Search Results - "Israel Fernandez-Cadenas"

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality by Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Cordioli, Mattia, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Niemi, Mari E.K., Palom, Adriana, Ellinghaus, David, Khan, Atlas, Martínez-Bueno, Manuel, Rolker, Selina, Amitrano, Sara, Roade Tato, Luisa, Fava, Francesca, Spinner, Christoph D., Prati, Daniele, Bernardo, David, Garcia, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesus M., Frithiof, Robert, Kiryluk, Krzysztof, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C., Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, Hov, Johannes R., Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M., Ludwig, Kerstin U., Buti, Maria, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Franke, Andre, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Richards, J. Brent, Ganna, Andrea

“…BACKGROUND. There is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition…”
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Contribution of “Omic” Studies to the Understanding of Cadasil. A Systematic Review by Muiño, Elena, Fernández-Cadenas, Israel, Arboix, Adrià

“…CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a small vessel disease caused by mutations in NOTCH3…”
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Systematic Review of Cysteine-Sparing NOTCH3 Missense Mutations in Patients with Clinical Suspicion of CADASIL by Muiño, Elena, Gallego-Fabrega, Cristina, Cullell, Natalia, Carrera, Caty, Torres, Nuria, Krupinski, Jurek, Roquer, Jaume, Montaner, Joan, Fernández-Cadenas, Israel

“…CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is caused by mutations in the gene, affecting the number…”
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Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage by Falcone, Guido J., Kirsch, Elayna, Acosta, Julian N., Noche, Rommell B., Leasure, Audrey, Marini, Sandro, Chung, Jaeyoon, Selim, Magdy, Meschia, James F., Brown, Devin L., Worrall, Bradford B., Tirschwell, David L., Jagiella, Jeremiasz M., Schmidt, Helena, Jimenez‐Conde, Jordi, Fernandez‐Cadenas, Israel, Lindgren, Arne, Slowik, Agnieszka, Gill, Dipender, Holmes, Michael, Phuah, Chia‐Ling, Petersen, Nils H., Matouk, MD, Charles N., Gunel, Murat, Sansing, Lauren, Bennett, Derrick, Chen, Zhengming, Sun, Luan L., Clarke, Robert, Walters, Robin G., Gill, Thomas M., Biffi, Alessandro, Kathiresan, Sekar, Langefeld, Carl D., Woo, Daniel, Rosand, Jonathan, Sheth, Kevin N., Anderson, Christopher D.

“…Objective Observational studies point to an inverse correlation between low‐density lipoprotein (LDL) cholesterol levels and risk of intracerebral hemorrhage…”
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Biological age is better than chronological as predictor of 3-month outcome in ischemic stroke by Soriano-Tárraga, Carolina, Mola-Caminal, Marina, Giralt-Steinhauer, Eva, Ois, Angel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Gómez-González, Alejandra, Vivanco-Hidalgo, Rosa M, Fernández-Cadenas, Israel, Cullell, Natalia, Roquer, Jaume, Jiménez-Conde, Jordi

“…OBJECTIVE:To analyze the effect of age-related DNA methylation changes in multiple cytosine-phosphate-guanine (CpG) sites (biological age [b-age]) on patient…”
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Variants at APOE influence risk of deep and lobar intracerebral hemorrhage by Biffi, Alessandro, Sonni, Akshata, Anderson, Christopher D., Kissela, Brett, Jagiella, Jeremiasz M., Schmidt, Helena, Jimenez-Conde, Jordi, Hansen, Björn M., Fernandez-Cadenas, Israel, Cortellini, Lynelle, Ayres, Alison, Schwab, Kristin, Juchniewicz, Karol, Urbanik, Andrzej, Rost, Natalia S., Viswanathan, Anand, Seifert-Held, Thomas, Stoegerer, Eva-Maria, Tomás, Marta, Rabionet, Raquel, Estivill, Xavier, Brown, Devin L., Silliman, Scott L., Selim, Magdy, Worrall, Bradford B., Meschia, James F., Montaner, Joan, Lindgren, Arne, Roquer, Jaume, Schmidt, Reinhold, Greenberg, Steven M., Slowik, Agnieszka, Broderick, Joseph P., Woo, Daniel, Rosand, Jonathan

“…Objective Prior studies investigating the association between APOE alleles ε2/ε4 and risk of intracerebral hemorrhage (ICH) have been inconsistent and limited…”
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Genome-Wide Studies in Ischaemic Stroke: Are Genetics Only Useful for Finding Genes? by Gallego-Fabrega, Cristina, Muiño, Elena, Cárcel-Márquez, Jara, Llucià-Carol, Laia, Lledós, Miquel, Martín-Campos, Jesús M, Cullell, Natalia, Fernández-Cadenas, Israel

