzymes, are central regulators of cellular signaling. Determining the…”
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Accurate Identification of Mucinous Pancreatic Cystic Lesions Using Small-Volume Analytes by Caiazza, Francesco, Conroy, Patricia C., Ivry, Sam L., York, Tyler, Lin, Joseph, Hernandez, Sophia, Hoffmann, Thomas J., Francis, Stephen S., Park, Walter G., Yip-Schneider, Michele T., Schmidt, C. Max, Brand, Randall, Craik, Charles S., Kirkwood, Kimberly

“…The accurate identification of mucinous pancreatic cystic lesions (PCLs) is paramount for cancer risk stratification. Cyst fluid carcinoembryonic antigen…”
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The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts by Ivry, Sam L, Knudsen, Giselle M, Caiazza, Francesco, Sharib, Jeremy M, Jaradeh, Katrin, Ravalin, Matthew, O'Donoghue, Anthony J, Kirkwood, Kimberly S, Craik, Charles S

“…Incidental detection of pancreatic cysts has increased dramatically over the last decade, but risk stratification and clinical management remain a challenge…”
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Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts by Ivry, Sam L, Sharib, Jeremy M, Dominguez, Dana A, Roy, Nilotpal, Hatcher, Stacy E, Yip-Schneider, Michele T, Schmidt, C Max, Brand, Randall E, Park, Walter G, Hebrok, Matthias, Kim, Grace E, O'Donoghue, Anthony J, Kirkwood, Kimberly S, Craik, Charles S

“…Pancreatic cysts are estimated to be present in 2%-3% of the adult population. Unfortunately, current diagnostics do not accurately distinguish benign cysts…”
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Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors by O'Donoghue, Anthony J, Ivry, Sam L, Chaudhury, Chaity, Hostetter, Daniel R, Hanahan, Douglas, Craik, Charles S

“…The cathepsin family of lysosomal proteases is increasingly being recognized for their altered expression in cancer and role in facilitating tumor progression…”
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Abstract 2226: Using functional biomarkers to accurately predict advanced neoplasia in pancreatic cystic lesions by Caiazza, Francesco, Lourenco, Andre, Conroy, Patricia, Hoffmann, Thomas, Ivry, Sam L., York, Tyler, Zhu, Gina, Mustoe, Audrey, O'Donoghue, Anthony J., Craik, Charles S., Kirkwood, Kimberly

“…Abstract Background: The accurate identification of high-grade dysplasia (HGD) or invasive cancer (advanced neoplasia, AN) in pancreatic cystic lesions (PCLs)…”
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