Search Results - "Israel, David"

Discovering Drugs with DNA‐Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase by Belyanskaya, Svetlana L., Ding, Yun, Callahan, James F., Lazaar, Aili L., Israel, David I.

“…DNA‐encoded chemical library technology was developed with the vision of its becoming a transformational platform for drug discovery. The hope was that a new…”
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Benchmark policies for utility-carrying queues with impatience by Deutsch, Yael, David, Israel

“…Men and jobs alike are characterized by a single trait , which may take on categorical values according to given population frequencies. Men arrive to the…”
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The critical points of production rate under vendor–buyer coordination: explicit solutions by David, Israel, Herbon, Avi

“…This paper revisits the deterministic joint vendor–buyer production‐inventory problem and assumes that the production rate can be controlled. To guard against…”
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A method for estimating binding affinity from primary DEL selection data by Chen, Qiuxia, Hall, Justin, Foley, Timothy L., Wan, Jinqiao, Li, You, Israel, David I.

“…DEL selections are binding assays conducted with mixtures of chemically diverse DNA-tagged ligands and a screening target. DEL selections use DNA sequence…”
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The Human Activity Radar Challenge: benchmarking based on the 'Radar signatures of human activities' dataset from Glasgow University by Yang, Shufan, Kernec, Julien Le, Romain, Olivier, Fioranelli, Francesco, Cadart, Pierre, Fix, Jeremy, Ren, Chenfang, Manfredi, Giovanni, Letertre, Thierry, Saenz, Israel David Hinostroza, Zhang, Jifa, Liang, Huaiyuan, Wang, Xiangrong, Li, Gang, Chen, Zhaoxi, Liu, Kang, Chen, Xiaolong, Li, Jiefang, Wu, Xing, Chen, Yichang, Jin, Tian

“…Radar is an extremely valuable sensing technology for detecting moving targets and measuring their range, velocity, and angular positions. When people are…”
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The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity by Colangeli, Luca, Escobar Marcillo, David Israel, Simonelli, Valeria, Iorio, Egidio, Rinaldi, Tommaso, Sbraccia, Paolo, Fortini, Paola, Guglielmi, Valeria

“…Adipose tissue (AT) dysregulation is a key process in the pathophysiology of obesity and its cardiometabolic complications, but even if a growing body of…”
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Plasma membrane aquaporins of the PIP1 and PIP2 subfamilies facilitate hydrogen peroxide diffusion into plant roots by Israel, David, Lee, Seong Hee, Robson, Thomas Matthew, Zwiazek, Janusz Jerzy

“…The permeability of plasma membrane aquaporins (PIPs) to small solutes other than water greatly diversifies their potential functions in plant development and…”
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Optimal manufacturer's cost sharing ratio, shipping policy and production rate – A two-echelon supply chain by Herbon, Avi, David, Israel

“…We analyze an integrated inventory supply chain and seek the optimal production lot, optimal production rate, and optimal (integer) number of shipments per…”
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Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach by Chen, Qiuxia, Liu, Chuan, Wang, Wei, Meng, Xiaoyun, Cheng, Xuemin, Li, Xianyang, Cai, Longying, Luo, Linfu, He, Xu, Qu, Huan, Luo, Jing, Wei, Hong, Gao, Sen, Liu, Guansai, Wan, Jinqiao, Israel, David I., Li, Jin, Dou, Dengfeng

“…The proteolysis targeting chimera (PROTAC) strategy results in the down-regulation of unwanted protein(s) for disease treatment. In the PROTAC process, a…”
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Discovering innovation opportunities based on SECI model: reconfiguring knowledge dynamics of the agricultural artisan production of agave-mezcal, using emerging technologies by Flores Torres, Columba Lisset, Olvera-Vargas, Luis Alberto, Sánchez Gómez, Julia, Contreras-Medina, David Israel

“…Purpose Following the recommendation of the food and agriculture organization of the United Nations in agricultural innovation, for taking advantage of…”
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A simple method for determining compound affinity and chemical yield from DNA-encoded library selections by Hall, Justin, Foley, Timothy L., Chen, Qiuxia, Israel, David I., Xu, Yanshan, Ford, Kristin K., Xie, Ping, Fan, Jing, Wan, Jinqiao

“…DNA-encoded libraries (DELs) can contain billions of unique chemical species; selecting against such large inputs, it is typical to find more candidate binders…”
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The dual nature of DNA damage response in obesity and bariatric surgery-induced weight loss by Escobar Marcillo, David Israel, Guglielmi, Valeria, Privitera, Grete Francesca, Signore, Michele, Simonelli, Valeria, Manganello, Federico, Dell’Orso, Ambra, Laterza, Serena, Parlanti, Eleonora, Pulvirenti, Alfredo, Marcon, Francesca, Siniscalchi, Ester, Fertitta, Veronica, Iorio, Egidio, Varì, Rosaria, Nisticò, Lorenza, Valverde, Mahara, Sbraccia, Paolo, Dogliotti, Eugenia, Fortini, Paola

