Search Results - "Itoyama, Rumi"

Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance by Uchihara, Tomoyuki, Miyake, Keisuke, Yonemura, Atsuko, Komohara, Yoshihiro, Itoyama, Rumi, Koiwa, Mayu, Yasuda, Tadahito, Arima, Kota, Harada, Kazuto, Eto, Kojiro, Hayashi, Hiromitsu, Iwatsuki, Masaaki, Iwagami, Shiro, Baba, Yoshifumi, Yoshida, Naoya, Yashiro, Masakazu, Masuda, Mari, Ajani, Jaffer A, Tan, Patrick, Baba, Hideo, Ishimoto, Takatsugu

“…Extracellular vesicles (EV) from cancer-associated fibroblasts (CAF) are composed of diverse payloads. Although CAFs impact the aggressive characteristics of…”
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Clinical Significance of PD-L1 Expression in Both Cancer and Stroma Cells of Cholangiocarcinoma Patients by Kitano, Yuki, Yamashita, Yo-ichi, Nakao, Yosuke, Itoyama, Rumi, Yusa, Toshihiko, Umezaki, Naoki, Tsukamoto, Masayo, Yamao, Takanobu, Miyata, Tatsunori, Nakagawa, Shigeki, Okabe, Hirohisa, Imai, Katsunori, Chikamoto, Akira, Ishiko, Takatoshi, Baba, Hideo

“…Background The clinical significance of programmed death 1 and its ligand (PD-L1) as therapeutic targets has been reported previously. This study aimed to…”
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Survival impact of immune cells infiltrating peritumoral area of hepatocellular carcinoma by Yusa, Toshihiko, Yamashita, Yo‐ichi, Okabe, Hirohisa, Nakao, Yosuke, Itoyama, Rumi, Kitano, Yuki, Kaida, Takayoshi, Miyata, Tatsunori, Mima, Kosuke, Imai, Katsunori, Hayashi, Hiromitsu, Baba, Hideo

“…Inflammatory and immune cells in the tumor microenvironment are reported to be associated with tumor progression in several cancers. In total, 225 patients who…”
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Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination by Yasuda, Tadahito, Koiwa, Mayu, Yonemura, Atsuko, Miyake, Keisuke, Kariya, Ryusho, Kubota, Sho, Yokomizo-Nakano, Takako, Yasuda-Yoshihara, Noriko, Uchihara, Tomoyuki, Itoyama, Rumi, Bu, Luke, Fu, Lingfeng, Arima, Kota, Izumi, Daisuke, Iwagami, Shiro, Eto, Kojiro, Iwatsuki, Masaaki, Baba, Yoshifumi, Yoshida, Naoya, Ohguchi, Hiroto, Okada, Seiji, Matsusaki, Keisuke, Sashida, Goro, Takahashi, Akiko, Tan, Patrick, Baba, Hideo, Ishimoto, Takatsugu

“…In the tumor microenvironment, senescent non-malignant cells, including cancer-associated fibroblasts (CAFs), exhibit a secretory profile under stress…”
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IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment by Zhang, Jun, Fu, Lingfeng, Yasuda-Yoshihara, Noriko, Yonemura, Atsuko, Wei, Feng, Bu, Luke, Hu, Xichen, Akiyama, Takahiko, Kitamura, Fumimasa, Yasuda, Tadahito, Semba, Takashi, Uchihara, Tomoyuki, Itoyama, Rumi, Yamashita, Kohei, Eto, Kojiro, Iwagami, Shiro, Yashiro, Masakazu, Komohara, Yoshihiro, Baba, Hideo, Ishimoto, Takatsugu

“…Background Remodeling the tumor microenvironment (TME) to benefit cancer cells is crucial for tumor progression. Although diffuse-type gastric cancer (DGC)…”
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Frailty is associated with poor prognosis after resection for pancreatic cancer by Mima, Kosuke, Hayashi, Hiromitsu, Nakagawa, Shigeki, Matsumoto, Takashi, Kinoshita, Shotaro, Matsumura, Kazuki, Kitamura, Fumimasa, Uemura, Norio, Nakao, Yosuke, Itoyama, Rumi, Kaida, Takayoshi, Imai, Katsunori, Yamashita, Yo-ichi, Baba, Hideo

“…Background With population aging, the number of frail patients with pancreatic cancer has increased. The Clinical Frailty Scale (CFS) is a simple and validated…”
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Prognostic Value of the Preoperative Tumor Marker Index in Resected Pancreatic Ductal Adenocarcinoma: A Retrospective Single-Institution Study by Miyata, Tatsunori, Hayashi, Hiromitsu, Yamashita, Yo-ichi, Matsumura, Kazuki, Nakao, Yosuke, Itoyama, Rumi, Yamao, Takanobu, Tsukamoto, Masayo, Okabe, Hirohisa, Imai, Katsunori, Chikamoto, Akira, Ishiko, Takatoshi, Baba, Hideo

