Search Results - "Ivanov, Nikolai"
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Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence
Published in Nucleic acids research (04-06-2020)“…BREX (for BacteRiophage EXclusion) is a superfamily of common bacterial and archaeal defence systems active against diverse bacteriophages. While the mechanism…”
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Natural and induced variations in transcriptional regulator genes result in low‐nicotine phenotypes in tobacco
Published in The Plant journal : for cell and molecular biology (01-09-2022)“…SUMMARY In tobacco, the homologous ETHYLENE RESPONSE FACTOR (ERF) transcription factors ERF199 and ERF189 coordinate the transcription of multiple metabolic…”
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Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
Published in Cell reports (Cambridge) (29-08-2023)“…Bacteriophage T3 encodes a SAMase that, through cleavage of S-adenosyl methionine (SAM), circumvents the SAM-dependent type I restriction-modification (R-M)…”
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The tobacco genome sequence and its comparison with those of tomato and potato
Published in Nature communications (08-05-2014)“…The allotetraploid plant Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences are…”
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Oil-Membrane Protection of Electrochemical Sensors for Fouling- and pH-Insensitive Detection of Lipophilic Analytes
Published in ACS applied materials & interfaces (17-11-2021)“…To take full advantage of the reagent- and label-free sensing capabilities of electrochemical sensors, a frequent and remaining challenge is interference and…”
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Alkaloid chemophenetics and transcriptomics of the Nicotiana genus
Published in Phytochemistry (Oxford) (01-09-2020)“…In this study, we determined the pyridine alkaloid content (nicotine, nornicotine, anabasine, anatabine, cotinine, and myosmine) of 58 species and 2 subspecies…”
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Genomic Insights into the Evolution of the Nicotine Biosynthesis Pathway in Tobacco
Published in Plant physiology (Bethesda) (01-06-2017)“…In tobacco (Nicotiana tabacum), nicotine is the predominant alkaloid. It is produced in the roots and accumulated mainly in the leaves. Jasmonates play a…”
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Lipid-based biomarkers for CVD, COPD, and aging – A translational perspective
Published in Progress in lipid research (01-04-2020)“…For many diseases, there is an unmet need for new or better biomarkers for improved disease risk assessment and monitoring, as available markers lack…”
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Acclimation strategies of the green alga Chlorella vulgaris to different light regimes revealed by physiological and comparative proteomic analyses
Published in Journal of experimental botany (17-08-2023)“…Abstract Acclimation to different light regimes is at the basis of survival for photosynthetic organisms, regardless of their evolutionary origin. Previous…”
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Shotgun Lipidomics of Rodent Tissues
Published in Journal of visualized experiments (18-11-2022)“…Lipids play a vital role as essential components of all prokaryotic and eukaryotic cells. Constant technological improvements in mass spectrometry have made…”
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A 6-month systems toxicology inhalation study in ApoE -/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke
Published in American journal of physiology. Heart and circulatory physiology (01-03-2020)“…Smoking cigarettes is harmful to the cardiovascular system. Considerable attention has been paid to the reduced harm potential of alternative…”
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BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site
Published in Nucleic acids research (10-01-2019)“…Abstract Prokaryotes evolved numerous systems that defend against predation by bacteriophages. In addition to well-known restriction-modification and…”
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Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties
Published in Food and chemical toxicology (01-10-2019)“…Within the traditional pharmacopeia, tobacco (Nicotiana spp.) is often cited as an efficient pesticide. This activity is generally attributed to nicotine, but…”
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Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification
Published in International journal of molecular sciences (15-09-2018)“…Inflammatory bowel disease (IBD) represents a group of progressive disorders characterized by recurrent chronic inflammation of the gut. Ulcerative colitis and…”
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Fractionation and Extraction Optimization of Potentially Valuable Compounds and Their Profiling in Six Varieties of Two Nicotiana Species
Published in Molecules (Basel, Switzerland) (21-11-2022)“…There is an increasingly urgent call to shift industrial processes from fossil fuel feedstock to sustainable bio-based resources. This change becomes of high…”
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Interrogating the microbiome: experimental and computational considerations in support of study reproducibility
Published in Drug discovery today (01-09-2018)“…[Display omitted] •Growing evidence indicates that the microbiome plays an important role in health and disease.•Reliable and meaningful scientific conclusions…”
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Identification of Granatane Alkaloids from Duboisia myoporoides (Solanaceae) using Molecular Networking and Semisynthesis
Published in Journal of natural products (Washington, D.C.) (23-08-2024)“…The Solanaceae plant family contains at least 98 genera and over 2700 species. The Duboisia genus stands out for its ability to produce pyridine and tropane…”
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Chromosome-scale assemblies of S. malaccense, S. aqueum, S. jambos, and S. syzygioides provide insights into the evolution of Syzygium genomes
Published in Frontiers in plant science (06-10-2023)“…Syzygium is a large and diverse tree genus in the Myrtaceae family. Genome assemblies for clove ( Syzygium aromaticum , 370 Mb) and sea apple ( Syzygium grande…”
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Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking
Published in Chemical research in toxicology (17-04-2023)“…Tobacco smoke delivers a complex mixture of hazardous and potentially hazardous chemicals. Some of these may induce the formation of DNA mutations, which…”
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Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge
Published in BMC genomics (30-08-2022)“…Abstract Background Selection of optimal computational strategies for analyzing metagenomics data is a decisive step in determining the microbial composition…”
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