Search Results - "Ito, Jasmine"
-
1
Factor VIII antibody immune complexes modulate the humoral response to factor VIII in an epitope-dependent manner
Published in Frontiers in immunology (31-08-2023)“…Introduction Soluble antigens complexed with immunoglobulin G (IgG) antibodies can induce robust adaptive immune responses in vitro and in animal models of…”
Get full text
Journal Article -
2
Investigating persistent factor VIII-specific IgM in the humoral immune response to factor VIII
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract Hemophilia A is an X-linked bleeding disorder resulting in bleeding events due to insufficient levels of factor VIII (FVIII). The most significant…”
Get full text
Journal Article -
3
Persistent Splenic-Derived IgM Preferentially Recognize Factor VIIIA2 and C2 Domain Epitopes but Do Not Alter Antibody Production
Published in Journal of thrombosis and haemostasis (28-10-2024)“…The most significant treatment complication for patients with hemophilia A is the development of neutralizing immunoglobin G (IgG), termed inhibitors, against…”
Get full text
Journal Article -
4
Removal of single‐site N‐linked glycans on factor VIII alters binding of domain‐specific monoclonal antibodies
Published in Journal of thrombosis and haemostasis (01-03-2022)“…Background A portion of individuals with hemophilia A develop neutralizing antibodies called inhibitors to glycoprotein factor VIII (FVIII). There are multiple…”
Get full text
Journal Article -
5
The Impact of Anti-Factor VIII A1 and A3 Domain Antibodies in the Immune Reponse to Factor VIII in Patients with Hemophilia a
Published in Blood (08-12-2017)“…Introduction: Up to 30% of treated patients with severe hemophilia A will develop inhibitory antibodies to factor VIII (fVIII inhibitors). These patients…”
Get full text
Journal Article -
6
Very High Dose Factor VIII Needed to Prevent Bleeding in the Presence of a Low Titer Anti-C1 Domain Antibody
Published in Blood (02-12-2016)“…Introduction: Up to 30% of patients with severe hemophilia A will develop inhibitory antibodies to factor VIII (fVIII inhibitors). Patients with congenital…”
Get full text
Journal Article