Search Results - "Islam, Abul"

Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature by HERRERA, Mercedes, ISLAM, Abul B. M. M. K, BONILLA, Félix, PENA, Cristina, HERRERA, Alberto, MARTIN, Paloma, GARCIA, Vanesa, SILVA, Javier, GARCIA, Jose M, SALAS, Clara, CASAL, Ignacio, GARCIA DE HERREROS, Antonio

“…Cancer-associated fibroblasts (CAF) actively participate in reciprocal communication with tumor cells and with other cell types in the microenvironment,…”
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Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells by Váraljai, Renáta, Islam, Abul B M M K, Beshiri, Michael L, Rehman, Jalees, Lopez-Bigas, Nuria, Benevolenskaya, Elizaveta V

“…The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also…”
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Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer by Aissa, Alexandre F., Islam, Abul B. M. M. K., Ariss, Majd M., Go, Cammille C., Rader, Alexandra E., Conrardy, Ryan D., Gajda, Alexa M., Rubio-Perez, Carlota, Valyi-Nagy, Klara, Pasquinelli, Mary, Feldman, Lawrence E., Green, Stefan J., Lopez-Bigas, Nuria, Frolov, Maxim V., Benevolenskaya, Elizaveta V.

“…Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in…”
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Chromatin-wide Profiling of DYRK1A Reveals a Role as a Gene-Specific RNA Polymerase II CTD Kinase by Di Vona, Chiara, Bezdan, Daniela, Islam, Abul B.M.M.K., Salichs, Eulàlia, López-Bigas, Nuria, Ossowski, Stephan, de la Luna, Susana

“…DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and in tissue homeostasis, and its dysregulation results in human…”
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Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy by Islam, Abul Bashar Mir Md. Khademul, Khan, Md. Abdullah-Al-Kamran

“…An incomplete understanding of the molecular mechanisms behind impairment of lung pathobiology by COVID-19 complicates its clinical management. In this study,…”
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Novel regulation and functional interaction of polycistronic miRNAs by Truscott, Mary, Islam, Abul B M M K, Frolov, Maxim V

“…The importance of microRNAs in gene expression and disease is well recognized. However, what is less appreciated is that almost half of miRNA genes are…”
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Notch signal strength controls cell fate in the haemogenic endothelium by Gama-Norton, Leonor, Ferrando, Eva, Ruiz-Herguido, Cristina, Liu, Zhenyi, Guiu, Jordi, Islam, Abul B. M. M. K., Lee, Sung-Uk, Yan, Minhong, Guidos, Cynthia J., López-Bigas, Nuria, Maeda, Takahiro, Espinosa, Lluis, Kopan, Raphael, Bigas, Anna

“…Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta–gonad–mesonephros (AGM) region prior to haematopoietic stem cell…”
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Association of transcription factor 7-like 2 rs12255372 polymorphism with susceptibility of type 2 diabetes mellitus in Bangladeshi population by Barman, Nilima, Atiqul Haque, Md, Firoz, Mohammuddunobi, Abdullah Yusuf, M., Islam, Abul B. M. M. K.

“…Polymorphism of transcription factor 7-like 2 ( TCF7L2 ) has a link with type 2 diabetes mellitus (T2DM) through β cell dysfunction that causes defect in blood…”
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Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression by de la Rica, Lorenzo, Urquiza, José M, Gómez-Cabrero, David, Islam, Abul B.M.M.K, López-Bigas, Nuria, Tegnér, Jesper, Toes, René E.M, Ballestar, Esteban

“…Abstract Autoimmune rheumatic diseases are complex disorders, whose etiopathology is attributed to a crosstalk between genetic predisposition and environmental…”
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Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence by Guiu, Jordi, Bergen, Dylan J M, De Pater, Emma, Islam, Abul B M M K, Ayllón, Verónica, Gama-Norton, Leonor, Ruiz-Herguido, Cristina, González, Jessica, López-Bigas, Nuria, Menendez, Pablo, Dzierzak, Elaine, Espinosa, Lluis, Bigas, Anna

