Search Results - "Ismail, Nevien"

Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity by Bhattacharya, Parna, Ismail, Nevien, Saxena, Ankit, Gannavaram, Sreenivas, Dey, Ranadhir, Oljuskin, Timur, Akue, Adovi, Takeda, Kazuyo, Yu, James, Karmakar, Subir, Dagur, Pradeep K, McCoy, Jr, John Philip, Nakhasi, Hira L

“…Neutrophils are involved in the initial host responses to pathogens. Neutrophils can activate T cell responses either independently or through indirect…”
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Live Attenuated Leishmania donovani Centrin Gene-Deleted Parasites Induce IL-23-Dependent IL-17-Protective Immune Response against Visceral Leishmaniasis in a Murine Model by Banerjee, Antara, Bhattacharya, Parna, Dagur, Pradeep K, Karmakar, Subir, Ismail, Nevien, Joshi, Amritanshu B, Akue, Adovi D, KuKuruga, Mark, McCoy, Jr, John Philip, Dey, Ranadhir, Nakhasi, Hira L

“…No vaccine exists against visceral leishmaniasis. To develop effective vaccines, we have previously reported protective role of live attenuated centrin…”
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Deletion of MIF gene from live attenuated LdCen−/− parasites enhances protective CD4+ T cell immunity by Fiuza, Jacqueline Araújo, Gannavaram, Sreenivas, Gaze, Soraya Torres, de Ornellas, Letícia Gambogi, Alves, Érica Alessandra, Ismail, Nevien, Nakhasi, Hira Lal, Correa-Oliveira, Rodrigo

“…Vaccination with live attenuated Leishmania parasites such as centrin deleted Leishmania donovani ( LdCen −/− ) against visceral leishmaniasis has been…”
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Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis by Karmakar, Subir, Ismail, Nevien, Oliveira, Fabiano, Oristian, James, Zhang, Wen Wei, Kaviraj, Swarnendu, Singh, Kamaleshwar P., Mondal, Abhishek, Das, Sushmita, Pandey, Krishna, Bhattacharya, Parna, Volpedo, Greta, Gannavaram, Sreenivas, Satoskar, Monika, Satoskar, Sanika, Sastry, Rajiv M., Oljuskin, Timur, Sepahpour, Telly, Meneses, Claudio, Hamano, Shinjiro, Das, Pradeep, Matlashewski, Greg, Singh, Sanjay, Kamhawi, Shaden, Dey, Ranadhir, Valenzuela, Jesus G., Satoskar, Abhay, Nakhasi, Hira L.

“…Visceral Leishmaniasis (VL), a potentially fatal disease is caused by Leishmania donovani parasites with no vaccine available. Here we produced a dermotropic…”
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miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen -/- Immunization by Gannavaram, Sreenivas, Bhattacharya, Parna, Siddiqui, Abid, Ismail, Nevien, Madhavan, Subha, Nakhasi, Hira L

“…No vaccine exists against visceral leishmaniasis. Toward developing vaccines against VL, we have reported previously on the immunogenicity of live attenuated…”
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Immunization with Live Attenuated Leishmania donovani Centrin -/- Parasites Is Efficacious in Asymptomatic Infection by Ismail, Nevien, Kaul, Amit, Bhattacharya, Parna, Gannavaram, Sreenivas, Nakhasi, Hira L

“…Currently, there is no vaccine against visceral leishmaniasis (VL). Toward developing an effective vaccine, we have reported extensively on the immunogenicity…”
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Leishmania Major Centrin Gene-Deleted Parasites Generate Skin Resident Memory T-Cell Immune Response Analogous to Leishmanization by Ismail, Nevien, Karmakar, Subir, Bhattacharya, Parna, Sepahpour, Telly, Takeda, Kazuyo, Hamano, Shinjiro, Matlashewski, Greg, Satoskar, Abhay R, Gannavaram, Sreenivas, Dey, Ranadhir, Nakhasi, Hira L

“…Leishmaniasis is a vector-borne parasitic disease transmitted through the bite of a sand fly with no available vaccine for humans. Recently, we have developed…”
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Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization by Gannavaram, Sreenivas, Torcivia, John, Gasparyan, Lusine, Kaul, Amit, Ismail, Nevien, Simonyan, Vahan, Nakhasi, Hira L.

“…No licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including…”
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Centrin-Deleted Leishmania donovani Parasites Help CD4 + T Cells to Acquire Th1 Phenotype and Multi-Functionality Through Downregulation of CD200-CD200R Immune Inhibitory Axis by Singh, Rakesh K, Gannavaram, Sreenivas, Ismail, Nevien, Kaul, Amit, Gedda, Mallikarjuna Rao, Nakhasi, Hira L

“…The protozoan parasite has evolved several strategies to undermine host defense mechanisms by inducing Th2-type adaptive immunity and suppressing effector…”
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Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis by Bhattacharya, Parna, Dey, Ranadhir, Dagur, Pradeep K, Joshi, Amritanshu B, Ismail, Nevien, Gannavaram, Sreenivas, Debrabant, Alain, Akue, Adovi D, KuKuruga, Mark A, Selvapandiyan, Angamuthu, McCoy, Jr, John Philip, Nakhasi, Hira L

