Grey and white matter substrates of action naming

Grey and white matter substrates of action naming

Despite a persistent interest in verb processing, data on the neural underpinnings of verb retrieval are fragmentary. The present study is the first to analyze the contributions of both grey and white matter damage affecting verb retrieval through action naming in stroke. We used voxel-based lesion-...

Full description

Saved in:
Bibliographic Details
Published in:Neuropsychologia Vol. 131; pp. 249 - 265
Main Authors: Akinina, Yu, Dragoy, O., Ivanova, M.V., Iskra, E.V., Soloukhina, O.A., Petryshevsky, A.G., Fedinа, O.N., Turken, A.U., Shklovsky, V.M., Dronkers, N.F.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-08-2019
Subjects:
Adult
Aged
Aphasia
Aphasia - diagnostic imaging
Aphasia - etiology
Brain - diagnostic imaging
Female
Gray Matter - diagnostic imaging
Humans
Language
Language Tests
Magnetic Resonance Imaging
Male
Middle Aged
Picture naming
Speech - physiology
Stroke - complications
Stroke - diagnostic imaging
Verbs
VLSM
Vocabulary
White Matter - diagnostic imaging
White-matter tracts
VLSM
Aphasia
White-matter tracts
Picture naming
Verbs
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite a persistent interest in verb processing, data on the neural underpinnings of verb retrieval are fragmentary. The present study is the first to analyze the contributions of both grey and white matter damage affecting verb retrieval through action naming in stroke. We used voxel-based lesion-symptom mapping (VLSM) with an action naming task in 40 left-hemisphere stroke patients. Within the grey matter, we revealed the critical involvement of the left precentral and inferior frontal gyri, insula, and parts of basal ganglia. An overlay of white matter tract probability masks on the VLSM lesion map revealed involvement of left-hemisphere long and short association tracts with terminations in the frontal areas; and several projection tracts. The involvement of these structures is interpreted in the light of existing picture naming models, semantic control processes, and the embodiment cognition framework. Our results stress the importance of both cortico-cortical and cortico-subcortical networks of language processing. •Damage to left frontal areas; insula, and basal ganglia affects action naming.•Action naming relies upon frontal regions involved in word retrieval.•Action naming recruits regions involved in semantic control and motor processing.•Cortico-subcortical networks are critically involved in action naming.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Yu. Akinina: Conceptualization, Methodology, Formal analysis, Investigation, Data curation, Writing - original draft, Visualization, Project administration. O. Dragoy: Conceptualization, Methodology, Writing - review & editing, Supervision, Funding acquisition. M.V. Ivanova: Methodology, Writing - review & editing, Supervision, Funding acquisition. E.V. Iskra: Investigation, Data curation. O.A. Soloukhina: Investigation, Data curation. A.G. Petryshevsky: Investigation, Data curation. O.N. Fedina: Investigation, Data curation. A.U. Turken: Methodology, Software. V.M. Shklovsky: Resources. N.F. Dronkers: Conceptualization, Methodology, Writing - review & editing, Visualization, Supervision, Funding acquisition.
CRediT authorship contribution statement
ISSN:0028-3932
1873-3514
1873-3514
DOI:10.1016/j.neuropsychologia.2019.05.015