Search Results - "Ivanusic, Jason J."

Changes to the activity and sensitivity of nerves innervating subchondral bone contribute to pain in late-stage osteoarthritis by Morgan, Michael, Thai, Jenny, Nazemian, Vida, Song, Richard, Ivanusic, Jason J.

“…Although it is clear that osteoarthritis (OA) pain involves activation and/or sensitization of nociceptors that innervate knee joint articular tissues, much…”
Get full text

Nerves in Bone: Evolving Concepts in Pain and Anabolism by Brazill, Jennifer M, Beeve, Alec T, Craft, Clarissa S, Ivanusic, Jason J, Scheller, Erica L

“…ABSTRACT The innervation of bone has been described for centuries, and our understanding of its function has rapidly evolved over the past several decades to…”
Get full text

Molecular Mechanisms That Contribute to Bone Marrow Pain by Ivanusic, Jason J

“…Pain associated a bony pathology puts a significant burden on individuals, society, and the health-care systems worldwide. Pathology that involves the bone…”
Get full text

GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain by Nencini, Sara, Ringuet, Mitchell, Kim, Dong-Hyun, Greenhill, Claire, Ivanusic, Jason J

“…Pain associated with skeletal pathology or disease is a significant clinical problem, but the mechanisms that generate and/or maintain it remain poorly…”
Get full text

The Physiology of Bone Pain. How Much Do We Really Know? by Nencini, Sara, Ivanusic, Jason J

“…Pain is associated with most bony pathologies. Clinical and experimental observations suggest that bone pain can be derived from noxious stimulation of the…”
Get full text

Size, neurochemistry, and segmental distribution of sensory neurons innervating the rat tibia by Ivanusic, Jason J.

“…Retrograde labeling has been used to identify sensory neurons in the lumbar dorsal root ganglia (DRG) that innervate the rat tibial periosteum, medullary…”
Get full text

The neurochemistry and morphology of functionally identified corneal polymodal nociceptors and cold thermoreceptors by Alamri, Abdulhakeem S, Wood, Rhiannon J, Ivanusic, Jason J, Brock, James A

“…It is generally believed that the unencapsulated sensory nerve terminals of modality specific C- and Aδ-neurons lack structural specialization. Here we…”
Get full text

Sensory and sympathetic innervation of the mouse and guinea pig corneal epithelium by Ivanusic, Jason J., Wood, Rhiannon J., Brock, James A.

“…This study used immunohistochemistry, retrograde tracing, and high‐resolution confocal microscopy to explore the structure and neurochemistry of nerve…”
Get full text

Mini review: The role of sensory innervation to subchondral bone in osteoarthritis pain by Morgan, Michael, Nazemian, Vida, Harrington, Kate, Ivanusic, Jason J

“…Osteoarthritis pain is often thought of as a pain driven by nerves that innervate the soft tissues of the joint, but there is emerging evidence for a role for…”
Get full text

Piezo2 Knockdown Inhibits Noxious Mechanical Stimulation and NGF-Induced Sensitization in A-Delta Bone Afferent Neurons by Nencini, Sara, Morgan, Michael, Thai, Jenny, Jobling, Andrew I., Mazzone, Stuart B., Ivanusic, Jason J.

“…Piezo2 is a mechanically gated ion-channel that has a well-defined role in innocuous mechanical sensitivity, but recently has also been suggested to play a…”
Get full text

N-Glycosylation Determines Ionic Permeability and Desensitization of the TRPV1 Capsaicin Receptor by Veldhuis, Nicholas A., Lew, Michael J., Abogadie, Fe C., Poole, Daniel P., Jennings, Ernest A., Ivanusic, Jason J., Eilers, Helge, Bunnett, Nigel W., McIntyre, Peter

“…The balance of glycosylation and deglycosylation of ion channels can markedly influence their function and regulation. However, the functional importance of…”
Get full text

The pattern of Fos expression in the spinal dorsal horn following acute noxious mechanical stimulation of bone by Ivanusic, Jason J

“…Abstract Little is known of the spinal mechanisms that mediate bone nociception. The aim of this study was to determine the pattern of neuronal activation in…”
Get full text

BDNF sensitizes bone and joint afferent neurons at different stages of MIA-induced osteoarthritis by Morgan, Michael, Nazemian, Vida, Thai, Jenny, Lin, Irene, Northfield, Susan, Ivanusic, Jason J.

“…There is emerging evidence that Brain Derived Neurotrophic Factor (BDNF), and one of its receptors TrkB, play important roles in the pathogenesis of…”
Get full text

TRPV1 activation alters the function of Aδ and C fiber sensory neurons that innervate bone by Morgan, Michael, Nencini, Sara, Thai, Jenny, Ivanusic, Jason J.

“…The Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a non-selective cation channel that is activated by capsaicin, low pH and…”
Get full text

Sequestration of artemin reduces inflammation‐induced activation and sensitization of bone marrow nociceptors in a rodent model of carrageenan‐induced inflammatory bone pain by Nencini, Sara, Thai, Jenny, Ivanusic, Jason J.

“…Background Pathologies that affect the bone marrow have a significant inflammatory component; however, it is not clear how inflammatory mediators affect…”
Get full text

Identifying spinal afferent (sensory) nerve endings that innervate the marrow cavity and periosteum using anterograde tracing by Thai, Jenny, Kyloh, Melinda, Travis, Lee, Spencer, Nick J., Ivanusic, Jason J.

“…While sensory and sympathetic neurons are known to innervate bone, previous studies have found it difficult to unequivocally identify and characterize only…”
Get full text

Distribution of Corneal TRPV1 and Its Association With Immune Cells During Homeostasis and Injury by Jiao, Haihan, Ivanusic, Jason J., McMenamin, Paul G., Chinnery, Holly R.

“…PurposeGiven the role of corneal sensory nerves during epithelial wound repair, we sought to examine the relationship between immune cells and polymodal…”
Get full text

Hyperpolarization-activated cyclic-nucleotide gated 4 (HCN4) protein is expressed in a subset of rat dorsal root and trigeminal ganglion neurons by Cho, Hyun-jung, Staikopoulos, Vasiliki, Ivanusic, Jason J, Jennings, Ernest A

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are active at resting membrane potential and thus are likely to contribute to…”
Get full text

TFOS DEWS II pain and sensation report by Belmonte, Carlos, Nichols, Jason J., Cox, Stephanie M., Brock, James A., Begley, Carolyn G., Bereiter, David A., Dartt, Darlene A., Galor, Anat, Hamrah, Pedram, Ivanusic, Jason J., Jacobs, Deborah S., McNamara, Nancy A., Rosenblatt, Mark I., Stapleton, Fiona, Wolffsohn, James S.

“…Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular surface is mediated by trigeminal ganglion neurons, while cold…”
Get full text

The evidence for the spinal segmental innervation of bone by Ivanusic, Jason J.

“…Dermatomes and myotomes are areas of skin and muscle, respectively, that are innervated by single spinal segmental nerves, and reflect a principle of…”
Get full text