Search Results - "Ito, Isao"

Offset-free broadband Yb:fiber optical frequency comb for optical clocks by Nakamura, Takuma, Ito, Isao, Kobayashi, Yohei

“…We demonstrate a passively offset-frequency stabilized optical frequency comb centered at 1060 nm. The offset-free comb was achieved through difference…”
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Dupilumab maintenance therapy in an asthmatic patient with coronavirus disease 2019 pneumonia by Tanabe, Naoya, Matsumoto, Hisako, Hamada, Satoshi, Ito, Isao, Hirai, Toyohiro

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Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells by Gotoh, Shimpei, Ito, Isao, Nagasaki, Tadao, Yamamoto, Yuki, Konishi, Satoshi, Korogi, Yohei, Matsumoto, Hisako, Muro, Shigeo, Hirai, Toyohiro, Funato, Michinori, Mae, Shin-Ichi, Toyoda, Taro, Sato-Otsubo, Aiko, Ogawa, Seishi, Osafune, Kenji, Mishima, Michiaki

“…No methods for isolating induced alveolar epithelial progenitor cells (AEPCs) from human embryonic stem cells (hESCs) and induced pluripotent stem cells…”
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Magneto-optic modulator for high bandwidth cavity length stabilization by Nakamura, Takuma, Tani, Shuntaro, Ito, Isao, Kobayashi, Yohei

“…We propose a novel magneto-optical approach for the repetition frequency stabilization of optical frequency combs. We developed a Yb:fiber mode-locked laser…”
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Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma by Tajiri, Tomoko, Matsumoto, Hisako, Jinnai, Makiko, Kanemitsu, Yoshihiro, Nagasaki, Tadao, Iwata, Toshiyuki, Inoue, Hideki, Nakaji, Hitoshi, Oguma, Tsuyoshi, Ito, Isao, Niimi, Akio

“…Airway mucus hypersecretion is an important pathophysiological feature of asthma. MUC5AC and MUC5B are the major secreted polymeric mucins in airways, and…”
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Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study by Sunadome, Hironobu, Matsumoto, Hisako, Izuhara, Yumi, Nagasaki, Tadao, Kanemitsu, Yoshihiro, Ishiyama, Yumi, Morimoto, Chie, Oguma, Tsuyoshi, Ito, Isao, Murase, Kimihiko, Muro, Shigeo, Kawaguchi, Takahisa, Tabara, Yasuharu, Chin, Kazuo, Matsuda, Fumihiko, Hirai, Toyohiro

“…Obesity affects the pathogenesis of various chronic diseases, including asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in…”
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The asymmetry defect of hippocampal circuitry impairs working memory in β2-microglobulin deficient mice by Goto, Kazuhiro, Ito, Isao

“…Left-right (L-R) asymmetry is a fundamental feature of brain function, but the mechanisms underlying functional asymmetry remain largely unknown. We previously…”
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Mice lacking hippocampal left-right asymmetry show non-spatial learning deficits by Shimbo, Akihiro, Kosaki, Yutaka, Ito, Isao, Watanabe, Shigeru

“…•Assessed the significance of circuitry asymmetry on hippocampal-dependent cognition.•Used β2-microglobulin knock-out (β2m KO) mice which lack hippocampal…”
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Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells by Konishi, Satoshi, Gotoh, Shimpei, Tateishi, Kazuhiro, Yamamoto, Yuki, Korogi, Yohei, Nagasaki, Tadao, Matsumoto, Hisako, Muro, Shigeo, Hirai, Toyohiro, Ito, Isao, Tsukita, Sachiko, Mishima, Michiaki

“…Multi-ciliated airway cells (MCACs) play a role in mucociliary clearance of the lung. However, the efficient induction of functional MCACs from human…”
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Drug-induced interstitial lung disease due to over-the-counter cold medicine taken daily for 25 years: a case report by Matsumoto, Masataka, Ito, Isao, Kadowaki, Seizo

