Search Results - "Ismail, Nasreen"

Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection by Kazer, Samuel W., Aicher, Toby P., Muema, Daniel M., Carroll, Shaina L., Ordovas-Montanes, Jose, Miao, Vincent N., Tu, Ang A., Ziegler, Carly G. K., Nyquist, Sarah K., Wong, Emily B., Ismail, Nasreen, Dong, Mary, Moodley, Amber, Berger, Bonnie, Love, J. Christopher, Dong, Krista L., Leslie, Alasdair, Ndhlovu, Zaza M., Ndung’u, Thumbi, Walker, Bruce D., Shalek, Alex K.

“…Cellular immunity is critical for controlling intracellular pathogens, but individual cellular dynamics and cell–cell cooperativity in evolving human immune…”
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CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection by Baiyegunhi, Omolara O., Mann, Jaclyn, Khaba, Trevor, Nkosi, Thandeka, Mbatha, Anele, Ogunshola, Funsho, Chasara, Caroline, Ismail, Nasreen, Ngubane, Thandekile, Jajbhay, Ismail, Pansegrouw, Johan, Dong, Krista L., Walker, Bruce D., Ndung’u, Thumbi, Ndhlovu, Zaza M.

“…HIV persistence in tissue sites despite ART is a major barrier to HIV cure. Detailed studies of HIV-infected cells and immune responses in native lymph node…”
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Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection by Muema, Daniel M, Akilimali, Ngomu A, Ndumnego, Okechukwu C, Rasehlo, Sipho S, Durgiah, Raveshni, Ojwach, Doty B A, Ismail, Nasreen, Dong, Mary, Moodley, Amber, Dong, Krista L, Ndhlovu, Zaza M, Mabuka, Jenniffer M, Walker, Bruce D, Mann, Jaclyn K, Ndung'u, Thumbi

“…Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced immunological…”
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Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study by Byrne, Elizabeth H, MSc, Anahtar, Melis N, PhD, Cohen, Kathleen E, MD, Moodley, Amber, MPH, Padavattan, Nikita, BSc, Ismail, Nasreen, MSc, Bowman, Brittany A, BSc, Olson, Gregory S, BA, Mabhula, Amanda, BSc, Leslie, Alasdair, PhD, Ndung'u, Thumbi, PhD, Walker, Bruce D, Prof, Ghebremichael, Musie S, PhD, Dong, Krista L, MD, Kwon, Douglas S, Dr

“…Summary Background The use of injectable progestin-only contraceptives has been associated with increased risk of HIV acquisition in observational studies, but…”
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Antigen Presenting Cells Contribute to Persistent Immune Activation Despite Antiretroviral Therapy Initiation During Hyperacute HIV-1 Infection by Naidoo, Kewreshini K, Ndumnego, Okechukwu C, Ismail, Nasreen, Dong, Krista L, Ndung'u, Thumbi

“…Human immunodeficiency virus (HIV)-induced changes in immune cells during the acute phase of infection can cause irreversible immunological damage and predict…”
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The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans by Naidoo, Kewreshini K, Shangase, Zesuliwe B, Rashid, Tabassum, Ngubane, Ayanda, Ismail, Nasreen, Ndung'u, Thumbi, Thobakgale, Christina F

“…The Duffy Antigen Receptor for Chemokines (DARC)-null trait, common among persons of African descent and associated with lower absolute neutrophil counts…”
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Dual HLA B42 and B81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants by Ogunshola, Funsho, Anmole, Gursev, Miller, Rachel L., Goering, Emily, Nkosi, Thandeka, Muema, Daniel, Mann, Jaclyn, Ismail, Nasreen, Chopera, Denis, Ndung’u, Thumbi, Brockman, Mark A., Ndhlovu, Zaza M

“…Some closely related human leukocyte antigen (HLA) alleles are associated with variable clinical outcomes following HIV-1 infection despite presenting the same…”
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Modeling the temporal dynamics of cervicovaginal microbiota identifies targets that may promote reproductive health by Munoz, Alexander, Hayward, Matthew R., Bloom, Seth M., Rocafort, Muntsa, Ngcapu, Sinaye, Mafunda, Nomfuneko A., Xu, Jiawu, Xulu, Nondumiso, Dong, Mary, Dong, Krista L., Ismail, Nasreen, Ndung’u, Thumbi, Ghebremichael, Musie S., Kwon, Douglas S.

