Paraoxonase 1 (PON1) and its relationship to lipid variables, age and gender in healthy volunteers

Paraoxonase 1 (PON1) and its relationship to lipid variables, age and gender in healthy volunteers

Recent studies implied that low-density lipoprotein (LDL) modified predominantly by oxidation or glycation, significantly contributes to the formation of atherosclerotic lesions. In contrast to oxidized LDL (ox-LDL), high-density lipoprotein (HDL) is able to prevent accumulation of ox-LDL in arteria...

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Bibliographic Details
Published in:Biológia Vol. 61; no. 6; pp. 699 - 704
Main Authors: Sumegová, Katarína, Pavel Blažíček, Bianca Fuhrman, Iveta WaczulíkovÃ, Zdeňka ĎuračkovÃ
Format: Journal Article
Language:English
Published: Versita 01-12-2006
Subjects:
aryldialkylphosphatase
arylesterase
arylesterase activity
atherosclerosis
blood lipids
blood serum
gender
glycation
high density lipoprotein cholesterol
high-density lipoprotein
low density lipoprotein
men
oxidation
paraoxonase 1
paraoxonase activity
women
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Summary:Recent studies implied that low-density lipoprotein (LDL) modified predominantly by oxidation or glycation, significantly contributes to the formation of atherosclerotic lesions. In contrast to oxidized LDL (ox-LDL), high-density lipoprotein (HDL) is able to prevent accumulation of ox-LDL in arterial walls. This antiatherogenic property of HDL is attributed in part to several enzymes associated with the lipoprotein, including HDL-associated paraoxonase 1 (PON1). In this study we analyzed PON1 arylesterase/paraoxonase activities in relation to serum lipid profile, gender and age in thirty clinically healthy Slovak volunteers. Our results showed that PON1 arylesterase and paraoxonase activities were lower in citrated plasma than in serum by 16.6% and 27.3%, respectively. Among serum lipoproteins, only HDL-cholesterol level showed significant positive correlation with PON1 arylesterase activity (p = 0.042). Likewise, we found a significant relationship between atherogenic index (AI = total cholesterol/HDL-cholesterol) and PON1 arylesterase activity (p = 0.023). No significant correlation could be demonstrated between PON1 paraoxonase activity and serum lipid profile, age or gender. Furthermore, it was found that PON1 paraoxonase/arylesterase activities were higher in women compared with both investigated activities in men, but these differences were not statistically significant. These results confirmed a positive correlation between HDL-cholesterol and PON1 arylesterase activity. Moreover, it was found out that PON1 paraoxonase activity is not influenced either by gender or by age. PON1 arylesterase activity was however affected by gender to a limited extent.
Bibliography:http://dx.doi.org/10.2478/s11756-006-0143-4
ISSN:1336-9563
0006-3088
1336-9563
DOI:10.2478/s11756-006-0143-4