“…We report a rare case of drug-induced interstitial lung disease due to over-the-counter cold medicine taken daily for 25 years to clear the patient's head. A…”
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Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma by Kanemitsu, Yoshihiro, Niimi, Akio, Matsumoto, Hisako, Iwata, Toshiyuki, Ito, Isao, Oguma, Tsuyoshi, Inoue, Hideki, Tajiri, Tomoko, Nagasaki, Tadao, Izuhara, Yumi, Petrova, Guergana, Birring, Surinder S., Mishima, Michiaki

“…Gastroesophageal reflux disease (GERD) is known as a common comorbidity of asthma and chronic cough. The impact of GERD symptoms on cough-specific quality of…”
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Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population by Tamari, Mayumi, Hirota, Tomomitsu, Takahashi, Atsushi, Kubo, Michiaki, Tsunoda, Tatsuhiko, Tomita, Kaori, Doi, Satoru, Fujita, Kimie, Miyatake, Akihiko, Enomoto, Tadao, Miyagawa, Takehiko, Adachi, Mitsuru, Tanaka, Hiroshi, Niimi, Akio, Matsumoto, Hisako, Ito, Isao, Masuko, Hironori, Sakamoto, Tohru, Hizawa, Nobuyuki, Taniguchi, Masami, Lima, John J, Irvin, Charles G, Peters, Stephen P, Himes, Blanca E, Litonjua, Augusto A, Tantisira, Kelan G, Weiss, Scott T, Kamatani, Naoyuki, Nakamura, Yusuke

“…Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a…”
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Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids by Kanemitsu, Yoshihiro, MD, Matsumoto, Hisako, MD, PhD, Izuhara, Kenji, MD, PhD, Tohda, Yuji, MD, PhD, Kita, Hideo, MD, PhD, Horiguchi, Takahiko, MD, PhD, Kuwabara, Kazunobu, MD, PhD, Tomii, Keisuke, MD, PhD, Otsuka, Kojiro, MD, PhD, Fujimura, Masaki, MD, PhD, Ohkura, Noriyuki, MD, PhD, Tomita, Katsuyuki, MD, PhD, Yokoyama, Akihito, MD, PhD, Ohnishi, Hiroshi, MD, PhD, Nakano, Yasutaka, MD, PhD, Oguma, Tetsuya, MD, PhD, Hozawa, Soichiro, MD, PhD, Nagasaki, Tadao, MD, Ito, Isao, MD, PhD, Oguma, Tsuyoshi, MD, Inoue, Hideki, MD, Tajiri, Tomoko, MD, Iwata, Toshiyuki, MD, Izuhara, Yumi, MD, Ono, Junya, BS, Ohta, Shoichiro, MD, PhD, Tamari, Mayumi, MD, PhD, Hirota, Tomomitsu, DDS, PhD, Yokoyama, Tetsuji, MD, PhD, Niimi, Akio, MD, PhD, Mishima, Michiaki, MD, PhD

“…Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening in asthmatic airways, and its serum levels reflect airway…”
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Development and validation of a new scoring system for prognostic prediction of community-acquired pneumonia in older adults by Shirata, Masahiro, Ito, Isao, Ishida, Tadashi, Tachibana, Hiromasa, Tanabe, Naoya, Konishi, Satoshi, Oi, Issei, Hamao, Nobuyoshi, Nishioka, Kensuke, Matsumoto, Hisako, Yasutomo, Yoshiro, Kadowaki, Seizo, Ohnishi, Hisashi, Tomioka, Hiromi, Nishimura, Takashi, Hasegawa, Yoshinori, Nakagawa, Atsushi, Hirai, Toyohiro

“…The discriminative power of CURB-65 for mortality in community-acquired pneumonia (CAP) is suspected to decrease with age. However, a useful prognostic…”
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Comprehensive efficacy of omalizumab for severe refractory asthma: a time-series observational study by Tajiri, Tomoko, MD, Niimi, Akio, MD, PhD, Matsumoto, Hisako, MD, PhD, Ito, Isao, MD, PhD, Oguma, Tsuyoshi, MD, Otsuka, Kojiro, MD, PhD, Takeda, Tomoshi, MD, PhD, Nakaji, Hitoshi, MD, PhD, Inoue, Hideki, MD, Iwata, Toshiyuki, MD, Nagasaki, Tadao, MD, Kanemitsu, Yoshihiro, MD, Izuhara, Yumi, MD, Mishima, Michiaki, MD, PhD

