Search Results - "Ito, Mutsumi"

Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB by Imai, Masaki, Ito, Mutsumi, Kiso, Maki, Yamayoshi, Seiya, Uraki, Ryuta, Fukushi, Shuetsu, Watanabe, Shinji, Suzuki, Tadaki, Maeda, Ken, Sakai-Tagawa, Yuko, Iwatsuki-Horimoto, Kiyoko, Halfmann, Peter J., Kawaoka, Yoshihiro

“…Neither bebtelovimab nor any mAb combinations tested neutralized the SARS-CoV-2 omicron subvariants BQ.1.1 and XBB, but remdesivir, molnupiravir, and…”
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Efficacy of Antibodies and Antiviral Drugs against Omicron BA.2.12.1, BA.4, and BA.5 Subvariants by Takashita, Emi, Yamayoshi, Seiya, Simon, Viviana, van Bakel, Harm, Sordillo, Emilia M., Pekosz, Andrew, Fukushi, Shuetsu, Suzuki, Tadaki, Maeda, Ken, Halfmann, Peter, Sakai-Tagawa, Yuko, Ito, Mutsumi, Watanabe, Shinji, Imai, Masaki, Hasegawa, Hideki, Kawaoka, Yoshihiro

“…In this study, investigators who were evaluating in vitro neutralization of omicron subvariants by monoclonal antibodies and antiviral drugs found considerable…”
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Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2 by Takashita, Emi, Kinoshita, Noriko, Yamayoshi, Seiya, Sakai-Tagawa, Yuko, Fujisaki, Seiichiro, Ito, Mutsumi, Iwatsuki-Horimoto, Kiyoko, Halfmann, Peter, Watanabe, Shinji, Maeda, Kenji, Imai, Masaki, Mitsuya, Hiroaki, Ohmagari, Norio, Takeda, Makoto, Hasegawa, Hideki, Kawaoka, Yoshihiro

“…The in vitro activity of monoclonal antibodies and antiviral agents was assessed against the sublineages of the SARS-CoV-2 variant of concern omicron (BA.1,…”
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Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant by Takashita, Emi, Kinoshita, Noriko, Yamayoshi, Seiya, Sakai-Tagawa, Yuko, Fujisaki, Seiichiro, Ito, Mutsumi, Iwatsuki-Horimoto, Kiyoko, Chiba, Shiho, Halfmann, Peter, Nagai, Hiroyuki, Saito, Makoto, Adachi, Eisuke, Sullivan, David, Pekosz, Andrew, Watanabe, Shinji, Maeda, Kenji, Imai, Masaki, Yotsuyanagi, Hiroshi, Mitsuya, Hiroaki, Ohmagari, Norio, Takeda, Makoto, Hasegawa, Hideki, Kawaoka, Yoshihiro

“…Investigators assessed the in vitro activities of seven monoclonal antibodies and three antiviral drugs against Covid-19 variants of concern. All the…”
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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development by Imai, Masaki, Iwatsuki-Horimoto, Kiyoko, Hatta, Masato, Loeber, Samantha, Halfmann, Peter J., Nakajima, Noriko, Watanabe, Tokiko, Ujie, Michiko, Takahashi, Kenta, Ito, Mutsumi, Yamada, Shinya, Fan, Shufang, Chiba, Shiho, Kuroda, Makoto, Guan, Lizheng, Takada, Kosuke, Armbrust, Tammy, Balogh, Aaron, Furusawa, Yuri, Okuda, Moe, Ueki, Hiroshi, Yasuhara, Atsuhiro, Sakai-Tagawa, Yuko, Lopes, Tiago J. S., Kiso, Maki, Yamayoshi, Seiya, Kinoshita, Noriko, Ohmagari, Norio, Hattori, Shin-ichiro, Takeda, Makoto, Mitsuya, Hiroaki, Krammer, Florian, Suzuki, Tadaki, Kawaoka, Yoshihiro

“…At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around…”
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Characterization of SARS-CoV-2 Omicron BA.4 and BA.5 isolates in rodents by Uraki, Ryuta, Halfmann, Peter J., Iida, Shun, Yamayoshi, Seiya, Furusawa, Yuri, Kiso, Maki, Ito, Mutsumi, Iwatsuki-Horimoto, Kiyoko, Mine, Sohtaro, Kuroda, Makoto, Maemura, Tadashi, Sakai-Tagawa, Yuko, Ueki, Hiroshi, Li, Rong, Liu, Yanan, Larson, Deanna, Fukushi, Shuetsu, Watanabe, Shinji, Maeda, Ken, Pekosz, Andrew, Kandeil, Ahmed, Webby, Richard J., Wang, Zhongde, Imai, Masaki, Suzuki, Tadaki, Kawaoka, Yoshihiro