“…Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements…”
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Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer by Chen, Xinyu, Ariss, Majd M., Ramakrishnan, Gopalakrishnan, Nogueira, Veronique, Blaha, Catherine, Putzbach, William, Islam, Abul B.M.M.K., Frolov, Maxim V., Hay, Nissim

“…Studies in three mouse models of breast cancer identified profound discrepancies between cell-autonomous and systemic Akt1- or Akt2-inducible deletion on…”
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Fenugreek steroidal saponins hinder osteoclastogenic bone resorption by targeting CSF-1R which diminishes the RANKL/OPG ratio by Zinnia, Maliha Afroj, Khademul Islam, Abul Bashar Mir Md

“…Osteoporosis is skeletal fragility caused by the excessive bone resorption due to osteoclastogenesis. But current drugs are less bioavailable and possess…”
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Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer by Kopanja, Dragana, Chand, Vaibhav, O'Brien, Eilidh, Mukhopadhyay, Nishit K, Zappia, Maria P, Islam, Abul B M M K, Frolov, Maxim V, Merrill, Bradley J, Raychaudhuri, Pradip

“…The transcription factor Forkhead box M1 (FoxM1) is overexpressed in breast cancers and correlates with poor prognosis. Mechanistically, FoxM1 associates with…”
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In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development by Azagra, Alba, Román-González, Lidia, Collazo, Olga, Rodríguez-Ubreva, Javier, de Yébenes, Virginia G, Barneda-Zahonero, Bruna, Rodríguez, Jairo, Castro de Moura, Manuel, Grego-Bessa, Joaquim, Fernández-Duran, Irene, Islam, Abul B M M K, Esteller, Manel, Ramiro, Almudena R, Ballestar, Esteban, Parra, Maribel

“…Class IIa histone deacetylase (HDAC) subfamily members are tissue-specific gene repressors with crucial roles in development and differentiation processes. A…”
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Unveiling clinically significant PPARγ mutations for thiazolidinedione treatment responsiveness through atomistic simulations by Shahrear, Sazzad, Islam, Abul Bashar Mir Md. Khademul

“…In Type 2 diabetes, increased insulin sensitivity is induced by thiazolidinedione activation of the peroxisome proliferator-activated receptor gamma (PPARγ)…”
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Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2 by Millán-Ariño, Lluís, Islam, Abul B M M K, Izquierdo-Bouldstridge, Andrea, Mayor, Regina, Terme, Jean-Michel, Luque, Neus, Sancho, Mónica, López-Bigas, Núria, Jordan, Albert

“…Seven linker histone H1 variants are present in human somatic cells with distinct prevalence across cell types. Despite being key structural components of…”
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A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design by Sharmin, Refat, Islam, Abul Bashar Mir Md Khademul

“…Coronaviruses are the diverse group of RNA virus. From 1960, six strains of human coronaviruses have emerged that includes SARS-CoV and the recent infection by…”
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Loss of dE2F Compromises Mitochondrial Function by Ambrus, Aaron M., Islam, Abul B.M.M.K., Holmes, Katherine B., Moon, Nam Sung, Lopez-Bigas, Nuria, Benevolenskaya, Elizaveta V., Frolov, Maxim V.

“…E2F/DP transcription factors regulate cell proliferation and apoptosis. Here, we investigated the mechanism of the resistance of Drosophila dDP mutants to…”
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Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 World-Wide Isolates Delineated the Mystery Behind the Epic Pathogenicity and Distinct Clinical Characteristics of Pandemic COVID-19 by Khan, Md. Abdullah-Al-Kamran, Sany, Md. Rabi Us, Islam, Md. Shafiqul, Islam, Abul Bashar Mir Md. Khademul

“…A detailed understanding of the molecular mechanism of SARS-CoV-2 pathogenesis is still elusive, and there is a need to address its deadly nature and to design…”
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Modeling of MT. P495, an mRNA-based vaccine against the phosphate-binding protein PstS1 of Mycobacterium tuberculosis by Shahrear, Sazzad, Islam, Abul Bashar Mir Md. Khademul

“…Tuberculosis (TB) is a contagious disease that predominantly affects the lungs, but can also spread to other organs via the bloodstream. TB affects about…”
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