Search Results - "Islam, Andrew S."

Titanium particles activate toll-like receptor 4 independently of lipid rafts in RAW264.7 murine macrophages by Islam, Andrew S., Beidelschies, Michelle A., Huml, Anne, Greenfield, Edward M.

“…Adherent pathogen‐associated molecular patterns (PAMPs) act through toll‐like receptor 2 (TLR2) and TLR4 to increase the biological activity of orthopedic wear…”
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The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria by Tatro, Joscelyn M., Taki, Naoya, Islam, Andrew S., Goldberg, Victor M., Rimnac, Clare M., Doerschuk, Claire M., Stewart, Matthew C., Greenfield, Edward M.

“…Bacterial endotoxin may contribute to aseptic loosening of orthopedic implants even in the absence of clinical or microbiological evidence of infection. One…”
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Inhibition of the PI3K-Akt Signaling Pathway Reduces Tumor Necrosis Factor-α Production in Response to Titanium Particles in Vitro by Smith, Matthew V., Lee, Michael J., Islam, Andrew S., Rohrer, Jacqueline L., Goldberg, Victor M., Beidelschies, Michelle A., Greenfield, Edward M.

“…Background: Wear debris contributes to implant loosening after total joint arthroplasty, and few advances have been made in our ability to inhibit the…”
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Stimulation of macrophage TNFα production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-κB pathways but is independent of p38 and JNK by Beidelschies, Michelle A., Huang, Honglian, McMullen, Megan R., Smith, Matthew V., Islam, Andrew S., Goldberg, Victor M., Chen, Xin, Nagy, Laura E., Greenfield, Edward M.

“…Bone loss that causes aseptic loosening of orthopedic implants is initiated by pro‐inflammatory cytokines produced by macrophages in response to…”
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Inhibition of the PI3K-Akt Signaling Pathway Reduces Tumor Necrosis Factor-? Production in Response to Titanium Particles in Vitro by Smith, Matthew V., Lee, Michael J., Islam, Andrew S., Rohrer, Jacqueline L., Goldberg, Victor M., Beidelschies, Michelle A., Greenfield, Edward M.

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Inhibition of the PI3K-Akt Signaling Pathway Reduces Tumor Necrosis Factor-α Production in Response to Titanium Particles in Vitro by Smith, Matthew V., MD, Lee, Michael J., MD, Islam, Andrew S., MD, Goldberg, Victor M., MD, Rohrer, Jacqueline L., BS, Beidelschies, Michelle A., BS, Greenfield, Edward M., PhD

“…Background Wear debris contributes to implant loosening after total joint arthroplasty, and few advances have been made in our ability to inhibit the…”
Get full text

Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK by Beidelschies, Michelle A, Huang, Honglian, McMullen, Megan R, Smith, Matthew V, Islam, Andrew S, Goldberg, Victor M, Chen, Xin, Nagy, Laura E, Greenfield, Edward M

“…Bone loss that causes aseptic loosening of orthopedic implants is initiated by pro-inflammatory cytokines produced by macrophages in response to…”
Get full text