Endothelial function in patients with and without diabetes mellitus with different degrees of coronary artery stenosis

Purpose. To evaluate endothelial function using flow‐mediated dilatation (FMD) of the brachial artery in patients with and without diabetes mellitus (DM) with different degrees of coronary artery stenosis. Method. We investigated 293 patients, 69 (23.6%) of whom had DM. FMD and coronary arteriograph...

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Bibliographic Details
Published in:	Journal of clinical ultrasound Vol. 37; no. 1; pp. 35 - 39
Main Authors:	Simova, Iana I., Denchev, Stefan V., Dimitrov, Simeon I., Ivanova, Raia
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-01-2009
Subjects:	Aged atherosclerosis Blood Flow Velocity Brachial Artery - physiopathology Coronary Stenosis - complications Coronary Stenosis - physiopathology diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology endothelial dysfunction Endothelium, Vascular - physiopathology Female flow mediated dilatation Humans Male Middle Aged Risk Factors Severity of Illness Index
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Summary:	Purpose. To evaluate endothelial function using flow‐mediated dilatation (FMD) of the brachial artery in patients with and without diabetes mellitus (DM) with different degrees of coronary artery stenosis. Method. We investigated 293 patients, 69 (23.6%) of whom had DM. FMD and coronary arteriography were performed. Results. Patients with DM had a significantly lower FMD (mean ± SD, 3.7 ± 3.8%) compared with patients without DM (mean ± SD, 5.2 ± 5.3%) (p < 0.05). When the results were broken down by the severity of coronary artery disease (CAD) (no significant coronary artery stenosis, 1‐vessel disease, 2‐vessel disease, and 3‐vessel disease) the only statistically significant difference between diabetics and nondiabetics was found in patients without significant coronary stenosis (mean FMD ± SD: 5.2 ± 4.4% in diabetics, 7.6 ± 5.4% in nondiabetics [p < 0.05]). Conclusion. In CAD patients, the presence of DM was associated with endothelial dysfunction. The difference in the FMD was clearly expressed between patients with and without DM in the subgroup without significant coronary stenosis, and was no longer present with advanced coronary atherosclerosis. © 2008 Wiley Periodicals, Inc. J Clin Ultrasound, 2009
Bibliography:	istex:F7DFBDC773E3865A9B376A1DE42E5F5BE5955639 ArticleID:JCU20532 ark:/67375/WNG-43DMW7XP-W ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0091-2751 1097-0096
DOI:	10.1002/jcu.20532