“…The BA.2 sublineage of the SARS-CoV-2 Omicron variant has become dominant in most countries around the world; however, the prevalence of BA.4 and BA.5 is…”
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Favorite Parts of a Single Leaf for Giant Flying Squirrels to Eat in Three Species of Food Trees by Ito, Mutsumi, Tamura, Noriko, Hayashi, Fumio

“…To examine the effect of leaf chemical composition on selective herbivory by the Japanese giant flying squirrels (Petaurista leucogenys), we measured and…”
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Efficacy of Antiviral Agents against the Omicron Subvariant BA.2.75 by Takashita, Emi, Yamayoshi, Seiya, Fukushi, Shuetsu, Suzuki, Tadaki, Maeda, Ken, Sakai-Tagawa, Yuko, Ito, Mutsumi, Uraki, Ryuta, Halfmann, Peter, Watanabe, Shinji, Takeda, Makoto, Hasegawa, Hideki, Imai, Masaki, Kawaoka, Yoshihiro

“…In vitro assessment of the susceptibility of BA.2.75 to approved antibodies and antivirals showed neutralizing efficacy by bebtelovimab and…”
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Comparison of Rapid Antigen Tests for COVID-19 by Yamayoshi, Seiya, Sakai-Tagawa, Yuko, Koga, Michiko, Akasaka, Osamu, Nakachi, Ichiro, Koh, Hidefumi, Maeda, Kenji, Adachi, Eisuke, Saito, Makoto, Nagai, Hiroyuki, Ikeuchi, Kazuhiko, Ogura, Takayuki, Baba, Rie, Fujita, Kensuke, Fukui, Takahiro, Ito, Fumimaro, Hattori, Shin-Ichiro, Yamamoto, Kei, Nakamoto, Takato, Furusawa, Yuri, Yasuhara, Atsuhiro, Ujie, Michiko, Yamada, Shinya, Ito, Mutsumi, Mitsuya, Hiroaki, Omagari, Norio, Yotsuyanagi, Hiroshi, Iwatsuki-Horimoto, Kiyoko, Imai, Masaki, Kawaoka, Yoshihiro

“…Reverse transcription-quantitative PCR (RT-qPCR)-based tests are widely used to diagnose coronavirus disease 2019 (COVID-19). As a result that these tests…”
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Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans by Yamayoshi, Seiya, Kiso, Maki, Yasuhara, Atsuhiro, Ito, Mutsumi, Shu, Yuelong, Kawaoka, Yoshihiro

“…To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex…”
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Highly Neutralizing COVID-19 Convalescent Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters by Takamatsu, Yuki, Imai, Masaki, Maeda, Kenji, Nakajima, Noriko, Higashi-Kuwata, Nobuyo, Iwatsuki-Horimoto, Kiyoko, Ito, Mutsumi, Kiso, Maki, Maemura, Tadashi, Takeda, Yuichiro, Omata, Kazumi, Suzuki, Tadaki, Kawaoka, Yoshihiro, Mitsuya, Hiroaki

“…Despite various attempts to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with COVID-19 convalescent plasmas, neither…”
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A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets by Imai, Masaki, Watanabe, Tokiko, Kiso, Maki, Nakajima, Noriko, Yamayoshi, Seiya, Iwatsuki-Horimoto, Kiyoko, Hatta, Masato, Yamada, Shinya, Ito, Mutsumi, Sakai-Tagawa, Yuko, Shirakura, Masayuki, Takashita, Emi, Fujisaki, Seiichiro, McBride, Ryan, Thompson, Andrew J., Takahashi, Kenta, Maemura, Tadashi, Mitake, Hiromichi, Chiba, Shiho, Zhong, Gongxun, Fan, Shufang, Oishi, Kohei, Yasuhara, Atsuhiro, Takada, Kosuke, Nakao, Tomomi, Fukuyama, Satoshi, Yamashita, Makoto, Lopes, Tiago J.S., Neumann, Gabriele, Odagiri, Takato, Watanabe, Shinji, Shu, Yuelong, Paulson, James C., Hasegawa, Hideki, Kawaoka, Yoshihiro

“…Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire…”
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Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene by Wu, Nicholas C., Yamayoshi, Seiya, Ito, Mutsumi, Uraki, Ryuta, Kawaoka, Yoshihiro, Wilson, Ian A.