“…Background The prediction of prognostic outcomes can provide the most suitable strategy for patients with pancreatic ductal adenocarcinoma (PDAC). This study…”
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Tumor microenvironmental 15‐PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer by Bu, Luke, Yonemura, Atsuko, Yasuda‐Yoshihara, Noriko, Uchihara, Tomoyuki, Ismagulov, Galym, Takasugi, Sanae, Yasuda, Tadahito, Okamoto, Yuya, Kitamura, Fumimasa, Akiyama, Takahiko, Arima, Kota, Itoyama, Rumi, Zhang, Jun, Fu, Lingfeng, Hu, Xichen, Wei, Feng, Arima, Yuichiro, Moroishi, Toshiro, Nishiyama, Koichi, Sheng, Guojun, Mukunoki, Toshifumi, Otani, Jun, Baba, Hideo, Ishimoto, Takatsugu

“…The arachidonic acid cascade is a major inflammatory pathway that produces prostaglandin E2 (PGE2). Although inhibition of 15‐hydroxyprostaglandin…”
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Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer by Itoyama, Rumi, Yasuda-Yoshihara, Noriko, Kitamura, Fumimasa, Yasuda, Tadahito, Bu, Luke, Yonemura, Atsuko, Uchihara, Tomoyuki, Arima, Kota, Hu, Xichen, Jun, Zhang, Okamoto, Yuya, Akiyama, Takahiko, Yamashita, Kohei, Nakao, Yosuke, Yusa, Toshihiko, Kitano, Yuki, Higashi, Takaaki, Miyata, Tatsunori, Imai, Katsunori, Hayashi, Hiromitsu, Yamashita, Yo-ichi, Mikawa, Takumi, Kondoh, Hiroshi, Baba, Hideo, Ishimoto, Takatsugu

“…Cancer cells craftily adapt their energy metabolism to their microenvironment. Nutrient deprivation due to hypovascularity and fibrosis is a major…”
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MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma by El-mezayen, Hatem, Yamamura, Kensuke, Yusa, Toshihiko, Nakao, Yosuke, Uemura, Norio, Kitamura, Fumimasa, Itoyama, Rumi, Yamao, Takanobu, Higashi, Takaaki, Hayashi, Hiromitsu, Imai, Katsunori, Chikamoto, Akira, Yamashita, Yo-ichi, Baba, Hideo

“…Background MicroRNA (miRNA) expression abnormalities are implicated in tumor progression. Previous reports have indicated that microRNA-25 (miR-25) acts as a…”
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High ARHGEF2 (GEF-H1) Expression is Associated with Poor Prognosis Via Cell Cycle Regulation in Patients with Pancreatic Cancer by Nakao, Yosuke, Nakagawa, Shigeki, Yamashita, Yo-ichi, Umezaki, Naoki, Okamoto, Yuya, Ogata, Yoko, Yasuda-Yoshihara, Noriko, Itoyama, Rumi, Yusa, Toshihiko, Yamashita, Kohei, Miyata, Tatsunori, Okabe, Hirohisa, Hayashi, Hiromitsu, Imai, Katsunori, Baba, Hideo

“…Background Pancreatic cancer has an extremely poor prognosis, even after curative resection. Treatment options for pancreatic cancer remain limited, therefore…”
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Downregulation of 15‐hydroxyprostaglandin dehydrogenase by interleukin‐1β from activated macrophages leads to poor prognosis in pancreatic cancer by Arima, Kota, Komohara, Yoshihiro, Bu, Luke, Tsukamoto, Masayo, Itoyama, Rumi, Miyake, Keisuke, Uchihara, Tomoyuki, Ogata, Yoko, Nakagawa, Shigeki, Okabe, Hirohisa, Imai, Katsunori, Hashimoto, Daisuke, Chikamoto, Akira, Yamashita, Yo‐ichi, Baba, Hideo, Ishimoto, Takatsugu

“…Chronic inflammation has a crucial role in cancer development and the progression of various tumors, including pancreatic ductal adenocarcinoma (PDAC). The…”
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Intraoperative bile culture helps choosing antibiotics in pancreaticoduodenectomy: Mechanistic profiling study of complex rink between bacterobilia and postoperative complications by Itoyama, Rumi, Okabe, Hirohisa, Yamashita, Yo‐ichi, Kitamura, Fumimasa, Uemura, Norio, Nakao, Yosuke, Yusa, Toshihiko, Imai, Katsunori, Hayashi, Hiromitsu, Baba, Hideo