“…Abstract Background Cervicovaginal bacterial communities composed of diverse anaerobes with low Lactobacillus abundance are associated with poor reproductive…”
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Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation by Bloom, Seth M., Mafunda, Nomfuneko A., Woolston, Benjamin M., Hayward, Matthew R., Frempong, Josephine F., Abai, Aaron B., Xu, Jiawu, Mitchell, Alissa J., Westergaard, Xavier, Hussain, Fatima A., Xulu, Nondumiso, Dong, Mary, Dong, Krista L., Gumbi, Thandeka, Ceasar, F. Xolisile, Rice, Justin K., Choksi, Namit, Ismail, Nasreen, Ndung’u, Thumbi, Ghebremichael, Musie S., Relman, David A., Balskus, Emily P., Mitchell, Caroline M., Kwon, Douglas S.

“…Vaginal microbiota composition affects many facets of reproductive health. Lactobacillus iners -dominated microbial communities are associated with poorer…”
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Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies by Mabuka, Jenniffer M, Dugast, Anne-Sophie, Muema, Daniel M, Reddy, Tarylee, Ramlakhan, Yathisha, Euler, Zelda, Ismail, Nasreen, Moodley, Amber, Dong, Krista L, Morris, Lynn, Walker, Bruce D, Alter, Galit, Ndung'u, Thumbi

“…Immunological events in acute HIV-1 infection before peak viremia (hyperacute phase) may contribute to the development of broadly cross-neutralizing…”
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Antigen Presenting Cells Link the Female Genital Tract Microbiome to Mucosal Inflammation, With Hormonal Contraception as an Additional Modulator of Inflammatory Signatures by Byrne, Elizabeth H., Farcasanu, Mara, Bloom, Seth M., Xulu, Nondumiso, Xu, Jiawu, Hykes, Barry L., Mafunda, Nomfuneko A., Hayward, Matthew R., Dong, Mary, Dong, Krista L., Gumbi, Thandeka, Ceasar, Fransisca Xolisile, Ismail, Nasreen, Ndung’u, Thumbi, Gosmann, Christina, Ghebremichael, Musie S., Handley, Scott A., Mitchell, Caroline M., Villani, Alexandra-Chloé, Kwon, Douglas S.

“…The microbiome of the female genital tract (FGT) is closely linked to reproductive health outcomes. Diverse, anaerobe-dominated communities with low…”
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HIGH-FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal needs causing maternal NON-ADHERENCE by Millar, Jane R., Bengu, Nomonde, Fillis, Rowena, Sprenger, Ken, Ntlantsana, Vuyokazi, Vieira, Vinicius A., Khambati, Nisreen, Archary, Moherndran, Muenchhoff, Maximilian, Groll, Andreas, Grayson, Nicholas, Adamson, John, Govender, Katya, Dong, Krista, Kiepiela, Photini, Walker, Bruce D., Bonsall, David, Connor, Thomas, Bull, Matthew J., Nxele, Nelisiwe, Roider, Julia, Ismail, Nasreen, Adland, Emily, Puertas, Maria C., Martinez-Picado, Javier, Matthews, Philippa C., Ndung'u, Thumbi, Goulder, Philip

“…Early combination antiretroviral therapy (cART) reduces the size of the viral reservoir in paediatric and adult HIV infection. Very early-treated children may…”
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Correction to: Modeling the temporal dynamics of cervicovaginal microbiota identifies targets that may promote reproductive health by Munoz, Alexander, Hayward, Matthew R, Bloom, Seth M, Rocafort, Muntsa, Ngcapu, Sinaye, Mafunda, Nomfuneko A, Xu, Jiawu, Xulu, Nondumiso, Dong, Mary, Dong, Krista L, Ismail, Nasreen, Ndung'u, Thumbi, Ghebremichael, Musie S, Kwon, Douglas S

