Search Results - "Itzkovich, Chen"

RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function by Samra, Nadra, Toubiana, Shir, Yttervik, Hilde, Tzur-Gilat, Aya, Morani, Ilham, Itzkovich, Chen, Giladi, Liran, Abu Jabal, Kamal, Cao, John Z, Godley, Lucy A, Mory, Adi, Baris Feldman, Hagit, Tveten, Kristian, Selig, Sara, Weiss, Karin

“…RBL2/p130, a member of the retinoblastoma family of proteins, is a key regulator of cell division and propagates irreversible senescence. RBL2/p130 is also…”
Get full text

The retinal toxicity profile towards assemblies of Amyloid-β indicate the predominant pathophysiological activity of oligomeric species by Naaman, Efrat, Ya’ari, Sarah, Itzkovich, Chen, Safuri, Shadi, Macsi, Flora, Kellerman, Lior, Mimouni, Michael, Mann, Irit, Gazit, Ehud, Adler-Abramovich, Lihi, Zayit-Soudry, Shiri

“…Amyloid-β (Aβ), reported as a significant constituent of drusen, was implicated in the pathophysiology of age-related macular degeneration (AMD), yet the…”
Get full text

ERK Activity in Immature Leukemic Cells Drives Clonal Selection during Induction Therapy for Acute Myeloid Leukemia by Hayun, Michal, Zaatra, Maria, Itzkovich, Chen, Sahar, Dvora, Rosenberg, Dina, Filatova, Margarita, Ringelstein-Harlev, Shimrit, Baris, Hagit, Moustafa-Hawash, Nivin, Louria-Hayon, Igal, Ofran, Yishai

“…Selection of resistant clones following intensive chemotherapy is a common obstacle for cure in many cancers, particularly in acute myeloid leukemia (AML). In…”
Get full text

PEDF-derived peptide protects against Amyloid-β toxicity in vitro and prevents retinal dysfunction in rats by Qarawani, Amanda, Naaman, Efrat, Ben-Zvi Elimelech, Rony, Harel, Michal, Itzkovich, Chen, Safuri, Shadi, Dahan, Nitsan, Henkin, Jack, Zayit-Soudry, Shiri

“…Amyloid-beta (Aβ), a family of aggregation-prone and neurotoxic peptides, has been implicated in the pathophysiology of age-related macular degeneration (AMD)…”
Get full text

Plasma Soluble HLA-Bound Peptides Derived from Acute Myeloid Leukemia Patients during Induction May Predict Individual Response to Therapy by Hayun, Michal, Itzkovich, Chen, Barnea, Eilon, Admon, Arie, Louria-Hayon, Igal, Ofran, Yishai

“…Introduction: Human leukocyte antigen (HLA) molecules are membrane-bound transporters carrying peptides from the cytoplasm to the cell surface where they…”
Get full text

Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis by Aguilera-Castrejon, Alejandro, Oldak, Bernardo, Shani, Tom, Ghanem, Nadir, Itzkovich, Chen, Slomovich, Sharon, Tarazi, Shadi, Bayerl, Jonathan, Chugaeva, Valeriya, Ayyash, Muneef, Ashouokhi, Shahd, Sheban, Daoud, Livnat, Nir, Lasman, Lior, Viukov, Sergey, Zerbib, Mirie, Addadi, Yoseph, Rais, Yoach, Cheng, Saifeng, Stelzer, Yonatan, Keren-Shaul, Hadas, Shlomo, Raanan, Massarwa, Rada, Novershtern, Noa, Maza, Itay, Hanna, Jacob H.

“…The mammalian body plan is established shortly after the embryo implants into the maternal uterus, and our understanding of post-implantation developmental…”
Get full text