“…Background Postoperative complications after pancreaticoduodenectomy (PD) is still a major concern. The aim of this study was to propose how to choose…”
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Efficacy of Ring Drape and Unused Sterile Instruments for Incisional SSI After Hepatectomy by Yusa, Toshihiko, Yamashita, Yo-Ichi, Nitta, Hidetoshi, Nakao, Yosuke, Itoyama, Rumi, Kitano, Yuki, Kaida, Takayoshi, Miyata, Tatsunori, Mima, Kosuke, Imai, Katsunori, Hayashi, Hiromitsu, Baba, Hideo

“…The aim of this study was to verify the efficacy of wound protection with a plastic ring wound protector (ring drape) and using new sterile instruments when…”
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The pivotal predictor of severe postoperative complications of pancreatoduodenectomy: complex links of bacterial contamination from preoperative biliary drainage by Itoyama, Rumi, Okabe, Hirohisa, Nakao, Yosuke, Yusa, Toshihiko, Nakagawa, Shigeki, Imai, Katsunori, Hayashi, Hiromitsu, Yamashita, Yo-ichi, Baba, Hideo

“…Purpose Preoperative biliary drainage (PBD) prior to pancreatoduodenectomy (PD) is controversial. The aim of this study was to clarify how PBD leads to…”
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Interval laparoscopic appendectomy after antibiotic therapy for appendiceal abscess in elderly patients by Mima, Kosuke, Miyanari, Nobutomo, Itoyama, Rumi, Nakao, Yosuke, Kato, Rikako, Shigaki, Hironobu, Kurashige, Junji, Inoue, Mitsuhiro, Iwagami, Shiro, Mizumoto, Takao, Kubota, Tatsuo, Baba, Hideo

“…Introduction The aim of this study was to evaluate the safety and efficacy of interval laparoscopic appendectomy after antibiotic therapy in elderly patients…”
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Postoperative nonalcoholic fatty liver disease is correlated with malnutrition leading to an unpreferable clinical course for pancreatic cancer patients undergoing pancreaticoduodenectomy by Okabe, Hirohisa, Yamashita, Yo-ichi, Inoue, Risa, Kinoshita, Shotaro, Itoyama, Rumi, Yusa, Toshihiko, Nakao, Yosuke, Yamao, Takanobu, Umezaki, Naoki, Tsukamoto, Masayo, Kitano, Yuki, Miyata, Tatsunori, Arima, Kota, Hayashi, Hiromitsu, Imai, Katsunori, Chikamoto, Akira, Baba, Hideo

“…Purposes This study aimed to clarify the impact of postoperative nonalcoholic fatty liver disease (NAFLD) on the clinical course of patients with pancreatic…”
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Clinical role of fludeoxyglucose (18F) positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with pancreatic neuroendocrine tumors by Matsumoto, Takashi, Okabe, Hirohisa, Yamashita, Yo-ichi, Yusa, Toshihiko, Itoyama, Rumi, Nakao, Yosuke, Yamao, Takanobu, Umzaki, Naoki, Tsukamoto, Masayo, Kitano, Yuki, Miyata, Tatsunori, Arima, Kota, Nitta, Hidetoshi, Hayashi, Hiromitsu, Imai, Katsunori, Chikamoto, Akira, Baba, Hideo

“…Purposes Clinical predictive markers for the malignant potential of pancreatic neuroendocrine tumors (PNETs) are limited without histological investigation. We…”
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Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer by Kitamura, Fumimasa, Semba, Takashi, Yasuda-Yoshihara, Noriko, Yamada, Kosuke, Nishimura, Akiho, Yamasaki, Juntaro, Nagano, Osamu, Yasuda, Tadahito, Yonemura, Atsuko, Tong, Yilin, Wang, Huaitao, Akiyama, Takahiko, Matsumura, Kazuki, Uemura, Norio, Itoyama, Rumi, Bu, Luke, Fu, Lingfeng, Hu, Xichen, Wei, Feng, Mima, Kosuke, Imai, Katsunori, Hayashi, Hiromitsu, Yamashita, Yo-Ichi, Miyamoto, Yuji, Baba, Hideo, Ishimoto, Takatsugu

“…Glycolysis is highly enhanced in pancreatic ductal adenocarcinoma (PDAC) cells; thus, glucose restrictions are imposed on nontumor cells in the PDAC tumor…”
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Clinical role of serum programmed death ligand 1 in patients with hepatocellular carcinoma: Where does it come from? by Elmezayen, Hatem A., Okabe, Hirohisa, Baba, Yoshifumi, Yusa, Toshihiko, Itoyama, Rumi, Nakao, Yosuke, Yamao, Takanobu, Umzaki, Naoki, Tsukamoto, Masayo, Kitano, Yuki, Miyata, Tatsunori, Arima, Kota, Hayashi, Hiromitsu, Imai, Katsunori, Chikamoto, Akira, Yamashita, Yo-ichi, Baba, Hideo

“…Purposes Programmed death ligand 1 (PD-L1) is a key target for the treatment of several malignancies. The present study was conducted to clarify the role of…”
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