Search Results - "Iso, Kentaro"

Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel‐Mediated One‐Pot Ketone Synthesis as the Final Coupling Reaction by Yahata, Kenzo, Ye, Ning, Ai, Yanran, Iso, Kentaro, Kishi, Yoshito

“…Unified, efficient, and scalable syntheses of the halichondrin natural products are reported. A newly developed Zr/Ni‐mediated one‐pot ketone synthesis was…”
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Delivery of a BET protein degrader via a CEACAM6-targeted antibody–drug conjugate inhibits tumour growth in pancreatic cancer models by Nakazawa, Youya, Miyano, Masayuki, Tsukamoto, Shuntaro, Kogai, Hiroyuki, Yamamoto, Akihiko, Iso, Kentaro, Inoue, Satoshi, Yamane, Yoshinobu, Yabe, Yuki, Umihara, Hirotatsu, Taguchi, Junichi, Akagi, Tsuyoshi, Yamaguchi, Atsumi, Koga, Minaho, Toshimitsu, Kohta, Hirayama, Toshifumi, Mukai, Yohei, Machinaga, Akihito

“…Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all cancers. To improve PDAC therapy, we establish screening systems based on organoid and…”
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A Concise Synthesis of the Pentacyclic Framework of Cortistatins by Yamashita, Shuji, Iso, Kentaro, Hirama, Masahiro

“…An efficient synthesis of the pentacyclic framework of cortistatins has been developed. The key strategy comprises assembly of the A- and the CD-ring fragments…”
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A landmark in drug discovery based on complex natural product synthesis by Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Abe, Takanori, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

“…Despite their outstanding antitumour activity in mice, the limited supply from the natural sources has prevented drug discovery/development based on intact…”
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Efficient and stereoselective installation of isoquinoline: formal total synthesis of cortistatin A by Yamashita, Shuji, Kitajima, Kazuki, Iso, Kentaro, Hirama, Masahiro

“…The highly stereoselective attachment of isoquinoline onto the steroidal framework of cortistatin A has been achieved. Our strategy features a Ce-mediated…”
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Synthesis of the Bicyclo[7.3.0]dodecadiyne Core of the Maduropeptin Chromophore by Iso, Kentaro, Inoue, Masayuki, Kato, Nobuki, Hirama, Masahiro

“…Maduropeptin, an extremely potent antitumor agent, consists of a 1:1 complex of a carrier protein and a chromophore. We report herein a general and efficient…”
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A Facile Synthesis of 1,2-Dihydroisoquinolines by Three-Component Reaction by Asao, Naoki, Iso, Kentaro, Yudha S., Salprima, Menggenbateer, _

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Total Synthesis of Cortistatins A and J by Yamashita, Shuji, Iso, Kentaro, Kitajima, Kazuki, Himuro, Masafumi, Hirama, Masahiro

“…This paper describes the details of our synthetic studies on the marine steroidal alkaloids cortistatins A and J. The key features of our strategy include (i)…”
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Targeted protein degradation via intramolecular bivalent glues by Hsia, Oliver, Hinterndorfer, Matthias, Cowan, Angus D., Iso, Kentaro, Ishida, Tasuku, Sundaramoorthy, Ramasubramanian, Nakasone, Mark A., Imrichova, Hana, Schätz, Caroline, Rukavina, Andrea, Husnjak, Koraljka, Wegner, Martin, Correa-Sáez, Alejandro, Craigon, Conner, Casement, Ryan, Maniaci, Chiara, Testa, Andrea, Kaulich, Manuel, Dikic, Ivan, Winter, Georg E., Ciulli, Alessio

“…Targeted protein degradation is a pharmacological modality that is based on the induced proximity of an E3 ubiquitin ligase and a target protein to promote…”
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Stereocontrolled Synthesis of Left Halves of Halichondrins by Yahata, Kenzo, Ye, Ning, Iso, Kentaro, Ai, Yanran, Lee, Jihoon, Kishi, Yoshito

“…A stereocontrolled synthesis of the left halves of halichondrins was reported. An intramolecular oxy-Michael reaction under basic conditions was used to…”
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E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling by Yamada, Kazuhiko, Hori, Yusaku, Inoue, Satoshi, Yamamoto, Yuji, Iso, Kentaro, Kamiyama, Hiroshi, Yamaguchi, Atsumi, Kimura, Takayuki, Uesugi, Mai, Ito, Junichi, Matsuki, Masahiro, Nakamoto, Kazutaka, Harada, Hitoshi, Yoneda, Naoki, Takemura, Atsushi, Kushida, Ikuo, Wakayama, Naomi, Kubara, Kenji, Kato, Yu, Semba, Taro, Yokoi, Akira, Matsukura, Masayuki, Odagami, Takenao, Iwata, Masao, Tsuruoka, Akihiko, Uenaka, Toshimitsu, Matsui, Junji, Matsushima, Tomohiro, Nomoto, Kenichi, Kouji, Hiroyuki, Owa, Takashi, Funahashi, Yasuhiro, Ozawa, Yoichi