“…Abstract Background Omalizumab, a humanized anti-IgE monoclonal antibody, is reportedly an effective treatment for severe allergic asthma. However, there have…”
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In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids by Korogi, Yohei, Gotoh, Shimpei, Ikeo, Satoshi, Yamamoto, Yuki, Sone, Naoyuki, Tamai, Koji, Konishi, Satoshi, Nagasaki, Tadao, Matsumoto, Hisako, Ito, Isao, Chen-Yoshikawa, Toyofumi F., Date, Hiroshi, Hagiwara, Masatoshi, Asaka, Isao, Hotta, Akitsu, Mishima, Michiaki, Hirai, Toyohiro

“…It has been challenging to generate in vitro models of alveolar lung diseases, as the stable culture of alveolar type 2 (AT2) cells has been difficult. Methods…”
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Long-Term Effects of Spironolactone in Peritoneal Dialysis Patients by ITO, Yasuhiko, MIZUNO, Masashi, YUZAWA, Yukio, MATSUBARA, Tatsuaki, MATSUO, Seiichi, SUZUKI, Yasuhiro, TAMAI, Hirofumi, HIRAMATSU, Takeyuki, OHASHI, Hiroshige, ITO, Isao, KASUGA, Hirotake, HORIE, Masanobu, MARUYAMA, Shoichi

“…ESRD treated with dialysis is associated with increased left ventricular hypertrophy, which, in turn, is related to high mortality. Mineralocorticoid receptor…”
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A randomized double-blind placebo-controlled trial of an inhibitor of plasminogen activator inhibitor-1 (TM5614) in mild to moderate COVID-19 by Hirai, Toyohiro, Asano, Koichiro, Ito, Isao, Miyazaki, Yasunari, Sugiura, Hisatoshi, Agirbasli, Mehmet, Kobayashi, Seiichi, Kobayashi, Makoto, Shimada, Daishi, Natsume, Ichiro, Kawasaki, Tsutomu, Ohba, Takehiko, Tajiri, Sakurako, Sakamaki, Fumio, Mineshita, Masamichi, Takihara, Takahisa, Sekiya, Kiyoshi, Tomii, Keisuke, Tomioka, Hiromi, Kita, Hideo, Nishizaka, Yasuo, Fukui, Motonari, Miyata, Toshio, Harigae, Hideo

“…An inhibitor of plasminogen activator inhibitor (PAI)-1, TM5614, inhibited thrombosis, inflammation, and fibrosis in several experimental mouse models. To…”
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Protein C activity as a potential prognostic factor for nursing home-acquired pneumonia by Oi, Issei, Ito, Isao, Tanabe, Naoya, Konishi, Satoshi, Hamao, Nobuyoshi, Shirata, Masahiro, Imai, Seiichiro, Yasutomo, Yoshiro, Kadowaki, Seizo, Matsumoto, Hisako, Hidaka, Yu, Morita, Satoshi, Hirai, Toyohiro

“…Introduction Despite the poor prognosis for nursing home acquired pneumonia (NHAP), a useful prognostic factor is lacking. We evaluated protein C (PC) activity…”
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Prospective multicenter survey for Nursing and Healthcare-associated Pneumonia in Japan by Imamura, Yoshifumi, Miyazaki, Taiga, Watanabe, Akira, Tsukada, Hiroki, Nagai, Hideaki, Hasegawa, Yoshinori, Tomono, Kazunori, Ito, Isao, Teramoto, Shinji, Ishida, Tadashi, Kadota, Jun-ichi, Kohno, Shigeru, Mukae, Hiroshi

“…Nursing and healthcare-associated pneumonia (NHCAP) was proposed by the Japanese Respiratory Society in 2011. However, the clinical characteristics of NHCAP…”
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