Search Results - "Ivison, Geoffrey T"
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Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability
Published in Journal of neuroinflammation (12-09-2021)“…Patients with chronic inflammatory disorders such as inflammatory bowel disease frequently experience neurological complications including epilepsy,…”
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Journal Article -
2
Dual blockade of the PI3K/Akt/mTOR pathway inhibits posttransplant Epstein‐Barr virus B cell lymphomas and promotes allograft survival
Published in American journal of transplantation (01-05-2019)“…Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation that often manifests as Epstein‐Barr virus…”
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Journal Article -
3
Natural Killer Cell Receptors and Ligands Are Associated With Markers of HIV-1 Persistence in Chronically Infected ART Suppressed Patients
Published in Frontiers in cellular and infection microbiology (10-02-2022)“…The latent HIV-1 reservoir represents a major barrier to achieving a long-term antiretroviral therapy (ART)-free remission or cure for HIV-1. Natural Killer…”
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Journal Article -
4
Mass Cytometry Phenotyping of Human Granulocytes Reveals Novel Basophil Functional Heterogeneity
Published in iScience (20-11-2020)“…Basophils, the rarest granulocyte, play critical roles in parasite- and allergen-induced inflammation. We applied mass cytometry (CyTOF) to simultaneously…”
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5
A single-cell atlas of the peripheral immune response in patients with severe COVID-19
Published in Nature medicine (01-07-2020)“…There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has…”
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6
An optimized protocol for phenotyping human granulocytes by mass cytometry
Published in STAR protocols (17-06-2022)“…Granulocytes encompass diverse roles, from fighting off pathogens to regulating inflammatory processes in allergies. These roles are represented by distinct…”
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Journal Article -
7
Substrate positioning by Gln(239) stimulates turnover in factor inhibiting HIF, an αKG-dependent hydroxylase
Published in Biochemistry (Easton) (16-09-2014)“…Nonheme Fe(II)/αKG-dependent oxygenases catalyze diverse reactions, typically inserting an O atom from O2 into a C-H bond. Although the key to their catalytic…”
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Journal Article -
8
Profiling of the Human Natural Killer Cell Receptor-Ligand Repertoire
Published in Journal of visualized experiments (19-11-2020)“…Natural killer (NK) cells are among the first responders to viral infections. The ability of NK cells to rapidly recognize and kill virally infected cells is…”
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Journal Article -
9
Substrate Positioning by Gln239 Stimulates Turnover in Factor Inhibiting HIF, an αKG-Dependent Hydroxylase
Published in Biochemistry (Easton) (16-09-2014)“…Nonheme Fe(II)/αKG-dependent oxygenases catalyze diverse reactions, typically inserting an O atom from O2 into a C–H bond. Although the key to their catalytic…”
Get full text
Journal Article -
10
Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNF[alpha] as mediators of neuronal hyperexcitability
Published in Journal of neuroinflammation (12-09-2021)“…Background Patients with chronic inflammatory disorders such as inflammatory bowel disease frequently experience neurological complications including epilepsy,…”
Get full text
Journal Article -
11
Substrate Positioning by Gln 239 Stimulates Turnover in Factor Inhibiting HIF, an αKG-Dependent Hydroxylase
Published in Biochemistry (Easton) (16-09-2014)Get full text
Journal Article -
12
Dual blockade of the PI3K/Akt/mTOR pathway inhibits post-transplant Epstein-Barr virus B cell lymphomas and promotes allograft survival
Published in American journal of transplantation (09-01-2019)“…Post-transplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation that often manifests as Epstein-Barr virus…”
Get full text
Journal Article -
13
Deep Profiling of Natural Killer Cells in Health and Disease
Published 01-01-2021“…Natural killer (NK) cells are innate immune cells with a crucial role in the early anti- viral and anti-cancer immune responses. In this thesis, I present two…”
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Dissertation