“…Ischaemic stroke is a complex disease with some degree of heritability. This means that heritability factors, such as genetics, could be risk factors for…”
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ICA1L Is Associated with Small Vessel Disease: A Proteome-Wide Association Study in Small Vessel Stroke and Intracerebral Haemorrhage by Cullell, Natalia, Gallego-Fábrega, Cristina, Cárcel-Márquez, Jara, Muiño, Elena, Llucià-Carol, Laia, Lledós, Miquel, Martín-Campos, Jesús M, Molina, Jessica, Casas, Laura, Almeria, Marta, Fernández-Cadenas, Israel, Krupinski, Jerzy

“…Small vessel strokes (SVS) and intracerebral haemorrhages (ICH) are acute outcomes of cerebral small vessel disease (SVD). Genetic studies combining both…”
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Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release by Cuadrado, Eloy, Ortega, Laura, Hernández‐Guillamon, Mar, Penalba, Anna, Fernández‐Cadenas, Israel, Rosell, Anna, Montaner, Joan

“…Recombinant tissue plasminogen activator (t‐PA), the only approved stroke treatment, is used for clot lysis within the occluded brain artery. Unfortunately,…”
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Identification of 20 novel loci associated with ischaemic stroke. Epigenome-wide association study by Soriano-Tárraga, Carolina, Lazcano, Uxue, Giralt-Steinhauer, Eva, Avellaneda-Gómez, Carla, Ois, Ángel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Gómez-González, Alejandra, Fernández-Sanlés, Alba, Elosua, Roberto, Fernández-Cadenas, Israel, Cullell, Natalia, Montaner, Joan, Moran, Sebastian, Esteller, Manel, Jiménez-Conde, Jordi, Roquer, Jaume

“…DNA methylation is dynamic, varies throughout the life course, and its levels are influenced by lifestyle and environmental factors, as well as by genetic…”
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DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial by Davis Armstrong, Nicole M, Chen, Wei-Min, Hsu, Fang-Chi, Brewer, Michael S, Cullell, Natalia, Fernández-Cadenas, Israel, Williams, Stephen R, Sale, Michèle M, Worrall, Bradford B, Keene, Keith L

“…Aberrant DNA methylation profiles have been implicated in numerous cardiovascular diseases; however, few studies have investigated how these epigenetic…”
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Leveraging Genetic Data to Elucidate the Relationship Between COVID-19 and Ischemic Stroke by Zuber, Verena, Cameron, Alan, Myserlis, Evangelos P, Bottolo, Leonardo, Fernandez-Cadenas, Israel, Burgess, Stephen, Anderson, Christopher D, Dawson, Jesse, Gill, Dipender

“…Background The relationship between COVID-19 and ischemic stroke is poorly understood due to potential unmeasured confounding and reverse causation. We aimed…”
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Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes by Llucià-Carol, Laia, Muiño, Elena, Cullell, Natalia, Cárcel-Márquez, Jara, Lledós, Miquel, Gallego-Fabrega, Cristina, Martin-Campos, Jesús, Martí-Fàbregas, Joan, Aguilera-Simón, Ana, Planas, Anna M., DeDiego, Marta L., de Felipe Mimbrera, Alicia, Masjuan, Jaime, García-Madrona, Sebastián, Segura, Tomás, González-Villar, Esther, Serrano-Heras, Gemma, Domínguez Mayoral, Ana, Menéndez-Valladares, Paloma, Montaner, Joan, Migeotte, Isabelle, Rahmouni, Souad, Darcis, Gilles, Bernardo, David, Rojo, Silvia, Schulte, Eva C., Protzer, Ulrike, Fricke, Lisa, Winter, Christof, Niemi, Mari E. K., Cordioli, Mattia, Delgado, Pilar, Fernández-Cadenas, Israel

“…We aimed to analyse whether patients with ischaemic stroke (IS) occurring within eight days after the onset of COVID-19 (IS-COV) are associated with a specific…”
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Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment by Muiño, Elena, Maisterra, Olga, Jiménez-Balado, Joan, Cullell, Natalia, Carrera, Caty, Torres-Aguila, Nuria P., Cárcel-Márquez, Jara, Gallego-Fabrega, Cristina, Lledós, Miquel, González-Sánchez, Jonathan, Olmos-Alpiste, Ferran, Espejo, Eva, March, Álvaro, Pujol, Ramón, Rodríguez-Campello, Ana, Romeral, Gemma, Krupinski, Jurek, Martí-Fàbregas, Joan, Montaner, Joan, Roquer, Jaume, Fernández-Cadenas, Israel

