Leveraging on the genomics and immunopathology of SARS-CoV-2 for vaccines development: prospects and challenges

The incidence and case-fatality rates (CFRs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the etiological agent for Coronavirus Disease 2019 (COVID-19), have been rising unabated. Even though the entire world has been implementing infection prevention and control measur...

Full description

Saved in:

Bibliographic Details
Published in:	Human vaccines & immunotherapeutics Vol. 17; no. 3; pp. 620 - 637
Main Authors:	Abdullahi, Idris Nasir, Emeribe, Anthony Uchenna, Adekola, Hafeez Aderinsayo, Abubakar, Sharafudeen Dahiru, Dangana, Amos, Shuwa, Halima Ali, Nwoba, Sunday Theophilus, Mustapha, Jelili Olaide, Haruna, Muyideen Titilope, Olowookere, Kafayat Adepeju, Animasaun, Olawale Sunday, Ugwu, Charles Egede, Onoja, Solomon Oloche, Gadama, Abdullahi Sani, Mohammed, Musa, Daneji, Isa Muhammad, Amadu, Dele Ohinoyi, Ghamba, Peter Elisha, Onukegbe, Nkechi Blessing, Shehu, Muhammad Sagir, Isomah, Chiladi, Babayo, Adamu, Ahmad, Abdurrahman El-Fulaty
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 04-03-2021 Taylor & Francis Group
Subjects:	Animals COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 - virology COVID-19 Vaccines - immunology Genomics - methods Host-virus interaction Humans Pandemics - prevention & control Review SARS-CoV-2 SARS-CoV-2 - genetics SARS-CoV-2 - immunology SARS-CoV-2 - pathogenicity Vaccine discovery COVID-19 SARS-CoV-2 Host-virus interaction Vaccine discovery
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The incidence and case-fatality rates (CFRs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the etiological agent for Coronavirus Disease 2019 (COVID-19), have been rising unabated. Even though the entire world has been implementing infection prevention and control measures, the pandemic continues to spread. It has been widely accepted that preventive vaccination strategies are the public health measures for countering this pandemic. This study critically reviews the latest scientific advancement in genomics, replication pattern, pathogenesis, and immunopathology of SARS-CoV-2 infection and how these concepts could be used in the development of vaccines. We also offer a detailed discussion on the anticipated potency, efficacy, safety, and pharmaco-economic issues that are and will be associated with candidate COVID-19 vaccines.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	2164-5515 2164-554X
DOI:	10.1080/21645515.2020.1812313