Search Results - "Ismaiel, Abd M."

Ketanserin Analogs: The Effect of Structural Modification on 5-HT2 Serotonin Receptor Binding by Ismaiel, Abd M, Arruda, Kim, Teitler, Milt, Glennon, Richard A

“…Ketanserin (1) is a fairly selective 5-HT2 antagonist that binds both at 5-HT2A and 5-HT2C receptors. A previous structure-affinity relationship study revealed…”
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5-HT1 and 5-HT2 binding profiles of the serotonergic agents .alpha.-methylserotonin and 2-methylserotonin by Ismaiel, Abd M, Titeler, Milt, Miller, Keith J, Smith, Thomas S, Glennon, Richard A

“…alpha-Methyl-5-hydroxytryptamine (alpha-Me-5-HT; 2) and 2-methyl-5-hydroxytryptamine (2-Me-5-HT; 3) are considered to be 5-HT2-selective and 5-HT3-selective…”
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Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists by Glennon, Richard A, Metwally, Kamel, Dukat, Malgorzata, Ismaiel, Abd M, De los Angeles, Joseph, Herndon, Jeffery, Teitler, Milt, Khorana, Nantaka

“…The structures of ketanserin (1) and spiperone (2) were examined in detail to determine the role of various substituent groups on 5-HT(2A) receptor affinity…”
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Thioxanthene-derived analogs as σ1 receptor ligands by GLENNON, Richard A, ISMAIEL, Abd M, ABLORDEPPEY, Seth, EL-ASHMAWY, Mahmoud, FISHER, James B

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Structure−Activity Relationships for the Binding of Arylpiperazines and Arylbiguanides at 5-HT3 Serotonin Receptors by Dukat, Małgorzata, Abdel-Rahman, Ashraf A, Ismaiel, Abd M, Ingher, Stacy, Teitler, Milt, Gyermek, Laszlo, Glennon, Richard A

“…Arylpiperazines are nonselective agents that bind at 5-HT3 serotonin receptors with moderate to high affinity, whereas 1-phenylbiguanide is a low-affinity but…”
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Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist by Ismaiel, Abd M, De Los Angeles, Joseph, Teitler, Milt, Ingher, Stacy, Glennon, Richard A

“…DOM [i.e., 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane] is a 5-HT1C/2 serotonin agonist that exerts stimulus control of behavior in animals. In order to…”
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2-(1-Naphthyloxy)ethylamines with Enhanced Affinity for Human 5-HT1D β (h5-HT1B) Serotonin Receptors by Ismaiel, Abd M, Dukat, Malgorzata, Law, Ho, Kamboj, Rajender, Fan, Ermi, Lee, David K. H, Mazzocco, Lucia, Buekschkens, Donna, Teitler, Milt, Pierson, Myles E, Glennon, Richard A

“…Although the β-adrenergic antagonist propranolol (1) binds at rodent 5-HT1B serotonin receptors, it displays low affinity (K i > 10 000 nM) for its species…”
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Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity .sigma. ligands by Glennon, Richard A, Yousif, Mamoun Y, Ismaiel, Abd M, El-Ashmawy, Mahmoud B, Herndon, J. L, Fischer, James B, Server, Alfred C, Howie, Kathleen J. Burke

“…sigma receptors may represent an exciting new approach for the development of novel psychotherapeutic agents. Unfortunately, many of the commonly used sigma…”
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N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites? by Glennon, Richard A, Naiman, Noreen A, Pierson, M. Edward, Smith, J. Doyle, Ismaiel, Abd M, Titeler, Milt, Lyon, Robert A

“…Several classes of agents are known to bind at central 5-HT1A serotonin sites In order to challenge the hypothesis that these agents bind in a relatively…”
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Identification and exploitation of the .sigma.-opiate pharmacophore by Glennon, Richard A, Smith, J. Doyle, Ismaiel, Abd M, El-Ashmawy, Mahmoud, Battaglia, George, Fischer, James B

“…Certain benzomorphan "sigma-opiates" such as N-allylnormetazocine (NANM) bind at sigma receptors with modest affinity and with little selectivity (i.e., they…”
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Structural Features Important for .sigma.1 Receptor Binding by Glennon, Richard A, Ablordeppey, Seth Y, Ismaiel, Abd M, El-Ashmawy, Mahmoud B, Fischer, James B, Howie, Kathleen Burke

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Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at .sigma.-receptors by Glennon, Richard A, Ismaiel, Abd M, Smith, J. Doyle, Yousif, Mamoun, El-Ashmawy, Mahmoud, Herndon, J. L, Fischer, James B, Howie, Kathleen J. Burke, Server, Alfred C

“…Certain benzomorphans, such as N-allylnormetazocine, are classical "sigma-opiates" that bind both at sigma and phencyclidine (PCP) binding sites with modest…”
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Structural features important for σ1 receptor binding by GLENNON, R. A, ABLORDEPPEY, S. Y, ISMAIEL, A. M, EL-ASHMAWY, M. B, FISCHER, J. B, HOWIE, K. B

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Thioxanthene-derived analogs as σ 1 receptor ligands by Glennon, Richard A, Ismaiel, Abd M, Ablordeppey, Seth, El-Ashmawy, Mahmoud, Fisher, James B

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Thioxanthene-derived analogs as sigma(1) receptor ligands by Glennon, Richard A, Ismaiel, Abd M, Ablordeppey, Seth, El-Ashmawy, Mahmoud, Fisher, James B

“…An investigation of the structure-affinity relationships for the binding of thioxanthene-related structures indicates that an intact thioxanthene ring is not…”
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Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study by Glennon, R A, Ismaiel, A E, McCarthy, B G, Peroutka, S J

“…The binding affinities of a series of arylpiperazine derivatives at [3H]quipazine-labeled central 5-HT3 sites were investigated. Features determined to be…”
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The binding of propranolol at 5-hydroxytryptamine1D beta T355N mutant receptors may involve formation of two hydrogen bonds to asparagine by Glennon, R A, Dukat, M, Westkaemper, R B, Ismaiel, A M, Izzarelli, D G, Parker, E M

“…Although the beta-adrenergic receptor antagonist (-)-propranolol binds with relatively low affinity at human 5-hydroxytryptamine1D beta receptors (Ki = 10,200…”
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NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors by Rydelek-Fitzgerald, L, Teitler, M, Fletcher, P W, Ismaiel, A M, Glennon, R A

“…NAN-190 has been reported to be a 5-HT1A antagonist in drug discrimination studies. In order to determine if the effect of NAN-190 was directly due to…”
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2-(1-Naphthyloxy)ethylamines with Enhanced Affinity for Human 5-HT 1D β (h5-HT 1B ) Serotonin Receptors by Ismaiel, Abd M., Dukat, Malgorzata, Law, Ho, Kamboj, Rajender, Fan, Ermi, Lee, David K. H., Mazzocco, Lucia, Buekschkens, Donna, Teitler, Milt, Pierson, Myles E., Glennon, Richard A.

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Structure−Activity Relationships for the Binding of Arylpiperazines and Arylbiguanides at 5-HT 3 Serotonin Receptors by Dukat, Małgorzata, Abdel-Rahman, Ashraf A., Ismaiel, Abd M., Ingher, Stacy, Teitler, Milt, Gyermek, Laszlo, Glennon, Richard A.

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