Search Results - "Ivanek, Robert"

Visualizing Genomic Data Using Gviz and Bioconductor by Hahne, Florian, Ivanek, Robert

“…The Gviz package offers a flexible framework to visualize genomic data in the context of a variety of different genome annotation features. Being tightly…”
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Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells by Rodrigues, Patrick Fernandes, Alberti-Servera, Llucia, Eremin, Anna, Grajales-Reyes, Gary E., Ivanek, Robert, Tussiwand, Roxane

“…Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts of type 1 interferons in response to viral infections…”
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Distinct contributions of partial and full EMT to breast cancer malignancy by Lüönd, Fabiana, Sugiyama, Nami, Bill, Ruben, Bornes, Laura, Hager, Carolina, Tang, Fengyuan, Santacroce, Natascha, Beisel, Christian, Ivanek, Robert, Bürglin, Thomas, Tiede, Stefanie, van Rheenen, Jacco, Christofori, Gerhard

“…Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-differentiation where cancer cells transit between various stages of an…”
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Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions by Feldmann, Angelika, Ivanek, Robert, Murr, Rabih, Gaidatzis, Dimos, Burger, Lukas, Schübeler, Dirk

“…Distal regulatory elements, including enhancers, play a critical role in regulating gene activity. Transcription factor binding to these elements correlates…”
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A Hierarchical Regulatory Landscape during the Multiple Stages of EMT by Meyer-Schaller, Nathalie, Cardner, Mathias, Diepenbruck, Maren, Saxena, Meera, Tiede, Stefanie, Lüönd, Fabiana, Ivanek, Robert, Beerenwinkel, Niko, Christofori, Gerhard

“…Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming…”
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DNA-binding factors shape the mouse methylome at distal regulatory regions by Stadler, Michael B., Murr, Rabih, Burger, Lukas, Ivanek, Robert, Lienert, Florian, Schöler, Anne, Nimwegen, Erik van, Wirbelauer, Christiane, Oakeley, Edward J., Gaidatzis, Dimos, Tiwari, Vijay K., Schübeler, Dirk

“…Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet the rules that govern methylation patterns remain largely elusive…”
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Mutations in DNAJC5, Encoding Cysteine-String Protein Alpha, Cause Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis by Nosková, Lenka, Stránecký, Viktor, Hartmannová, Hana, Přistoupilová, Anna, Barešová, Veronika, Ivánek, Robert, Hůlková, Helena, Jahnová, Helena, van der Zee, Julie, Staropoli, John F., Sims, Katherine B., Tyynelä, Jaana, Van Broeckhoven, Christine, Nijssen, Peter C.G., Mole, Sara E., Elleder, Milan, Kmoch, Stanislav

“…Autosomal-dominant adult-onset neuronal ceroid lipofuscinosis (ANCL) is characterized by accumulation of autofluorescent storage material in neural tissues and…”
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miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis by Diepenbruck, Maren, Tiede, Stefanie, Saxena, Meera, Ivanek, Robert, Kalathur, Ravi Kiran Reddy, Lüönd, Fabiana, Meyer-Schaller, Nathalie, Christofori, Gerhard

“…Epithelial tumour cells can gain invasive and metastatic capabilities by undergoing an epithelial–mesenchymal transition. Transcriptional regulators and…”
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Déjà vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins by Petrak, Jiri, Ivanek, Robert, Toman, Ondrej, Cmejla, Radek, Cmejlova, Jana, Vyoral, Daniel, Zivny, Jan, Vulpe, Christopher D.

“…After reading many 2‐DE‐based articles featuring lists of the differentially expressed proteins, one starts experiencing a disturbing déjà vu. The same…”
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A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes by Giachino, Claudio, Boulay, Jean-Louis, Ivanek, Robert, Alvarado, Alvaro, Tostado, Cristobal, Lugert, Sebastian, Tchorz, Jan, Coban, Mustafa, Mariani, Luigi, Bettler, Bernhard, Lathia, Justin, Frank, Stephan, Pfister, Stefan, Kool, Marcel, Taylor, Verdon

“…In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an…”
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Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation by Lehmann, Frank Michael, von Burg, Nicole, Ivanek, Robert, Teufel, Claudia, Horvath, Edit, Peter, Annick, Turchinovich, Gleb, Staehli, Daniel, Eichlisberger, Tobias, Gomez de Agüero, Mercedes, Coto-Llerena, Mairene, Prchal-Murphy, Michaela, Sexl, Veronika, Bentires-Alj, Mohamed, Mueller, Christoph, Finke, Daniela

“…Although group 3 innate lymphoid cells (ILC3s) are efficient inducers of T cell responses in the spleen, they fail to induce CD4 + T cell proliferation in the…”
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SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2 by Burgener, Anne-Valérie, Bantug, Glenn R., Meyer, Benedikt J., Higgins, Rebecca, Ghosh, Adhideb, Bignucolo, Olivier, Ma, Eric H., Loeliger, Jordan, Unterstab, Gunhild, Geigges, Marco, Steiner, Rebekah, Enamorado, Michel, Ivanek, Robert, Hunziker, Danielle, Schmidt, Alexander, Müller-Durovic, Bojana, Grählert, Jasmin, Epple, Raja, Dimeloe, Sarah, Lötscher, Jonas, Sauder, Ursula, Ebnöther, Monika, Burger, Bettina, Heijnen, Ingmar, Martínez-Cano, Sarai, Cantoni, Nathan, Brücker, Rolf, Kahlert, Christian R., Sancho, David, Jones, Russell G., Navarini, Alexander, Recher, Mike, Hess, Christoph

