Search Results - "Ito, Takumi"

Molecular mechanisms of thalidomide and its derivatives by ITO, Takumi, HANDA, Hiroshi

“…Thalidomide, originally developed as a sedative drug, causes multiple defects due to severe teratogenicity, but it has been re-purposed for treating multiple…”
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Protein degraders - from thalidomide to new PROTACs by Ito, Takumi

“…Abstract Recently, the development of protein degraders (protein-degrading compounds) has prominently progressed. There are two remarkable classes of protein…”
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Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs by Ito, Takumi, Handa, Hiroshi

“…Thalidomide was first developed as a sedative around 60 years ago, but exhibited teratogenicity, leading to serious defects such as limb deformities…”
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Molecular Mechanisms of the Teratogenic Effects of Thalidomide by Asatsuma-Okumura, Tomoko, Ito, Takumi, Handa, Hiroshi

“…Thalidomide was sold worldwide as a sedative over 60 years ago, but it was quickly withdrawn from the market due to its teratogenic effects. Thalidomide was…”
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Quantitative estimation method for urban areas to develop compact cities in view of unprecedented population decline by Miyauchi, Takashi, Setoguchi, Tsuyoshi, Ito, Takumi

“…In Japan, high economic growth after the war brought about disorderly urban sprawl. The government then enforced an “area division system,” which divided city…”
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Acceleration of sludge drying using resin emulsions and estimation of drying acceleration mechanism by Kobayashi, Nobusuke, Ito, Takumi, Ooki, Hironari, Itaya, Yoshinori

“…Sludge accounts for the highest percentage of waste emissions and needs to be treated efficiently for environmental issues, such as water problems, sanitation…”
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p63 is a cereblon substrate involved in thalidomide teratogenicity by Asatsuma-Okumura, Tomoko, Ando, Hideki, De Simone, Marco, Yamamoto, Junichi, Sato, Tomomi, Shimizu, Nobuyuki, Asakawa, Kazuhide, Yamaguchi, Yuki, Ito, Takumi, Guerrini, Luisa, Handa, Hiroshi

“…Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple pharmacological activities, including teratogenic and antimyeloma activities. CRBN…”
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Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs by Chamberlain, Philip P, Lopez-Girona, Antonia, Miller, Karen, Carmel, Gilles, Pagarigan, Barbra, Chie-Leon, Barbara, Rychak, Emily, Corral, Laura G, Ren, Yan J, Wang, Maria, Riley, Mariko, Delker, Silvia L, Ito, Takumi, Ando, Hideki, Mori, Tomoyuki, Hirano, Yoshinori, Handa, Hiroshi, Hakoshima, Toshio, Daniel, Thomas O, Cathers, Brian E

“…The protein Cereblon, part of an ubiquitin E3 ligase complex, is the target for anticancer thalidomide analogs. The crystal structure of human Cereblon-DDB1…”
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Identification of a Primary Target of Thalidomide Teratogenicity by Ito, Takumi, Ando, Hideki, Suzuki, Takayuki, Ogura, Toshihiko, Hotta, Kentaro, Imamura, Yoshimasa, Yamaguchi, Yuki, Handa, Hiroshi

“…Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today,…”
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ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells by Yamamoto, Junichi, Suwa, Tetsufumi, Murase, Yuki, Tateno, Shumpei, Mizutome, Hirotaka, Asatsuma-Okumura, Tomoko, Shimizu, Nobuyuki, Kishi, Tsutomu, Momose, Shuji, Kizaki, Masahiro, Ito, Takumi, Yamaguchi, Yuki, Handa, Hiroshi

“…The immunomodulatory drug (IMiD) thalidomide and its derivatives lenalidomide and pomalidomide are therapeutic agents used in the treatment of multiple…”
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Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide by Tateno, Shumpei, Iida, Midori, Fujii, Satoshi, Suwa, Tetsufumi, Katayama, Miki, Tokuyama, Haruka, Yamamoto, Junichi, Ito, Takumi, Sakamoto, Satoshi, Handa, Hiroshi, Yamaguchi, Yuki

