Search Results - "Isom, D G"

DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery by Kapolka, N. J., Taghon, G. J., Rowe, J. B., Morgan, W. M., Enten, J. F., Lambert, N. A., Isom, D. G.

“…More than 800 G protein-coupled receptors (GPCRs) comprise the largest class of membrane receptors in humans. While there is ample biological understanding and…”
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The pK sub(a) Values of Acidic and Basic Residues Buried at the Same Internal Location in a Protein Are Governed by Different Factors by Harms, MJ, Castaneda, CA, Schlessman, J L, Sue, G R, Isom, D G, Cannon, B R, Garcia-Moreno E, B

“…The pK sub(a) values of internal ionizable groups are usually very different from the normal pK sub(a) values of ionizable groups in water. To examine the…”
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Local Secondary Structure Content Predicts Folding Rates for Simple, Two-state Proteins by Gong, Haipeng, Isom, Daniel G, Srinivasan, Rajgopal, Rose, George D

“…Many single-domain proteins exhibit two-state folding kinetics, with folding rates that span more than six orders of magnitude. A quantity of much recent…”
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Hydration of the Folding Transition State Ensemble of a Protein by Brun, Ludovic, Isom, Daniel G, Velu, Priya, García-Moreno, Bertrand, Royer, Catherine Ann

“…A complete description of the mechanisms of protein folding requires knowledge of the structural and physical character of the folding transition state…”
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