“…This novel study applies targeted functional proteomics to examine tissues and cells obtained from a cohort of individuals with severe obesity who underwent…”
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Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals by Talukdar, Fazlur Rahman, Escobar Marcillo, David Israel, Laskar, Ruhina Shirin, Novoloaca, Alexei, Cuenin, Cyrille, Sbraccia, Paolo, Nisticò, Lorenza, Guglielmi, Valeria, Gheit, Tarik, Tommasino, Massimo, Dogliotti, Eugenia, Fortini, Paola, Herceg, Zdenko

“…Obesity is a multifactorial and chronic condition of growing universal concern. It has recently been reported that bariatric surgery is a more successful…”
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Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists by Kollmann, Christopher S., Bai, Xiaopeng, Tsai, Ching-Hsuan, Yang, Hongfang, Lind, Kenneth E., Skinner, Steven R., Zhu, Zhengrong, Israel, David I., Cuozzo, John W., Morgan, Barry A., Yuki, Koichi, Xie, Can, Springer, Timothy A., Shimaoka, Motomu, Evindar, Ghotas

“…Encoded library technology (ELT) was utilized to identify a class of compounds that disrupt the interaction between lymphocyte function-associated antigen-1…”
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The Epidemiology of Inflammatory Bowel Disease in Canada: A Population-Based Study by BERNSTEIN, Charles N, WAJDA, Andre, SVENSON, Lawrence W, MACKENZIE, Adrian, KOEHOORN, Mieke, JACKSON, Maureen, FEDORAK, Richard, ISRAEL, David, BLANCHARD, James F

“…Previously, we have demonstrated a high incidence and prevalence of Crohn's disease (CD) and ulcerative colitis (UC) in the Canadian province of Manitoba…”
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Interactions Between the Dietary Polyunsaturated Fatty Acid Ratio and Genetic Factors Determine Susceptibility to Pediatric Crohn's Disease by Costea, Irina, Mack, David R, Lemaitre, Rozenn N, Israel, David, Marcil, Valerie, Ahmad, Ali, Amre, Devendra K

“…Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are…”
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LunaNet: a Flexible and Extensible Lunar Exploration Communications and Navigation Infrastructure by Israel, David J., Mauldin, Kendall D., Roberts, Christopher J., Mitchell, Jason W., Pulkkinen, Antti A., Cooper, La Vida D., Johnson, Michael A., Christe, Steven D., Gramling, Cheryl J.

“…NASA has set the ambitious goal of establishing a sustainable human presence on the Moon. Diverse commercial and international partners are engaged in this…”
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Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT) by Ding, Yun, Belyanskaya, Svetlana, DeLorey, Jennifer L., Messer, Jeffrey A., Joseph Franklin, G., Centrella, Paolo A., Morgan, Barry A., Clark, Matthew A., Skinner, Steven R., Dodson, Jason W., Li, Peng, Marino, Joseph P., Israel, David I.

“…[Display omitted] Inhibition of soluble epoxide hydrolase (sEH) has recently emerged as a new approach to treat cardiovascular disease and respiratory disease…”
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Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor by Wu, Zining, Graybill, Todd L, Zeng, Xin, Platchek, Michael, Zhang, Jean, Bodmer, Vera Q, Wisnoski, David D, Deng, Jianghe, Coppo, Frank T, Yao, Gang, Tamburino, Alex, Scavello, Genaro, Franklin, G. Joseph, Mataruse, Sibongile, Bedard, Katie L, Ding, Yun, Chai, Jing, Summerfield, Jennifer, Centrella, Paolo A, Messer, Jeffrey A, Pope, Andrew J, Israel, David I

“…DNA-encoded small-molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, this technology has…”
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Effects of the Rho GTPase‐activating toxin CNF1 on fibroblasts derived from Rett syndrome patients: A pilot study by Cittadini, Camilla, Germinario, Elena Angela Pia, Maroccia, Zaira, Cosentino, Livia, Maselli, Valeria, Gambardella, Lucrezia, Giambenedetti, Massimo, Guidotti, Marco, Travaglione, Sara, Fallerini, Chiara, Renieri, Alessandra, Marcillo, David Israel Escobar, Ricceri, Laura, Fortini, Paola, De Filippis, Bianca, Fiorentini, Carla, Fabbri, Alessia

“…The bacterial product CNF1, through its action on the Rho GTPases, is emerging as a modulator of crucial signalling pathways involved in selected neurological…”
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