Search Results - "Ivancic, Valerie A"

Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme by Ivancic, Valerie A, Krasinski, Claire A, Zheng, Qiuchen, Meservier, Rebecca J, Spratt, Donald E, Lazo, Noel D

“…Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes and…”
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K114 (trans, trans)‐bromo‐2,5‐bis(4‐hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils by Selmani, Veli, Robbins, Kevin J., Ivancic, Valerie A., Lazo, Noel D.

“…Cationic amyloid fibrils found in human semen enhance the transmission of the human immunodeficiency virus (HIV) and thus, are named semen‐derived enhancer of…”
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Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42 by Krasinski, Claire A, Ivancic, Valerie A, Zheng, Qiuchen, Spratt, Donald E, Lazo, Noel D

“…Alzheimer’s disease (AD), the most common cause of dementia in the elderly, is the sixth leading cause of death in the United States. We hypothesize that the…”
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Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme by Zheng, Qiuchen, Kebede, Micheal T, Lee, Bethany, Krasinski, Claire A, Islam, Saadman, Wurfl, Liliana A, Kemeh, Merc M, Ivancic, Valerie A, Jakobsche, Charles E, Spratt, Donald E, Lazo, Noel D

“…The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aβ42 that has been linked to the neurodegeneration in Alzheimer's disease…”
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Advancing secondary structure characterization of monoclonal antibodies using Microfluidic Modulation Spectroscopy by Ivancic, Valerie A., Lombardo, Holly L., Ma, Eugene, Wikström, Mats, Batabyal, Dipanwita

“…Infrared (IR) spectroscopy is rapidly gaining traction for monitoring biotherapeutic critical quality attributes. Microfluidic Modulation Spectroscopy (MMS), a…”
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Binding Modes of Thioflavin T on the Surface of Amyloid Fibrils Studied by NMR by Ivancic, Valerie A., Ekanayake, Oshini, Lazo, Noel D.

“…The mechanism for the interaction of thioflavin T (ThT) with amyloid fibrils at the molecular level is not known. Here, we used 1H NMR spectroscopy to…”
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Binding Modes of ThioflavinT on the Surface of Amyloid Fibrils Studied by NMR by Ivancic, Valerie A, Ekanayake, Oshini, Lazo, Noel D

“…The mechanism for the interaction of thioflavin T (ThT) with amyloid fibrils at the molecular level is not known. Here, we used 1HNMR spectroscopy to determine…”
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The Longest Amyloid‑β Precursor Protein Intracellular Domain Produced with Aβ42 Forms β‑Sheet-Containing Monomers That Self-Assemble and Are Proteolyzed by Insulin-Degrading Enzyme by Krasinski, Claire A, Zheng, Qiuchen, Ivancic, Valerie A, Spratt, Donald E, Lazo, Noel D

“…Alzheimer’s disease (AD) is the most common neurodegenerative disease resulting in dementia. It is characterized pathologically by extracellular amyloid…”
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Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes by Zheng, Qiuchen, Lee, Bethany, Kebede, Micheal T., Ivancic, Valerie A., Kemeh, Merc M., Brito, Henrique Lemos, Spratt, Donald E., Lazo, Noel D.

“…Insulin-degrading enzyme (IDE) is an evolutionarily conserved ubiquitous zinc metalloprotease implicated in the efficient degradation of insulin monomer…”
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