“…Visceral leishmaniasis (VL) caused by the protozoan parasite Leishmania donovani causes severe disease. Age appears to be critical in determining the clinical…”
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Toll-like Receptor-9 (TLR-9) Signaling Is Crucial for Inducing Protective Immunity following Immunization with Genetically Modified Live Attenuated Leishmania Parasites by Bhattacharya, Parna, Gannavaram, Sreenivas, Ismail, Nevien, Saxena, Ankit, Dagur, Pradeep K, Akue, Adovi, KuKuruga, Mark, Nakhasi, Hira L

“…No human vaccine is available for visceral leishmaniasis (VL). Live attenuated centrin gene-deleted ( ) parasite vaccine has been shown to induce robust innate…”
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Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis by Karmakar, Subir, Volpedo, Greta, Zhang, Wen-Wei, Lypaczewski, Patrick, Ismail, Nevien, Oliveira, Fabiano, Oristian, James, Meneses, Claudio, Gannavaram, Sreenivas, Kamhawi, Shaden, Hamano, Shinjiro, Valenzuela, Jesus G., Matlashewski, Greg, Satoskar, Abhay R., Dey, Ranadhir, Nakhasi, Hira L.

“…Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). However, this…”
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Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β by Dey, Ranadhir, Joshi, Amritanshu B., Oliveira, Fabiano, Pereira, Lais, Guimarães-Costa, Anderson B., Serafim, Tiago D., de Castro, Waldionê, Coutinho-Abreu, Iliano V., Bhattacharya, Parna, Townsend, Shannon, Aslan, Hamide, Perkins, Alec, Karmakar, Subir, Ismail, Nevien, Karetnick, Morgan, Meneses, Claudio, Duncan, Robert, Nakhasi, Hira L., Valenzuela, Jesus G., Kamhawi, Shaden

“…Leishmania donovani parasites are the cause of visceral leishmaniasis and are transmitted by bites from phlebotomine sand flies. A prominent feature of…”
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Role of pro-inflammatory cytokine IL-17 in Leishmania pathogenesis and in protective immunity by Leishmania vaccines by Banerjee, Antara, Bhattacharya, Parna, Joshi, Amritanshu B., Ismail, Nevien, Dey, Ranadhir, Nakhasi, Hira L.

“…•IL-17 is pro-inflammatory in nature and kills intracellular pathogens.•According to published studies, the role of IL-17 is contradictory in…”
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Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules by Gannavaram, Sreenivas, Bhattacharya, Parna, Ismail, Nevien, Kaul, Amit, Singh, Rakesh, Nakhasi, Hira L

“…No licensed human vaccines are currently available against any parasitic disease including leishmaniasis. Several antileishmanial vaccine formulations have…”
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A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing by Zhang, Wen-Wei, Karmakar, Subir, Gannavaram, Sreenivas, Dey, Ranadhir, Lypaczewski, Patrick, Ismail, Nevien, Siddiqui, Abid, Simonyan, Vahan, Oliveira, Fabiano, Coutinho-Abreu, Iliano V., DeSouza-Vieira, Thiago, Meneses, Claudio, Oristian, James, Serafim, Tiago D., Musa, Abu, Nakamura, Risa, Saljoughian, Noushin, Volpedo, Greta, Satoskar, Monika, Satoskar, Sanika, Dagur, Pradeep K., McCoy, J. Philip, Kamhawi, Shaden, Valenzuela, Jesus G., Hamano, Shinjiro, Satoskar, Abhay R., Matlashewski, Greg, Nakhasi, Hira L.

“…Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live…”
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Immunization with Leishmania major centrin knock-out ( LmCen −/− ) parasites induces skin resident memory T cells that plays a role in protection against wild type infection ( LmWT ) by Ismail, Nevien, Karmakar, Subir, Bhattacharya, Parna, Dey, Ranadhir, Nakhasi, Hira L

“…Abstract Leishmaniasis is a vector-born disease transmitted through sand fly bite with no available vaccine. Vaccination through leishmanization with…”
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Essential Role of Neutrophils in the Protective Immune Response Induced by a Live Attenuated Leishmania Vaccine by Bhattacharya, Parna, Dey, Ranadhir, Saxena, Ankit, Karmakar, Subir, Ismail, Nevien, Gannavaram, Sreenivas, Dagur, Pradeep K, Satoskar, Monika, Satoskar, Sanika, De Paoli, Silvia, Takeda, Kazuyo, McCoy, Jr, John Philip, Nakhasi, Hira L

“…No licensed vaccine exists against visceral leishmaniasis (VL), a disease caused by the parasite. We have previously reported both macrophages and dendritic…”
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Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice by Bhattacharya, Parna, Dey, Ranadhir, Dagur, Pradeep K, Kruhlak, Michael, Ismail, Nevien, Debrabant, Alain, Joshi, Amritanshu B, Akue, Adovi, Kukuruga, Mark, Takeda, Kazuyo, Selvapandiyan, Angamuthu, McCoy, Jr, John Philip, Nakhasi, Hira L

“…Visceral leishmaniasis (VL) causes significant mortality and there is no effective vaccine. Previously, we have shown that genetically modified Leishmania…”
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Identification of microRNA-21 as a biomarker in live attenuated Leishmania vaccine induced protective immunity by Bhattacharya, Parna, Ismail, Nevien, Kaul, Amit, Gannavaram, Sreenivas, Nakhasi, Hira L

“…Abstract No vaccine exists against visceral leishmaniasis. Towards developing an effective vaccine, we have reported extensively on the immunogenicity of live…”
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