Search Results - "Islander, U"

Interleukin 17A: a Janus-faced regulator of osteoporosis by Scheffler, J. M., Grahnemo, L., Engdahl, C., Drevinge, C., Gustafsson, K. L., Corciulo, C., Lawenius, L., Iwakura, Y., Sjögren, K., Lagerquist, M. K., Carlsten, H., Ohlsson, C., Islander, U.

“…Interleukin (IL)-17A is a well-described mediator of bone resorption in inflammatory diseases, and postmenopausal osteoporosis is associated with increased…”
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Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone mice by Drevinge, C, Scheffler, J M, Nordqvist, J, Engdahl, C, Carlsten, H, Islander, U

“…Systemic lupus erythematosus (SLE or lupus) is an autoimmune disease characterized by B-cell dysfunction, production of autoantibodies, and immune complex…”
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Roles of transactivating functions 1 and 2 of estrogen receptor-α in bone by Börjesson, A. E., Windahl, S. H., Lagerquist, M. K., Engdahl, C., Frenkel, B., Movérare-Skrtic, S., Sjögren, K., Kindblom, J. M., Stubelius, A., Islander, U., Antal, M. C., Krust, A., Chambon, P., Ohlsson, C., Gustafsson, Jan-Åke

“…The bone-sparing effect of estrogen is primarily mediated via estrogen receptor-α (ERα), which stimulates target gene transcription through two activation…”
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Osteoporosis in a murine model of postmenopausal lupus by Nordqvist, J, Lagerquist, M K, Grahnemo, L, Koskela, A, Islander, U, Carlsten, H

“…Background/objective Postmenopausal women with systemic lupus erythematosus have an increased risk of osteoporosis and associated fractures. Their increased…”
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ERα expression in T lymphocytes is dispensable for estrogenic effects in bone by Gustafsson, K L, Nilsson, K H, Farman, H H, Andersson, A, Lionikaite, V, Henning, P, Wu, J, Windahl, S H, Islander, U, Movérare-Skrtic, S, Sjögren, K, Carlsten, H, Gustafsson, J-Å, Ohlsson, C, Lagerquist, M K

“…Estrogen treatment has positive effects on the skeleton, and we have shown that estrogen receptor alpha (ERα) expression in cells of hematopoietic origin…”
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Estrogen receptor alpha expression in cartilage is important for the ameliorating effects of estrogen on synovitis, but not joint destruction by Lagerquist, M.K, Engdahl, C, Börjesson, A.E, Andersson, A, Stubelius, A, Krust, A, Chambon, P, Islander, U, Ohlsson, C, Carlsten, H

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Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis by Jochems, C., Islander, U., Erlandsson, M., Engdahl, C., Lagerquist, M., Ohlsson, C., Nandakumar, K. S., Holmdahl, R., Carlsten, H.

“…Summary Oestradiol and the selective oestrogen receptor modulator (SERM) raloxifene have been shown to ameliorate collagen‐induced arthritis (CIA) in rats and…”
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Oestrogen receptor specificity in oestradiol‐mediated effects on B lymphopoiesis and immunoglobulin production in male mice by Erlandsson, M. C., Jonsson, C. A., Islander, U., Ohlsson, C., Carlsten, H.

“…Summary Oestrogen treatment down‐regulates B lymphopoiesis in the bone marrow of mice. Meanwhile it up‐regulates immunoglobulin production. To understand…”
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Estrogenic agonism and antagonism of the soy isoflavone genistein in uterus, bone and lymphopoiesis in mice by ERLANDSSON, M. C., ISLANDER, U., MOVERARE, S., OHLSSON, C., CARLSTEN, H.

“…The isoflavone genistein (Gen) is a naturally occurring phytoestrogen found in high concentrations in soy. The biological effects of Gen have been extensively…”
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17β-Estradiol Expands IgA-Producing B Cells in Mice Deficient for the μ Chain by Lagerquist, M.K, Erlandsson, M.C, Islander, U, Svensson, L, Holmdahl, R, Carlsten, H

“…Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (μ) is essential for B-cell…”
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Influence of oestrogen receptor α and β on the immune system in aged female mice by Islander, U., Erlandsson, M. C., Hasséus, B., Jonsson, C. A., Ohlsson, C., Gustafsson, J‐Å., Dahlgren, U., Carlsten, H.

