Search Results - "Istrate, Monica"

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex by Zhang, Jun, Chalmers, Michael J, Stayrook, Keith R, Burris, Lorri L, Wang, Yongjun, Busby, Scott A, Pascal, Bruce D, Garcia-Ordonez, Ruben D, Bruning, John B, Istrate, Monica A, Kojetin, Douglas J, Dodge, Jeffrey A, Burris, Thomas P, Griffin, Patrick R

“…A comprehensive HDX analysis of the vitamin D receptor–retinoid X receptor (VDR-RXR) reveals extensive allosteric communication within the same polypeptide…”
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The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist by Kumar, Naresh, Solt, Laura A, Conkright, Juliana J, Wang, Yongjun, Istrate, Monica A, Busby, Scott A, Garcia-Ordonez, Ruben D, Burris, Thomas P, Griffin, Patrick R

“…Retinoic acid receptor-related orphan receptors (RORs) regulate a variety of physiological processes including hepatic gluconeogenesis, lipid metabolism,…”
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Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ by Wang, Yongjun, Kumar, Naresh, Nuhant, Philippe, Cameron, Michael D, Istrate, Monica A, Roush, William R, Griffin, Patrick R, Burris, Thomas P

“…The retinoic acid receptor-related receptors (RORs) are members of the nuclear receptor (NR) superfamily of transcription factors. Several NRs are still…”
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Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand by Solt, Laura A., Kumar, Naresh, Nuhant, Philippe, Wang, Yongjun, Lauer, Janelle L., Liu, Jin, Istrate, Monica A., Kamenecka, Theodore M., Roush, William R., Vidović, Dušica, Schürer, Stephan C., Xu, Jihong, Wagoner, Gail, Drew, Paul D., Griffin, Patrick R., Burris, Thomas P.

“…A new class of immunomodulator The nuclear receptors RORα and RORγt (retinoic acid receptor-related orphan receptors α and γt) are essential for the…”
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Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding by Istrate, Monica A., Nussler, Andreas K., Eichelbaum, Michel, Burk, Oliver

“…Induction of the major drug metabolizing enzyme CYP3A4 by xenobiotics contributes to the pronounced interindividual variability of its expression and often…”
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Identification of a Novel Non-retinoid Pan Inverse Agonist of the Retinoic Acid Receptors by Busby, Scott A, Kumar, Naresh, Kuruvilla, Dana S, Istrate, Monica A, Conkright, Juliana J, Wang, Yongjun, Kamenecka, Theodore M, Cameron, Michael D, Roush, William R, Burris, Thomas P, Griffin, Patrick R

“…Retinoids are potent forms of vitamin A and are involved in a broad range of physiological processes and the pharmacological effects of retinoids are primarily…”
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Development of an HTS-compatible assay for discovery of RORα modulators using AlphaScreen® technology by Istrate, Monica A, Spicer, Timothy P, Wang, Yan, Bernard, Jerrold A, Helvering, Leah M, Bocchinfuso, Wayne P, Richardson, Timothy I, Zink, Richard, Kumar, Naresh, Montrose-Rafizadeh, Chahrzad, Dodge, Jeffrey, Hodder, Peter, Griffin, Patrick R

“…The retinoid acid receptor-related orphan receptors (RORs) represent important targets for the treatment of metabolic and immune disorders. Here the authors…”
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A Novel Polymorphism in the Promoter Region of ERBB4 Is Associated with Breast and Colorectal Cancer Risk by ROKAVEC, Matjaz, JUSTENHOVEN, Christina, GLAVAC, Damjan, BRAUCHL, Hiltrud, SCHROTH, Werner, ISTRATE, Monica Adina, HAAS, Susanne, FISCHER, Hans-Peter, VOLLMERT, Caren, ILLIG, Thomas, HAMANN, Ute, KO, Yon-Dschun

“…Purpose: The receptor tyrosine kinase ERBB4/HER4 plays a role in cell division, migration, differentiation, as well as apoptosis, and is frequently…”
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Morphology and side-chain dynamics in hydrated hard α-keratin fibres by 1H solid-state NMR by Melian, Claudiu, Demco, Dan E., Istrate, Monica, Balaceanu, Andreea, Moldovan, Dumitrita, Fechete, Radu, Popescu, Crisan, Möller, Martin

“…Hydration effects on phase composition, side-chain dynamics and domain sizes in hard α-keratin were investigated by 1H wide-line NMR and spin-diffusion. The…”
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Suppression of [T.sub.H]17 differentiation and autoimmunity by a synthetic ROR ligand by Solt, Laura A, Kumar, Naresh, Nuhant, Philippe, Wang, Yongjun, Lauer, Janelle L, Liu, Jin, Istrate, Monica A, Kamenecka, Theodore M, Roush, William R, Vidovic, DuSica, Schurer, Stephan C, Xu, Jihong, Wagoner, Gail, Drew, Paul D, Griffin, Patrick R, Burris, Thomas P

“…T-helper cells that produce interleukin-17 ([T.sub.H]17 cells) are a recently identified [CD4.sup.+] T-cell subset with characterized pathological roles in…”
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Suppression of T^sub H^17 differentiation and autoimmunity by a synthetic ROR ligand by Solt, Laura A, Kumar, Naresh, Nuhant, Philippe, Wang, Yongjun, Lauer, Janelle L, Liu, Jin, Istrate, Monica A, Kamenecka, Theodore M, Roush, William R, Vidovic, Dusica, Schürer, Stephan C, Xu, Jihong, Wagoner, Gail, Drew, Paul D, Griffin, Patrick R, Burris, Thomas P

“…T-helper cells that produce interleukin-17 (T^sub H^17 cells) are a recently identified CD4^sup +^ T-cell subset with characterized pathological roles in…”
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Suppression of T sub(H)17 differentiation and autoimmunity by a synthetic ROR ligand by Solt, Laura A, Kumar, Naresh, Nuhant, Philippe, Wang, Yongjun, Lauer, Janelle L, Liu, Jin, Istrate, Monica A, Kamenecka, Theodore M, Roush, William R, Vidovic, Dusica, Schuerer, Stephan C, Xu, Jihong, Wagoner, Gail, Drew, Paul D, Griffin, Patrick R, Burris, Thomas P

“…T-helper cells that produce interleukin-17 (T sub(H)17 cells) are a recently identified CD4 super(+) T-cell subset with characterized pathological roles in…”
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Identification of a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ, SR1078 by Wang, Yongjun, Kumar, Naresh, Nuhant, Philippe, Cameron, Michael D., Istrate, Monica A., Roush, William R., Griffin, Patrick R., Burris, Thomas P.

“…The retinoic acid receptor-related receptors (RORs) are members of the nuclear receptor (NR) superfamily of transcription factors. Several NRs are still…”
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