Progressive multifocal leukoencephalopathy as a complication of disease-modifying treatment of multiple sclerosis

The review provides modern understanding of the pathogenesis of progressive multifocal leukoencephalopathy (PML), a severe and potentially fatal form of multiple-lesion disorder of the brain white matter. Information about the frequency of its development in patients with disease-modifying treatment...

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Bibliographic Details
Published in:	Annaly kliničeskoj i èksperimentalʹnoj nevrologii (Online) Vol. 12; no. 4; pp. 62 - 66
Main Authors:	Maria N. Zakharova, Elena V. Lysogorskaia, Maria V. Ivanova, Ivan А. Kochergin, Yulia E. Korzhova
Format:	Journal Article
Language:	English
Published:	Research Center of Neurology 01-12-2018
Subjects:	dmt multiple sclerosis natalizumab progressive multifocal leukoencephalopathy risk stratification
Online Access:	Get full text
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Summary:	The review provides modern understanding of the pathogenesis of progressive multifocal leukoencephalopathy (PML), a severe and potentially fatal form of multiple-lesion disorder of the brain white matter. Information about the frequency of its development in patients with disease-modifying treatment of multiple sclerosis is analyzed. The algorithms of optimization of PML risks in this category of patients with multiple sclerosis are described in detail. Summarized are the data on most significant PML biomarkers, the search for which is currently under way in many centers across the world. The first case of PML in Russia is briefly described.
ISSN:	2075-5473 2409-2533
DOI:	10.25692/ACEN.2018.4.9