“…Summary Oestrogen has a dichotomous effect on the immune system. T and B lymphopoiesis in thymus and bone marrow is suppressed, whereas antibody production is…”
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17 beta -Estradiol Expands IgA-Producing B Cells in Mice Deficient for the mu Chain by Lagerquist, M K, Erlandsson, M C, Islander, U, Svensson, L, Holmdahl, R, Carlsten, H

“…Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM ( mu ) is essential for B-cell…”
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Estren‐mediated inhibition of T lymphopoiesis is estrogen receptor‐independent whereas its suppression of T cell‐mediated inflammation is estrogen receptor‐dependent by Islander, U., Erlandsson, M. C., Chavoshi, T., Jochems, C., Movérare, S., Nilsson, S., Ohlsson, C., Gustafsson, J.‐Å., Carlsten, H.

“…Summary Estrogen has extensive effects on the immune system. The aim of the present experiments was to compare the effects of 17β‐estradiol (E2) and…”
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A PHYSIOLOGICAL DOSE OF ESTRADIOL IN A MURINE OSTEOARTHRITIS MODEL PARTIALLY RESCUES THE PHENOTYPE OF THE HEALTHY JOINT by Corciulo, C., Scheffler, J.M., Humeniuk, P., Pons, A. del Carpio, Stubelius, A., Von Mentzer, U., Drevinge, C., Barrett, A., Poutanen, M., Ohlsson, C., Lagerquist, M.K., Islander, U.

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α7 Nicotinic Acetylcholine Receptor Is Expressed in Human Atherosclerosis and Inhibits Disease in Mice—Brief Report by Johansson, Maria E, Ulleryd, Marcus A, Bernardi, Angelina, Lundberg, Anna M, Andersson, Annica, Folkersen, Lasse, Fogelstrand, Linda, Islander, Ulrika, Yan, Zhong-qun, Hansson, Göran K

“…OBJECTIVE—Cholinergic pathways of the autonomic nervous system are known to modulate inflammation. Because atherosclerosis is a chronic inflammatory condition,…”
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Roles of activating functions 1 and 2 of estrogen receptor α in lymphopoiesis by Andersson, Annica, Törnqvist, Anna E, Moverare-Skrtic, Sofia, Bernardi, Angelina I, Farman, Helen H, Chambon, Pierre, Engdahl, Cecilia, Lagerquist, Marie K, Windahl, Sara H, Carlsten, Hans, Ohlsson, Claes, Islander, Ulrika

“…Apart from the role of sex steroids in reproduction, sex steroids are also important regulators of the immune system. 17β-estradiol (E2) represses T and B cell…”
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Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss by Stubelius, Alexandra, Andersson, Annica, Holmdahl, Rikard, Ohlsson, Claes, Islander, Ulrika, Carlsten, Hans

“…Increased reactive oxygen species and estrogen deficiency contribute to the pathophysiology of postmenopausal osteoporosis. Reactive oxygen species contribute…”
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Sex and gender in infection and immunity: addressing the bottlenecks from basic science to public health and clinical applications by Pasin, Chloé, Consiglio, Camila R, Huisman, Jana S, de Lange, Ann-Marie G, Peckham, Hannah, Vallejo-Yagüe, Enriqueta, Abela, Irene A, Islander, Ulrika, Neuner-Jehle, Nadia, Pujantell, Maria, Roth, Olivia, Schirmer, Melanie, Tepekule, Burcu, Zeeb, Marius, Hachfeld, Anna, Aebi-Popp, Karoline, Kouyos, Roger D, Bonhoeffer, Sebastian

“…Although sex and gender are recognized as major determinants of health and immunity, their role is rarely considered in clinical practice and public health. We…”
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The role of activation functions 1 and 2 of estrogen receptor‐α for the effects of estradiol and selective estrogen receptor modulators in male mice by Börjesson, Anna E, Farman, Helen H, Engdahl, Cecilia, Koskela, Antti, Sjögren, Klara, Kindblom, Jenny M, Stubelius, Alexandra, Islander, Ulrika, Carlsten, Hans, Antal, Maria Cristina, Krust, Andrée, Chambon, Pierre, Tuukkanen, Juha, Lagerquist, Marie K, Windahl, Sara H, Ohlsson, Claes

“…Estradiol (E2) is important for male skeletal health and the effect of E2 is mediated via estrogen receptor (ER)‐α. This was demonstrated by the findings that…”
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ERα Signaling in a Subset of CXCL12‐Abundant Reticular Cells Regulates Trabecular Bone in Mice by Scheffler, Julia M, Gustafsson, Karin L, Barrett, Aidan, Corciulo, Carmen, Drevinge, Christina, Del Carpio Pons, Alicia M, Humeniuk, Piotr, Engdahl, Cecilia, Gustafsson, Jan‐Åke, Ohlsson, Claes, Carlsten, Hans, Lagerquist, Marie K., Islander, Ulrika

“…ABSTRACT Estrogen has pronounced effects on the immune system, which also influences bone homeostasis. In recent years, stromal cells in lymphoid organs have…”
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