Search Results - "Israel, Mark A"

Glioma Cell Secretion: A Driver of Tumor Progression and a Potential Therapeutic Target by Almiron Bonnin, Damian A, Havrda, Matthew C, Israel, Mark A

“…Cellular secretion is an important mediator of cancer progression. Secreted molecules in glioma are key components of complex autocrine and paracrine pathways…”
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Activity of immunoproteasome inhibitor ONX-0914 in acute lymphoblastic leukemia expressing MLL–AF4 fusion protein by Jenkins, Tyler W., Downey-Kopyscinski, Sondra L., Fields, Jennifer L., Rahme, Gilbert J., Colley, William C., Israel, Mark A., Maksimenko, Andrey V., Fiering, Steven N., Kisselev, Alexei F.

“…Proteasome inhibitors bortezomib and carfilzomib are approved for the treatment of multiple myeloma and mantle cell lymphoma and have demonstrated clinical…”
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A Retrospective Analysis of the AT&T/Time Warner Merger by Carlton, Dennis W., Giozov, Georgi V., Israel, Mark A., Shampine, Allan L.

“…This article provides a retrospective of a litigated vertical merger: the 2018 AT&T/Time Warner merger, which was challenged by the US Department of Justice,…”
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Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma by HARRIS, Molly A, YANG, Hyuna, LOW, Benjamin E, MUKHERJE, Joydeep, GUHA, Abhijit, BRONSON, Roderick T, SHULTZ, Leonard D, ISRAEL, Mark A, YUN, Kyuson

“…The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level…”
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Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells by Sullivan, Jaclyn M., Havrda, Matthew C., Kettenbach, Arminja N., Paolella, Brenton R., Zhang, Zhonghua, Gerber, Scott A., Israel, Mark A.

“…Inhibitor of DNA binding proteins (Id1‐Id4) function to inhibit differentiation and promote proliferation of many different cell types. Among the Id family…”
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Gene Expression Profiling Reveals Molecularly and Clinically Distinct Subtypes of Glioblastoma Multiforme by Liang, Yu, Diehn, Maximilian, Watson, Nathan, Bollen, Andrew W., Aldape, Ken D., Nicholas, M. Kelly, Lamborn, Kathleen R., Berger, Mitchel S., Botstein, David, Brown, Patrick O., Israel, Mark A., Cavenee, Webster K.

“…Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability,…”
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Id4 regulates neural progenitor proliferation and differentiation in vivo by Yun, Kyuson, Mantani, Akio, Garel, Sonia, Rubenstein, John, Israel, Mark A

“…The mechanisms that determine whether a precursor cell re-enters the cell cycle or exits and differentiates are crucial in determining the types and numbers of…”
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A Role for Id2 in Regulating Photic Entrainment of the Mammalian Circadian System by Duffield, Giles E., Watson, Nathan P., Mantani, Akio, Peirson, Stuart N., Robles-Murguia, Maricela, Loros, Jennifer J., Israel, Mark A., Dunlap, Jay C.

“…Inhibitor of DNA binding genes (Id1–Id4) encode helix-loop-helix (HLH) transcriptional repressors associated with development and tumorigenesis [1, 2], but…”
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Id2 Is Required for Specification of Dopaminergic Neurons during Adult Olfactory Neurogenesis by Havrda, Matthew C, Harris, Brent T, Mantani, Akio, Ward, Nora M, Paolella, Brenton R, Cuzon, Verginia C, Yeh, Hermes H, Israel, Mark A

“…Understanding the biology of adult neural stem cells has important implications for nervous system development and may contribute to our understanding of…”
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ID2 (Inhibitor of DNA Binding 2) Is a Rhythmically Expressed Transcriptional Repressor Required for Circadian Clock Output in Mouse Liver by Hou, Tim Y., Ward, Sarah M., Murad, Joana M., Watson, Nathan P., Israel, Mark A., Duffield, Giles E.

“…Id2 is a helix-loop-helix transcription factor gene expressed in a circadian manner in multiple tissues with a phase-locked relationship with canonical clock…”
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EGFR overexpression and radiation response in glioblastoma multiforme by Barker, 2nd, F G, Simmons, M L, Chang, S M, Prados, M D, Larson, D A, Sneed, P K, Wara, W M, Berger, M S, Chen, P, Israel, M A, Aldape, K D

“…Recent studies have suggested relative radioresistance in glioblastoma multiforme (GM) tumors in older patients, consistent with their shorter survival. Two…”
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Characterization of MicroRNA expression levels and their biological correlates in human cancer cell lines by GAUR, Arti, JEWELL, David A, YU LIANG, RIDZON, Dana, MOORE, Jason H, CAIFU CHEN, AMBROS, Victor R, ISRAEL, Mark A

“…MicroRNAs are small noncoding RNAs that function by regulating target gene expression posttranscriptionally. They play a critical role in developmental and…”
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Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma by Mao, Pingping, Hever-Jardine, Mary P, Rahme, Gilbert J, Yang, Eric, Tam, Janice, Kodali, Anita, Biswal, Bijesh, Fadul, Camilo E, Gaur, Arti, Israel, Mark A, Spinella, Michael J

“…STK17A is a relatively uncharacterized member of the death-associated protein family of serine/threonine kinases which have previously been associated with…”
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Effects of the 2010 Horizontal Merger Guidelines on Merger Review: Based on Ten Years of Practical Experience by Carlton, Dennis W., Israel, Mark A.

“…We assess how the 2010 Merger Guidelines have been applied by agencies and courts. We conclude that: Increased reliance on direct evidence of market power has…”
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Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation by CONG RAN, HUAN LIU, HITOSHI, Yasuyuki, ISRAEL, Mark A

“…The differences in glucose metabolism that distinguish most malignant and normal tissues have called attention to the importance of understanding the molecular…”
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Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis by Maruyama, Haruhisa, Kleeff, Jörg, Wildi, Stefan, Friess, Helmut, Büchler, Markus W., Israel, Mark A., Korc, Murray

“…Id proteins antagonize basic helix-loop-helix proteins, inhibit differentiation, and enhance cell proliferation. In this study we compared the expression of…”
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A recombinant lentiviral PDGF-driven mouse model of proneural glioblastoma by Rahme, Gilbert J, Luikart, Bryan W, Cheng, Chao, Israel, Mark A

“…Mouse models of glioblastoma (GBM), the most aggressive primary brain tumor, are critical for understanding GBM pathology and can contribute to the preclinical…”
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PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells by Rahme, Gilbert J, Zhang, Zhonghua, Young, Alison L, Cheng, Chao, Bivona, Eric J, Fiering, Steven N, Hitoshi, Yasuyuki, Israel, Mark A

“…Glioblastoma is the most aggressive primary brain tumor and responds poorly to currently available therapies. Transcriptomic characterization of glioblastoma…”
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Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo by Gaur, Arti B., Holbeck, Susan L., Colburn, Nancy H., Israel, Mark A.

“…MicroRNAs (miRNAs) are small, noncoding RNAs that play a critical role in developmental and physiological processes and are implicated in the pathogenesis of…”
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Characterizing the heterogeneity in 5-aminolevulinic acid-induced fluorescence in glioblastoma by Almiron Bonnin, Damian A, Havrda, Matthew C, Lee, Myung Chang, Evans, Linton, Ran, Cong, Qian, David C, Harrington, Lia X, Valdes, Pablo A, Cheng, Chao, Amos, Chris I, Harris, Brent T, Paulsen, Keith D, Roberts, David W, Israel, Mark A

“…5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is an effective surgical adjunct for the intraoperative identification of tumor…”
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