Search Results - "Itskovitz, Joseph"

Human Embryonic Stem Cells Exhibit Increased Propensity to Differentiate During the G1 Phase Prior to Phosphorylation of Retinoblastoma Protein by Sela, Yogev, Molotski, Natali, Golan, Saar, Itskovitz-Eldor, Joseph, Soen, Yoav

“…While experimentally induced arrest of human embryonic stem cells (hESCs) in G1 has been shown to stimulate differentiation, it remains unclear whether the…”
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Microbial‐derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells–derived and fetal hepatocytes by Avior, Yishai, Levy, Gahl, Zimerman, Michal, Kitsberg, Daniel, Schwartz, Robert, Sadeh, Ronen, Moussaieff, Arieh, Cohen, Merav, Itskovitz‐Eldor, Joseph, Nahmias, Yaakov

“…The liver is the main organ responsible for the modification, clearance, and transformational toxicity of most xenobiotics owing to its abundance in cytochrome…”
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Cardiac Fibroblast-Induced Pluripotent Stem Cell-Derived Exosomes as a Potential Therapeutic Mean for Heart Failure by Kurtzwald-Josefson, Efrat, Zeevi-Levin, Naama, Rubchevsky, Victor, Bechar Erdman, Neta, Schwartz Rohaker, Orna, Nahum, Ortal, Hochhauser, Edith, Ben-Avraham, Ben, Itskovitz-Eldor, Joseph, Aravot, Dan, Barac, Yaron D.

“…The limited regenerative capacity of the injured myocardium leads to remodeling and often heart failure. Novel therapeutic approaches are essential. Induced…”
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Functional abnormalities in iPSC‐derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations by Novak, Atara, Barad, Lili, Lorber, Avraham, Gherghiceanu, Mihaela, Reiter, Irina, Eisen, Binyamin, Eldor, Liron, Itskovitz‐Eldor, Joseph, Eldar, Michael, Arad, Michael, Binah, Ofer

“…Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia characterized by syncope and sudden death occurring during exercise or…”
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Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure by Gherghiceanu, Mihaela, Barad, Lili, Novak, Atara, Reiter, Irina, Itskovitz‐Eldor, Joseph, Binah, Ofer, Popescu, L.M.

“…Induced pluripotent stem cells (iPSC) are generated from fully differentiated somatic cells that were reprogrammed into a pluripotent state. Human iPSC which…”
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Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells by Germanguz, Igal, Sedan, Oshra, Zeevi‐Levin, Naama, Shtrichman, Ronit, Barak, Efrat, Ziskind, Anna, Eliyahu, Sivan, Meiry, Gideon, Amit, Michal, Itskovitz‐Eldor, Joseph, Binah, Ofer

“…In view of the therapeutic potential of cardiomyocytes derived from induced pluripotent stem (iPS) cells (iPS‐derived cardiomyocytes), in the present study we…”
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LIF/STAT3 Signaling Fails to Maintain Self‐Renewal of Human Embryonic Stem Cells by Dahéron, Laurence, Opitz, Sarah L., Zaehres, Holm, Lensch, William M., Andrews, Peter W., Itskovitz‐Eldor, Joseph, Daley, George Q.

“…Murine embryonic stem (mES) cells remain undifferentiated in the presence of leukemia inhibitory factor (LIF), and activation of signal transducer and…”
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Selective Ablation of Human Embryonic Stem Cells Expressing a “Suicide” Gene by Schuldiner, Maya, Itskovitz‐Eldor, Joseph, Benvenisty, Nissim

“…Over the past few years, technological procedures have been developed for utilizing stem cells in transplantation medicine. Human embryonic stem (ES) cells can…”
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Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells by Moussaieff, Arieh, Rouleau, Matthieu, Kitsberg, Daniel, Cohen, Merav, Levy, Gahl, Barasch, Dinorah, Nemirovski, Alina, Shen-Orr, Shai, Laevsky, Ilana, Amit, Michal, Bomze, David, Elena-Herrmann, Bénédicte, Scherf, Tali, Nissim-Rafinia, Malka, Kempa, Stefan, Itskovitz-Eldor, Joseph, Meshorer, Eran, Aberdam, Daniel, Nahmias, Yaakov

“…Loss of pluripotency is a gradual event whose initiating factors are largely unknown. Here we report the earliest metabolic changes induced during the first…”
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High‐Efficiency RNA Interference in Human Embryonic Stem Cells by Zaehres, Holm, Lensch, M. William, Daheron, Laurence, Stewart, Sheila A., Itskovitz‐Eldor, Joseph, Daley, George Q.