“…CADASIL is a small vessel disease caused by mutations in NOTCH3 that lead to an odd number of cysteines in the EGF-like repeat domain, causing protein…”
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Global DNA methylation of ischemic stroke subtypes by Soriano-Tárraga, Carolina, Jiménez-Conde, Jordi, Giralt-Steinhauer, Eva, Mola, Marina, Ois, Angel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Fernández-Cadenas, Israel, Carrera, Caty, Montaner, Joan, Elosua, Roberto, Roquer, Jaume

“…Ischemic stroke (IS), a heterogeneous multifactorial disorder, is among the leading causes of mortality and long-term disability in the western world…”
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Limb-girdle muscular dystrophy 1F is caused by a microdeletion in the transportin 3 gene by MELIA, Maria J, KUBOTA, Akatsuki, GARCIA-ARUMI, Elena, ANDREU, Antoni L, NAVARRO, Carmen, HIRANO, Michio, MARTI, Ramon, ORTOLANO, Saida, VILCHEZ, Juan J, GAMEZ, Josep, TANJ I, Kurenai, BONILLA, Eduardo, PALENZUELA, Lluís, FERNANDEZ-CADENAS, Israel, PRISTOUPILOVA, Anna

“…In 2001, we reported linkage of an autosomal dominant form of limb-girdle muscular dystrophy, limb-girdle muscular dystrophy 1F, to chromosome 7q32.1-32.2, but…”
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Brain perihematoma genomic profile following spontaneous human intracerebral hemorrhage by Rosell, Anna, Vilalta, Anna, García-Berrocoso, Teresa, Fernández-Cadenas, Israel, Domingues-Montanari, Sophie, Cuadrado, Eloy, Delgado, Pilar, Ribó, Marc, Martínez-Sáez, Elena, Ortega-Aznar, Arantxa, Montaner, Joan

“…Spontaneous intracerebral hemorrhage (ICH) represents about 15% of all strokes and is associated with high mortality rates. Our aim was to identify the gene…”
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DNA methylation and stroke prognosis: an epigenome-wide association study by Jiménez-Balado, Joan, Fernández-Pérez, Isabel, Gallego-Fábrega, Cristina, Lazcano, Uxue, Soriano-Tárraga, Carolina, Vallverdú-Prats, Marta, Mola-Caminal, Marina, Rey-Álvarez, Lucía, Macias-Gómez, Adrià, Suárez-Pérez, Antoni, Giralt-Steinhauer, Eva, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Ois, Ángel, Esteller, Manel, Roquer, Jaume, Fernández-Cadenas, Israel, Jiménez-Conde, Jordi

“…Stroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there is a significant variability among individuals…”
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Progression of Symptomatic Intracranial Large Artery Atherosclerosis Is Associated With a Proinflammatory State and Impaired Fibrinolysis by ARENILLAS, Juan F, ALVAREZ-SABIN, José, MONTANER, Joan, MOLINA, Carlos A, CHACON, Pilar, FERNANDEZ-CADENAS, Israel, RIBO, Marc, DELGADO, Pilar, RUBIERA, Marta, PENALBA, Anna, ROVIRA, Alex

“…The molecular pathways involved in the progression of intracranial large artery atherosclerosis (ILA) are largely unknown. Our objective was to prospectively…”
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Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis by Medina-Dols, Aina, Cañellas, Guillem, Capó, Toni, Solé, Montse, Mola-Caminal, Marina, Cullell, Natalia, Jaume, Marina, Nadal-Salas, Laura, Llinàs, Jaume, Gómez, Lluis, Tur, Silvia, Jiménez, Carmen, Díaz, Rosa M., Carrera, Caty, Muiño, Elena, Gallego-Fabrega, Cristina, Soriano-Tárraga, Carolina, Ruiz-Guerra, Laura, Pol-Fuster, Josep, Asensio, Víctor, Muncunill, Josep, Fleischer, Aarne, Iglesias, Amanda, Giralt-Steinhauer, Eva, Lazcano, Uxue, Fernández-Pérez, Isabel, Jiménez-Balado, Joan, Gabriel-Salazar, Marina, Garcia-Gabilondo, Miguel, Lei, Ting, Torres-Aguila, Nuria-Paz, Cárcel-Márquez, Jara, Lladó, Jerònia, Olmos, Gabriel, Rosell, Anna, Montaner, Joan, Planas, Anna M., Rabionet, Raquel, Hernández-Guillamon, Mar, Jiménez-Conde, Jordi, Fernández-Cadenas, Israel, Vives-Bauzá, Cristòfol

“…Through GWAS studies we identified PATJ associated with functional outcome after ischemic stroke (IS). The aim of this study was to determine PATJ role in…”
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