“…Discovery and characterization of broadly neutralizing antibodies (bnAbs) to the influenza hemagglutinin (HA) stem have provided insights for the development…”
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Efficacy of antivirals and bivalent mRNA vaccines against SARS-CoV-2 isolate CH.1.1 by Uraki, Ryuta, Ito, Mutsumi, Kiso, Maki, Yamayoshi, Seiya, Iwatsuki-Horimoto, Kiyoko, Sakai-Tagawa, Yuko, Furusawa, Yuri, Imai, Masaki, Koga, Michiko, Yamamoto, Shinya, Adachi, Eisuke, Saito, Makoto, Tsutsumi, Takeya, Otani, Amato, Kashima, Yukie, Kikuchi, Tetsuhiro, Yotsuyanagi, Hiroshi, Suzuki, Yutaka, Kawaoka, Yoshihiro

“…[...]we assessed the efficacy of therapeutic monoclonal antibodies against a clinical isolate of omicron CH.1.1 (the sequence is registered with the Global…”
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In Vitro Efficacy of Antiviral Agents against Omicron Subvariant BA.4.6 by Takashita, Emi, Yamayoshi, Seiya, Halfmann, Peter, Wilson, Nancy, Ries, Hunter, Richardson, Alex, Bobholz, Max, Vuyk, William, Maddox, Robert, Baker, David A., Friedrich, Thomas C., O’Connor, David H., Uraki, Ryuta, Ito, Mutsumi, Sakai-Tagawa, Yuko, Adachi, Eisuke, Saito, Makoto, Koga, Michiko, Tsutsumi, Takeya, Iwatsuki-Horimoto, Kiyoko, Kiso, Maki, Yotsuyanagi, Hiroshi, Watanabe, Shinji, Hasegawa, Hideki, Imai, Masaki, Kawaoka, Yoshihiro

“…Researchers report that antiviral agents remdesivir, molnupiravir, and nirmatrelvir and monoclonal antibodies bebtelovimab and imdevimab retain effectiveness…”
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Antibody titers against SARS-CoV-2 decline, but do not disappear for several months by Yamayoshi, Seiya, Yasuhara, Atsuhiro, Ito, Mutsumi, Akasaka, Osamu, Nakamura, Morio, Nakachi, Ichiro, Koga, Michiko, Mitamura, Keiko, Yagi, Kazuma, Maeda, Kenji, Kato, Hideaki, Nojima, Masanori, Pattinson, David, Ogura, Takayuki, Baba, Rie, Fujita, Kensuke, Nagai, Hiroyuki, Yamamoto, Shinya, Saito, Makoto, Adachi, Eisuke, Ochi, Junichi, Hattori, Shin-ichiro, Suzuki, Tetsuya, Miyazato, Yusuke, Chiba, Shiho, Okuda, Moe, Murakami, Jurika, Hamabata, Taiki, Iwatsuki-Horimoto, Kiyoko, Nakajima, Hideaki, Mitsuya, Hiroaki, Omagari, Norio, Sugaya, Norio, Yotsuyanagi, Hiroshi, Kawaoka, Yoshihiro

“…To develop an effective vaccine against a novel viral pathogen, it is important to understand the longitudinal antibody responses against its first infection…”
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A 265-Nanometer High-Power Deep-UV Light-Emitting Diode Rapidly Inactivates SARS-CoV-2 Aerosols by Ueki, Hiroshi, Ito, Mutsumi, Furusawa, Yuri, Yamayoshi, Seiya, Inoue, Shin-Ichiro, Kawaoka, Yoshihiro

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) is an acute respiratory infection transmitted by droplets, aerosols, and…”
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Long-term culture of human lung adenocarcinoma A549 cells enhances the replication of human influenza A viruses by Ujie, Michiko, Takada, Kosuke, Kiso, Maki, Sakai-Tagawa, Yuko, Ito, Mutsumi, Nakamura, Kazuya, Watanabe, Shinji, Imai, Masaki, Kawaoka, Yoshihiro

“…Long-term culture of the human lung adenocarcinoma cell line A549 promotes the differentiation of these cells toward an alveolar type II cell phenotype. Here,…”
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Characterization of a SARS-CoV-2 EG.5.1 clinical isolate in vitro and in vivo by Uraki, Ryuta, Kiso, Maki, Iwatsuki-Horimoto, Kiyoko, Yamayoshi, Seiya, Ito, Mutsumi, Chiba, Shiho, Sakai-Tagawa, Yuko, Imai, Masaki, Kashima, Yukie, Koga, Michiko, Fuwa, Noriko, Okumura, Nobumasa, Hojo, Masayuki, Iwamoto, Noriko, Kato, Hideaki, Nakajima, Hideaki, Ohmagari, Norio, Yotsuyanagi, Hiroshi, Suzuki, Yutaka, Kawaoka, Yoshihiro

“…EG.5.1 is a subvariant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB variant that is rapidly increasing in prevalence…”
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Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens by Uraki, Ryuta, Imai, Masaki, Ito, Mutsumi, Shime, Hiroaki, Odanaka, Mizuyu, Okuda, Moe, Kawaoka, Yoshihiro, Yamazaki, Sayuri

“…Regulatory T (Treg) cells, which constitute about 5-10% of CD4+T cells expressing Foxp3 transcription factor and CD25(IL-2 receptor α chain), are key…”
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