“…RNA interference methodology suppresses gene expression, thus mimicking loss‐of‐function mutation and enabling in vitro and in vivo gene function analysis. In…”
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Bioreactor cultivation enhances the efficiency of human embryoid body (hEB) formation and differentiation by Gerecht-Nir, Sharon, Cohen, Smadar, Itskovitz-Eldor, Joseph

“…The promise of human embryonic stem cells (hESCs) to provide an unlimited supply of cells for cell therapy and tissue engineering depends on the availability…”
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Therapeutic potential of perivascular cells from human pluripotent stem cells by Dar, Ayelet, Itskovitz-Eldor, Joseph

“…Vascularization of injured tissues or artificial grafts is a major challenge in tissue engineering, stimulating a continued search for alternative sources for…”
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Three-dimensional porous alginate scaffolds provide a conducive environment for generation of well-vascularized embryoid bodies from human embryonic stem cells by Gerecht-Nir, Sharon, Cohen, Smadar, Ziskind, Anna, Itskovitz-Eldor, Joseph

“…Differentiation of human embryonic stem cells (hESCs) can be instigated through the formation of embryo‐like aggregates in suspension, termed human embryoid…”
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Controlled, Scalable Embryonic Stem Cell Differentiation Culture by Dang, Stephen M., Gerecht‐Nir, Sharon, Chen, Jinny, Itskovitz‐Eldor, Joseph, Zandstra, Peter W.

“…Embryonic stem (ES) cells are of significant interest as a renewable source of therapeutically useful cells. ES cell aggregation is important for both human…”
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Functional Properties of Human Embryonic Stem Cell–Derived Cardiomyocytes: Intracellular Ca2+ Handling and the Role of Sarcoplasmic Reticulum in the Contraction by Dolnikov, Katya, Shilkrut, Mark, Zeevi‐Levin, Naama, Gerecht‐Nir, Sharon, Amit, Michal, Danon, Asaf, Itskovitz‐Eldor, Joseph, Binah, Ofer

“…Since cardiac transplantation is limited by the small availability of donor organs, regeneration of the diseased myocardium by cell transplantation is an…”
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Derivation and spontaneous differentiation of human embryonic stem cells by Amit, Michal, Itskovitz‐Eldor, Joseph

“…Embryonic stem (ES) cells are unique cells derived from the inner cell mass of the mammalian blastocyst. These cells are immortal and pluripotent, retain their…”
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From beat rate variability in induced pluripotent stem cell–derived pacemaker cells to heart rate variability in human subjects by Ben-Ari, Meital, BSc, Schick, Revital, BSc, Barad, Lili, BSc, Novak, Atara, MSc, Ben-Ari, Erez, BSc, Lorber, Avraham, MD, Itskovitz-Eldor, Joseph, MD, PhD, Rosen, Michael R., MD, FHRS, Weissman, Amir, MD, Binah, Ofer, PhD

“…Background We previously reported that induced pluripotent stem cell–derived cardiomyocytes manifest beat rate variability (BRV) resembling heart rate…”
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Differentiation In Vivo of Cardiac Committed Human Embryonic Stem Cells in Postmyocardial Infarcted Rats by Tomescot, André, Leschik, Julia, Bellamy, Valérie, Dubois, Gilbert, Messas, Emmanuel, Bruneval, Patrick, Desnos, Michel, Hagège, Albert A., Amit, Michal, Itskovitz, Joseph, Menasché, Philippe, Pucéat, Michel

“…Human embryonic stem (HES) cells can give rise to cardiomyocytes in vitro. However, whether undifferentiated HES cells also feature a myocardial regenerative…”
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20th Anniversary of Isolation of Human Embryonic Stem Cells: A Personal Perspective by Itskovitz-Eldor, Joseph

“…Following Jamie Thomson's lecture on primate embryonic stem cells (ESCs) at a meeting I had organized in March 1997, in Israel, to celebrate receipt of the…”
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Multipotent Vasculogenic Pericytes From Human Pluripotent Stem Cells Promote Recovery of Murine Ischemic Limb by DAR, Ayelet, DOMEV, Hagit, BEN-YOSEF, Oren, TZUKERMAN, Maty, ZEEVI-LEVIN, Naama, NOVAK, Atara, GERMANGUZ, Igal, AMIT, Michal, ITSKOVITZ-ELDOR, Joseph

“…Pericytes represent a unique subtype of microvessel-residing perivascular cells with diverse angiogenic functions and multilineage developmental features of…”
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