Search Results - "Iversen, P.L"

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview by Abes, R, Arzumanov, A A, Moulton, H M, Abes, S, Ivanova, G D, Iversen, P L, Gait, M J, Lebleu, B

“…Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most…”
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Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo by Moulton, H M, Fletcher, S, Neuman, B W, McClorey, G, Stein, D A, Abes, S, Wilton, S D, Buchmeier, M J, Lebleu, B, Iversen, P L

“…The cellular uptake of PMOs (phosphorodiamidate morpholino oligomers) can be enhanced by their conjugation to arginine-rich CPPs (cell-penetrating peptides)…”
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T.P.2.10 Restoration of dystrophin expression in mdx mouse by peptide-conjugated antisense oligonucleotides by Yin, H.F, Seow, Y.Q, Moulton, H.M, Iversen, P.L, Boutilier, J.K, Wood, M.J.A

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West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions by Zhang, Bo, Dong, Hongping, Stein, David A, Iversen, Patrick L, Shi, Pei-Yong

“…Abstract West Nile virus (WNV) genome cyclization and replication require two pairs of long-distance RNA interactions. Besides the previously reported…”
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Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3′ stem–loop structure by Holden, Katherine Lynn, Stein, David A., Pierson, Theodore C., Ahmed, Asim A., Clyde, Karen, Iversen, Patrick L., Harris, Eva

“…Dengue virus (DEN) is a major public health problem worldwide and causes a spectrum of diseases, for which no antiviral treatments exist. Peptide-conjugated…”
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Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs by Ma, W, Lin, Y, Xuan, W, Iversen, P L, Smith, L J, Benchimol, S

“…The p53 tumor suppressor gene encodes a transcription factor that is commonly mutated in cancer. Tumors arise when premalignant cells are unable to undergo…”
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Induced dystrophin exon skipping in human muscle explants by McClorey, G., Fall, A.M., Moulton, H.M., Iversen, P.L., Rasko, J.E., Ryan, M., Fletcher, S., Wilton, S.D.

“…Antisense oligonucleotide (AO) manipulation of pre-mRNA splicing of the dystrophin gene is showing promise in overcoming Duchenne muscular dystrophy…”
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Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers by Zhang, Yan-Jin, Stein, David A., Fan, Su-Min, Wang, Kai-Yu, Kroeker, Andrew D., Meng, Xiang-Jin, Iversen, Patrick L., Matson, David O.

“…Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of a contagious disease characterized by reproductive failure in sows and…”
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Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function by Morse, M A, Hobeika, A, Serra, D, Aird, K, McKinney, M, Aldrich, A, Clay, T, Mourich, D, Lyerly, H K, Iversen, P L, Devi, G R

“…CD4+CD25+regulatory T cells (T reg ) impair anti-tumor and anti-viral immunity. As there are higher T reg levels in cancer patients compared with healthy…”
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Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture by Born, E. van den, Stein, D.A, Iversen, P.L, Snijder, E.J

“…The antiviral efficacy of ten antisense phosphorodiamidate morpholino oligomers (PMOs) directed against Equine arteritis virus (EAV), a nidovirus belonging to…”
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Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing by Marshall, N.B., Oda, S.K., London, C.A., Moulton, H.M., Iversen, P.L., Kerkvliet, N.I., Mourich, D.V.

“…Phosphorodiamidate morpholino oligomers (PMO) are synthetic antisense molecules that interfere with translation, pre-mRNA splicing and RNA synthesis. Like…”
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Virus-specific antiviral treatment for controlling severe and fatal outbreaks of feline calicivirus infection by Smith, A.W, Iversen, P.L, O'Hanley, P.D, Skilling, D.E, Christensen, J.R, Weaver, S.S, Longley, K, Stone, M.A, Poet, S.E, Matson, D.O

“…To test the life-sparing and therapeutic effect of a parenterally administered virus-specific antiviral phosphorodiamidate morpholino oligomer (PMO) for…”
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Isolation and characterization of a new Vesivirus from rabbits by Martín-Alonso, José M., Skilling, Douglas E., González-Molleda, Lorenzo, del Barrio, Gloria, Machín, Ángeles, Keefer, Nathan K., Matson, David O., Iversen, Patrick L., Smith, Alvin W., Parra, Francisco

“…This report describes the isolation, cDNA cloning, complete genome nucleotide sequence, and partial characterization of a new cultivable calicivirus isolated…”
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Transdermal delivery of antisense compounds by Brand, R.M, Iversen, P.L

“…Antisense technology holds tremendous promise for therapeutic applications and the study of gene function. A broadly applicable route of administration that…”
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Expression and regulation of brain metallothionein by Ebadi, M., Iversen, P.L., Hao, R., Cerutis, D.R., Rojas, P., Happe, H.K., Murrin, L.C., Pfeiffer, R.F.

“…Many, but not all, zinc-containing neurons in the brain are a subclass of the glutamatergic neurons, and they are found predominantly in the telencephalon…”
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Qualitative and quantitative measurements of oligonucleotides in gene therapy: Part I in vitro models by Tewary, H.K, Iversen, P.L

“…Part 1 of this review attempts to bring together all the methods of detection and determination of synthetic oligonucleotides used in in vitro, described in…”
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Qualitative and quantitative measurements of oligonucleotides in gene therapy: Part II in vivo models by Tewary, H.K., Iversen, P.L.

“…Part 1 of this review has already been presented on methods of processing and purification of crude or raw samples in cell-culture or cell free systems. Part…”
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Reaction between Metabolically Activated Acetaminophen and Phosphorothioate Oligonucleotides by Copple, B.L., Gmeiner, W.M., Iversen, P.L.

“…Assessment of toxic or mutagenic risks associated with phosphorothioate oligonucleotides (PTO) is important. In vitro and in vivo data have shown that PTOs are…”
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Selective changes in cytochrome P-450 and UDP-glucuronosyltransferase subpopulations following partial hepatectomy in rats by Iversen, P L, Liu, Z, Franklin, M R

“…Following 65% hepatectomy in adult male rats, the cytochrome P-450 in the residual liver decreased continuously from 1.0 to approximately 0.5 nmol/mg protein…”
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Structural details of the human cytochrome P-450c gene by Iversen, P L, Heiger, W J, Bresnick, E, Hines, R N

“…Aryl hydrocarbon hydroxylase activity is most closely associated with cytochrome P-450c in the rat and cytochrome P1-450 in the mouse. The sequence for the…”
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