“…Pomalidomide, a derivative of thalidomide, is an effective treatment for multiple myeloma. The drug exerts its effects through CRBN, a component of the E3…”
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Zebrafish Danio rerio myotomal muscle structure and growth from a spatial transcriptomics perspective by Liu, Guanting, Ito, Takumi, Kijima, Yusuke, Yoshitake, Kazutoshi, Asakawa, Shuichi, Watabe, Shugo, Kinoshita, Shigeharu

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Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats by Marunouchi, Tetsuro, Ito, Takumi, Onda, Sumika, Kyo, Lina, Takahashi, Kirara, Uchida, Manami, Yano, Emi, Tanonaka, Kouichi

“…In a previous study, we suggested that the Hsp90 inhibitor 17-AAG prevents cardiac dysfunction in the failing heart following myocardial infarction in rats…”
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Royal Jelly Enhances the Ability of Myoblast C2C12 Cells to Differentiate into Multilineage Cells by Ito, Takumi, Rojasawasthien, Thira, Takeuchi, Sachiko Yamashita, Okamoto, Hideto, Okumura, Nobuaki, Shirakawa, Tomohiko, Matsubara, Takuma, Kawamoto, Tatsuo, Kokabu, Shoichiro

“…Royal jelly (RJ) is recognized as beneficial to mammalian health. Multilineage differentiation potential is an important property of mesenchymal stem cells…”
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Teratogenic effects of thalidomide: molecular mechanisms by Ito, Takumi, Ando, Hideki, Handa, Hiroshi

“…Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of multiple birth defects. The drug is now used in the treatment of…”
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Development of Endoskeleton Type Knee Joint Assist Orthosis Using McKibben Type Artificial Muscle by Uchiyama, Kiichi, Ito, Takumi, Tomori, Hiroki

“…The Japanese agriculture industry, faced with the problem of declining and aging farmers, has keenly called for the development of body assist orthoses for…”
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Four single-spin Rabi oscillations in a quadruple quantum dot by Ito, Takumi, Otsuka, Tomohiro, Nakajima, Takashi, Delbecq, Matthieu R., Amaha, Shinichi, Yoneda, Jun, Takeda, Kenta, Noiri, Akito, Allison, Giles, Ludwig, Arne, Wieck, Andreas D., Tarucha, Seigo

“…Scaling up qubits is a necessary step to realize useful systems of quantum computation. Here, we demonstrate coherent manipulations of four individual electron…”
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Structural basis of thalidomide enantiomer binding to cereblon by Mori, Tomoyuki, Ito, Takumi, Liu, Shujie, Ando, Hideki, Sakamoto, Satoshi, Yamaguchi, Yuki, Tokunaga, Etsuko, Shibata, Norio, Handa, Hiroshi, Hakoshima, Toshio

“…Thalidomide possesses two optical isomers which have been reported to exhibit different pharmacological and toxicological activities. However, the precise…”
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Optically driven microtools with an antibody‐immobilised surface for on‐site cell assembly by Mori, Shuntaro, Ito, Takumi, Takao, Hidekuni, Shimokawa, Fusao, Terao, Kyohei

“…To enable the accurate reproduction of organs in vitro, and improve drug screening efficiency and regenerative medicine research, it is necessary to assemble…”
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Detection and control of charge states in a quintuple quantum dot by Ito, Takumi, Otsuka, Tomohiro, Amaha, Shinichi, Delbecq, Matthieu R., Nakajima, Takashi, Yoneda, Jun, Takeda, Kenta, Allison, Giles, Noiri, Akito, Kawasaki, Kento, Tarucha, Seigo

“…A semiconductor quintuple quantum dot with two charge sensors and an additional contact to the center dot from an electron reservoir is fabricated to…”
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