“…Whether screening the metabolic activity of immune cells facilitates discovery of molecular pathology remains unknown. Here we prospectively screened the…”
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TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy by Kaplanová, Vilma, Sperl, Wolfgang, Houšt k, Josef, Paul, Jan, Vrbacký, Marek, Hansíková, Hana, Hejzlarová, Kate ina, Nosková, Lenka, Honzík, Tomáš, Drahota, Zden k, Zeman, Ji í, í ková, Alena, Kmoch, Stanislav, Kuss, Andreas W, Stránecký, Viktor, Mayr, Johannes A, Magner, Martin, Tesa ová, Markéta, Havlí ková, Vendula, Hartmannová, Hana, Ivánek, Robert

“…We carried out whole-genome homozygosity mapping, gene expression analysis and DNA sequencing in individuals with isolated mitochondrial ATP synthase…”
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Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia by Leonards, Katharina, Almosailleakh, Marwa, Tauchmann, Samantha, Bagger, Frederik Otzen, Thirant, Cécile, Juge, Sabine, Bock, Thomas, Méreau, Hélène, Bezerra, Matheus F., Tzankov, Alexandar, Ivanek, Robert, Losson, Régine, Peters, Antoine H. F. M., Mercher, Thomas, Schwaller, Juerg

“…The nuclear receptor binding SET domain protein 1 (NSD1) is recurrently mutated in human cancers including acute leukemia. We show that NSD1 knockdown alters…”
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The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer by Tiede, Stefanie, Meyer-Schaller, Nathalie, Kalathur, Ravi Kiran Reddy, Ivanek, Robert, Fagiani, Ernesta, Schmassmann, Philip, Stillhard, Patrick, Häfliger, Simon, Kraut, Norbert, Schweifer, Norbert, Waizenegger, Irene C., Bill, Ruben, Christofori, Gerhard

“…Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that regulates a plethora of downstream signaling pathways essential for cell migration,…”
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CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I by Falcetta, Denis, Quirim, Sandrine, Cocchiararo, Ilaria, Chabry, Florent, Théodore, Marine, Stiefvater, Adeline, Lin, Shuo, Tintignac, Lionel, Ivanek, Robert, Kinter, Jochen, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

“…Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular junctions (NMJs)…”
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Siglec Receptors Modulate Dendritic Cell Activation and Antigen Presentation to T Cells in Cancer by Wang, Jinyu, Manni, Michela, Bärenwaldt, Anne, Wieboldt, Ronja, Kirchhammer, Nicole, Ivanek, Robert, Stanczak, Michal, Zippelius, Alfred, König, David, Rodrigues Manutano, Natalia, Läubli, Heinz

“…Interactions between sialylated glycans and sialic acid-binding immunoglobulin-like lectin (Siglec) receptors have been recently described as potential new…”
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Mapping gene regulatory circuitry of Pax6 during neurogenesis by Thakurela, Sudhir, Tiwari, Neha, Schick, Sandra, Garding, Angela, Ivanek, Robert, Berninger, Benedikt, Tiwari, Vijay K

“…Pax6 is a highly conserved transcription factor among vertebrates and is important in various aspects of the central nervous system development. However, the…”
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Dominant Renin Gene Mutations Associated with Early-Onset Hyperuricemia, Anemia, and Chronic Kidney Failure by Živná, Martina, Hůlková, Helena, Matignon, Marie, Hodaňová, Kateřina, Vylet'al, Petr, Kalbáčová, Marie, Barešová, Veronika, Sikora, Jakub, Blažková, Hana, Živný, Jan, Ivánek, Robert, Stránecký, Viktor, Sovová, Jana, Claes, Kathleen, Lerut, Evelyne, Fryns, Jean-Pierre, Hart, P. Suzanne, Hart, Thomas C., Adams, Jeremy N., Pawtowski, Audrey, Clemessy, Maud, Gasc, Jean-Marie, Gübler, Marie-Claire, Antignac, Corinne, Elleder, Milan, Kapp, Katja, Grimbert, Philippe, Bleyer, Anthony J., Kmoch, Stanislav

“…Through linkage analysis and candidate gene sequencing, we identified three unrelated families with the autosomal-dominant inheritance of early onset anemia,…”
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Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD by Dertschnig, Simone, Nusspaumer, Gretel, Ivanek, Robert, Hauri-Hohl, Mathias M., Holländer, Georg A., Krenger, Werner

“…Development of acute graft-versus-host disease (aGVHD) predisposes to chronic GVHD with autoimmune manifestations. A characteristic of experimental aGVHD is…”
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