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HIV Control through a Single Nucleotide on the HLA-B Locus by Kløverpris, Henrik N, Harndahl, Mikkel, Leslie, Alasdair J, Carlson, Jonathan M, Ismail, Nasreen, van der Stok, Mary, Huang, Kuan-Hsiang Gary, Chen, Fabian, Riddell, Lynn, Steyn, Dewald, Goedhals, Dominique, van Vuuren, Cloete, Frater, John, Walker, Bruce D, Carrington, Mary, Ndung'u, Thumbi, Buus, Søren, Goulder, Philip

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Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection by DAY, Cheryl L, KIEPIELA, Photini, WALKER, Bruce D, KLENERMAN, Paul, LESLIE, Alasdair J, VAN DER STOK, Mary, NAIR, Kriebashne, ISMAIL, Nasreen, HONEYBORNE, Isobella, CRAWFORD, Hayley, COOVADIA, Hoosen M, GOULDER, Philip J. R

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Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women by Gosmann, Christina, Anahtar, Melis N., Handley, Scott A., Farcasanu, Mara, Abu-Ali, Galeb, Bowman, Brittany A., Padavattan, Nikita, Desai, Chandni, Droit, Lindsay, Moodley, Amber, Dong, Mary, Chen, Yuezhou, Ismail, Nasreen, Ndung’u, Thumbi, Ghebremichael, Musie S., Wesemann, Duane R., Mitchell, Caroline, Dong, Krista L., Huttenhower, Curtis, Walker, Bruce D., Virgin, Herbert W., Kwon, Douglas S.

“…Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their…”
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Cervicovaginal Bacteria Are a Major Modulator of Host Inflammatory Responses in the Female Genital Tract by Anahtar, Melis N., Byrne, Elizabeth H., Doherty, Kathleen E., Bowman, Brittany A., Yamamoto, Hidemi S., Soumillon, Magali, Padavattan, Nikita, Ismail, Nasreen, Moodley, Amber, Sabatini, Mary E., Ghebremichael, Musie S., Nusbaum, Chad, Huttenhower, Curtis, Virgin, Herbert W., Ndung’u, Thumbi, Dong, Krista L., Walker, Bruce D., Fichorova, Raina N., Kwon, Douglas S.

“…Colonization by Lactobacillus in the female genital tract is thought to be critical for maintaining genital health. However, little is known about how genital…”
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Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load by Baiyegunhi, Omolara, Ndlovu, Bongiwe, Ogunshola, Funsho, Ismail, Nasreen, Walker, Bruce D, Ndung'u, Thumbi, Ndhlovu, Zaza M

“…Despite decades of focused research, the field has yet to develop a prophylactic vaccine for HIV-1 infection. In the RV144 vaccine trial, nonneutralizing…”
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Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point by Ndhlovu, Zaza M., Kamya, Philomena, Mewalal, Nikoshia, Kløverpris, Henrik N., Nkosi, Thandeka, Pretorius, Karyn, Laher, Faatima, Ogunshola, Funsho, Chopera, Denis, Shekhar, Karthik, Ghebremichael, Musie, Ismail, Nasreen, Moodley, Amber, Malik, Amna, Leslie, Alasdair, Goulder, Philip J.R., Buus, Søren, Chakraborty, Arup, Dong, Krista, Ndung’u, Thumbi, Walker, Bruce D.

“…CD8+ T cells contribute to the control of HIV, but it is not clear whether initial immune responses modulate the viral set point. We screened high-risk…”
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Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound by Millar, Jane R, Bengu, Nomonde, Vieira, Vinicius A, Adland, Emily, Roider, Julia, Muenchhoff, Maximilian, Fillis, Rowena, Sprenger, Kenneth, Ntlantsana, Vuyokazi, Fatti, Isabella, Archary, Moherndran, Groll, Andreas, Ismail, Nasreen, García-Guerrero, Maria C, Matthews, Philippa C, Ndung’u, Thumbi, Puertas, Maria C, Martinez-Picado, Javier, Goulder, Philip

“…Abstract Background Early HIV diagnosis allows combination antiretroviral therapy (cART) initiation in the first days of life following in utero (IU)…”
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