Search Results - "Issels, R.D."

13LBA Improved overall survival by adding regional hyperthermia to neo-adjuvant chemotherapy in patients with localized high-risk soft tissue sarcoma (HR-STS): Long-term outcomes of the EORTC 62961/ESHO randomized phase III study by Issels, R.D, Lindner, L.H, Ghadjar, P, Reichardt, P, Hohenberger, P, Verweij, J, Abdel-Rahman, S, Daugaard, S, Salat, C, Vujaskovic, Z, Wessalowski, R, Duerr, H.R, Ploner, F, Mella, O, Schmidt, M, Mansmann, U, Jauch, K.W, Belka, C, Hiddemann, W, Gronchi, A

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PP51 Heat shock of tumor cells at sublethal temperatures causes an immediate phosphorylation of the C-terminal hydrophobic motive of Akt by Kampmann, E, Sujeva, V, Tschoep, K, Paulmann, C, Issels, R.D

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Stellenwert der Hyperthermie im Rahmen der medikamentösen Tumortherapie by Lindner, L.H., Issels, R.D.

“…Zusammenfassung Der klinisch innovative Therapieansatz der Hyperthermie in Kombination mit Chemotherapie gründet sich auf Erkenntnisse der Grundlagenforschung…”
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The cystine cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death by Banjac, A, Perisic, T, Sato, H, Seiler, A, Bannai, S, Weiss, N, Kölle, P, Tschoep, K, Issels, R D, Daniel, P T, Conrad, M, Bornkamm, G W

“…The glutathione-dependent system is one of the key systems regulating cellular redox balance, and thus cell fate. Cysteine, typically present in its oxidized…”
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Pathological grade of tumorregression after neoadjuvant chemotherapy with doxorubicin/ifosfamid and regional hyperthermia correlates with survival outcomes in patients with high-risk soft tissue sarcoma by Schuebbe, G.-E., Knösel, T., Dürr, H.R., Angele, M., Röder, F., Abdel-Rahman, S., Alig, A., Issels, R.D., Di Gioia, D., Lindner, L.H.

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Impact of tumor infiltrating lymphocytes (TILs) on local progression-free (LPFS) and disease-free (DFS) survival in localized high-risk soft tissue sarcoma (HR-STS) after neo-adjuvant chemotherapy (NAC) with regional hyperthermia (RHT) by Issels, R.D., Kampmann, E., Bücklein, V., Nössner, E., Lindner, L.H., Schmidt, M., Mansmann, U., Hiddemann, W., Subklewe, M., Knösel, T.

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Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study by Issels, R.D, Abdel-Rahman, S, Wendtner, C.-M, Falk, M.H, Kurze, V, Sauer, H, Aydemir, U, Hiddemann, W

“…In this phase II study, activity and safety of neoadjuvant regional hyperthermia (RHT) combined with chemotherapy was investigated in 59 patients with primary…”
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Differential effects of ifosfamide on dendritic cell-mediated stimulation of T cell interleukin-2 production, natural killer cell cytotoxicity and interferon-γ production by Kuppner, M.C, Bleifuß, E, Noessner, E, Mocikat, R, Hesler, C. von, Mayerhofer, C, Issels, R.D

“…Ifosfamide is a DNA-alkylating agent used frequently in chemotherapy of human malignancies. Ifosfamide and its major decomposition products deplete…”
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Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia by Wendtner, C.-M., Abdel-Rahman, S., Baumert, J., Falk, M.H., Krych, M., Santl, M., Hiddemann, W., Issels, R.D.

“…The efficacy of thermochemotherapy in adult patients with primary, recurrent or inadequately resected non-metastatic high-risk soft-tissue sarcomas (STS) was…”
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Cancer and the heat shock response by Fuller, K J, Issels, R D, Slosman, D O, Guillet, J G, Soussi, T, Polla, B S

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Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults by Wendtner, C.-M., Abdel-Rahman, S., Baumert, J., Falk, M.H., Krych, M., Santl, M., Hiddemann, W., Issels, R.D.

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Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults by Issels, R.D, Abdel-Rahman, S, Wendtner, C.-M, Falk, M.H, Kurze, V, Sauer, H, Aydemir, U, Hiddemann, W

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Ifosfamide with regional hyperthermia in soft-tissue sarcomas by Schlemmer, M, Wendtner, C M, Issels, R D

“…For high-risk soft tissue sarcomas (HR-STS) of adults, new treatment strategies are needed to improve outcome with regard to local control and overall…”
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Initial response to neoadjuvant chemotherapy combined with regional hyperthermia (RHT) in high-risk soft tissue sarcomas (HR-STS) of adults and its correlation to survival parameters by Issels, R.D., Abdel-Rahman, S., Falk, M.H., Salat, C., Ochmann, O., Reiser, M., Hiddemann, W.

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Toxicity profile of a high-dose (HD) chemotherapy regimen with peripheral blood stem cell rescue (PBSCR) for adults with soft tissue sarcoma (STS) by Falk, M.H., Salat, C., Mempel, W., Kolb, H., Theiss, F., Schneller, F., Peschel, C., Rommel, F., Hiddemann, W., Issels, R.D.

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Regulation of deoxyctidine kinase by deoxyctidine and deoxyctidine-5′ triphosphate in whole cells by Heinemann, V., Schulz, L., Issels, R.D., Wilmanns, W.

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862 CD3 negative large granular lymphocytes recognize an immunogenic determinant associated with the 72 KD heat shock protein (HSP) on human sarcoma cells by Multhoff, G., Botzler, C., Wiesnet, M., Wilmanns, W., Issels, R.D.

“…Traditionally, heat shock proteins (HSP) are believed to be located intracellularly, where they perform a variety of chaperoning function. However, recent…”
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A stress inducible HSP72 cell surface expression is observed selectively on human tumor cells by Wiesner, M., Multhoff, G., Botzler, C., Wilmanns, W., Issels, R.D.

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A heat inducible HSP72 associated immunogenic determinant act as a tumor specific recognition structure for NK cells by Botzler, C., Multhoff, G., Wiesnet, M., Wilmanns, W., Issels, R.D.

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Feasibility and morbidity of combined hyperthermia and radiochemotherapy in recurrent rectal cancer--preliminary results by Schaffer, M, Krych, M, Pachmann, S, Abdel-Rahman, S, Schaffer, P M, Ertl-Wagner, B, D hmke, E, Issels, R D

“…The local recurrence rate of colorectal cancer has been significantly reduced due to the use of combined radiochemotherapy. Despite this improvement regarding…”
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