Search Results - "Ismail, Jiffry"

Lead Optimization toward Proof-of-Concept Tools for Huntington’s Disease within a 4‑(1H‑Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors by Wityak, John, McGee, Kevin F, Conlon, Michael P, Song, Ren Hua, Duffy, Bryan C, Clayton, Brent, Lynch, Michael, Wang, Gwen, Freeman, Emily, Haber, James, Kitchen, Douglas B, Manning, David D, Ismail, Jiffry, Khmelnitsky, Yuri, Michels, Peter, Webster, Jeff, Irigoyen, Macarena, Luche, Michele, Hultman, Monica, Bai, Mei, Kuok, IokTeng D, Newell, Ryan, Lamers, Marieke, Leonard, Philip, Yates, Dawn, Matthews, Kim, Ongeri, Lynette, Clifton, Steve, Mead, Tania, Deupree, Susan, Wheelan, Pat, Lyons, Kathy, Wilson, Claire, Kiselyov, Alex, Toledo-Sherman, Leticia, Beconi, Maria, Muñoz-Sanjuan, Ignacio, Bard, Jonathan, Dominguez, Celia

“…Through medicinal chemistry lead optimization studies focused on calculated properties and guided by X-ray crystallography and computational modeling, potent…”
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Synthesis and Biological Evaluation of N‑((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter‑1 by Cioffi, Christopher L, Liu, Shuang, Wolf, Mark A, Guzzo, Peter R, Sadalapure, Kashinath, Parthasarathy, Visweswaran, Loong, David T. J, Maeng, Jun-Ho, Carulli, Edmund, Fang, Xiao, Karunakaran, Kalesh, Matta, Lakshman, Choo, Sok Hui, Panduga, Shailijia, Buckle, Ronald N, Davis, Randall N, Sakwa, Samuel A, Gupta, Priya, Sargent, Bruce J, Moore, Nicholas A, Luche, Michele M, Carr, Grant J, Khmelnitsky, Yuri L, Ismail, Jiffry, Chung, Mark, Bai, Mei, Leong, Wei Yee, Sachdev, Nidhi, Swaminathan, Srividya, Mhyre, Andrew J

“…We previously disclosed the discovery of rationally designed N-((1-(4-(propylsulfonyl)­piperazin-1-yl)­cycloalkyl)­methyl)­benzamide inhibitors of glycine…”
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