“…The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and the development of multiple types of cancer, and its aberrant activation…”
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Unified Synthesis of Right Halves of Halichondrins A–C by Yahata, Kenzo, Ye, Ning, Iso, Kentaro, Naini, Santhosh Reddy, Yamashita, Shuji, Ai, Yanran, Kishi, Yoshito

“…The right halves of halichondrins A–C were synthesized by coupling the common C20–C37 building block 9 with the C1–C19 building blocks 10a–c, respectively…”
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Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials by Kaburagi, Yosuke, Kira, Kazunobu, Yahata, Kenzo, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Matsuda, Masaaki, Matsukura, Masayuki, Murai, Norio, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Watanabe, Yuzo, Kamada, Atsushi, Kayano, Akio, Tagami, Katsuya, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

“…E7130 is a novel drug candidate with an exceedingly complex chemical structure of the halichondrin class, discovered by a total synthesis approach through…”
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What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical Study by Sasaki, Takeo, Yahata, Kenzo, Isomura, Minetaka, Ohashi, Isao, Fukuyama, Takashi, Miyashita, Yusuke, Watanabe, Yuzo, Murai, Norio, Matsuda, Masaaki, Kamada, Atsushi, Kaburagi, Yosuke, Kira, Kazunobu, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Matsumoto, Yasunobu, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Matsukura, Masayuki, Asano, Osamu, Kayano, Akio, Tagami, Katsuya, Owa, Takashi, Kishi, Yoshito

“…Process development of E7130 Drug Substance, which is a novel anticancer drug candidate, is described. To accomplish rapid delivery of such a large and…”
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An Environmentally Friendly Synthetic Method of 1,2-Dihydroisoquinoline Frameworks via Three-Component Reaction with o-Alkynylbenzaldehydes, Primary Amines, and Pronucleophiles by Asao, Naoki, Iso, Kentaro, Yudha S, Salprima

“…Three-component reactions with ortho-alkynylbenzaldehydes, primary amines, and pronucleophiles (Nu-H), such as CHCl3, proceeded to give 1,2-dihydroisoquinoline…”
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Abstract 4179: E7130 derived from total synthesis of halichondrin as a novel tumor-microenvironment ameliorator by Kawano, Satoshi, Abe, Takanori, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

“…Abstract Background and objectives: Natural products have been a rich source of inspiration for drug discovery as demonstrated by the fact that over one-third…”
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Abstract 4183: Mechanism of action analysis of anti-CAF activity of E7130, a novel tumor-microenvironment ameliorator by Abe, Takanori, Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

“…Abstract Background and objectives: Despite the outstanding antitumor activity of halichondrins in mice, the limited supply from the natural sources has…”
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Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel‐Mediated One‐Pot Ketone Synthesis as the Final Coupling Reaction by Yahata, Kenzo, Ye, Ning, Ai, Yanran, Iso, Kentaro, Kishi, Yoshito

“…Unified, efficient, and scalable syntheses of the halichondrin natural products are reported. A newly developed Zr/Ni‐mediated one‐pot ketone synthesis was…”
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Abstract 5177: E7386 : First-in-class orally active CBP/beta-catenin modulator as an anticancer agent by Yamada, Kazuhiko, Hori, Yusaku, Yamaguchi, Atsumi, Matsuki, Masahiro, Tsukamoto, Shuntaro, Yokoi, Akira, Semba, Taro, Ozawa, Yoichi, Inoue, Satoshi, Yamamoto, Yuji, Iso, Kentaro, Nakamoto, Kazutaka, Harada, Hitoshi, Yoneda, Naoki, Takemura, Atsushi, Matsukura, Masayuki, Kubara, Kenji, Odagami, Takenao, Iwata, Masao, Tsuruoka, Akihiko, Uenaka, Toshimitsu, Matsui, Junji, Matsushima, Tomohiro, Nomoto, Kenich, Kouji, Hiroyuki, Owa, Takashi

“…Abstract Carcinogenesis is often accelerated by the aberrant activation of components molecules of Wnt signaling pathway, especially, APC and beta-catenin are…”
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