Search Results - "Iskow, Rebecca"

Exploring the role of copy number variants in human adaptation by Iskow, Rebecca C, Gokcumen, Omer, Lee, Charles

“…Over the past decade, the ubiquity of copy number variants (CNVs, the gain or loss of genomic material) in the genomes of healthy humans has become apparent…”
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Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons by Iskow, Rebecca C., McCabe, Michael T., Mills, Ryan E., Torene, Spencer, Pittard, W. Stephen, Neuwald, Andrew F., Van Meir, Erwin G., Vertino, Paula M., Devine, Scott E.

“…Two abundant classes of mobile elements, namely Alu and L1 elements, continue to generate new retrotransposon insertions in human genomes. Estimates suggest…”
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Landscape of Somatic Retrotransposition in Human Cancers by Lee, Eunjung, Iskow, Rebecca, Yang, Lixing, Gokcumen, Omer, Haseley, Psalm, Luquette, Lovelace J., Lohr, Jens G., Harris, Christopher C., Ding, Li, Wilson, Richard K., Wheeler, David A., Gibbs, Richard A., Kucherlapati, Raju, Lee, Charles, Kharchenko, Peter V., Park, Peter J.

“…Transposable elements (TEs) are abundant in the human genome, and some are capable of generating new insertions through RNA intermediates. In cancer, the…”
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Which transposable elements are active in the human genome? by Mills, Ryan E, Bennett, E. Andrew, Iskow, Rebecca C, Devine, Scott E

“…Although a large proportion (44%) of the human genome is occupied by transposons and transposon-like repetitive elements, only a small proportion (<0.05%) of…”
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Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division by Abyzov, Alexej, Iskow, Rebecca, Gokcumen, Omer, Radke, David W, Balasubramanian, Suganthi, Pei, Baikang, Habegger, Lukas, Lee, Charles, Gerstein, Mark

“…In primates and other animals, reverse transcription of mRNA followed by genomic integration creates retroduplications. Expressed retroduplications are either…”
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Primate genome architecture influences structural variation mechanisms and functional consequences by Gokcumen, Omer, Tischler, Verena, Tica, Jelena, Zhu, Qihui, Iskow, Rebecca C., Lee, Eunjung, Fritz, Markus Hsi-Yang, Langdon, Amy, Stütz, Adrian M., Pavlidis, Pavlos, Benes, Vladimir, Mills, Ryan E., Park, Peter J., Lee, Charles, Korbel, Jan O.

“…Although nucleotide resolution maps of genomic structural variants (SVs) have provided insights into the origin and impact of phenotypic diversity in humans,…”
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Recently Mobilized Transposons in the Human and Chimpanzee Genomes by Mills, Ryan E., Bennett, E. Andrew, Iskow, Rebecca C., Luttig, Christopher T., Tsui, Circe, Pittard, W. Stephen, Devine, Scott E.

“…Transposable genetic elements are abundant in the genomes of most organisms, including humans. These endogenous mutagens can alter genes, promote genomic…”
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Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence by Gokcumen, Omer, Zhu, Qihui, Mulder, Lubbertus C F, Iskow, Rebecca C, Austermann, Christian, Scharer, Christopher D, Raj, Towfique, Boss, Jeremy M, Sunyaev, Shamil, Price, Alkes, Stranger, Barbara, Simon, Viviana, Lee, Charles

“…Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of…”
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Refinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selection by Gokcumen, Omer, Babb, Paul L, Iskow, Rebecca C, Zhu, Qihui, Shi, Xinghua, Mills, Ryan E, Ionita-Laza, Iuliana, Vallender, Eric J, Clark, Andrew G, Johnson, Welkin E, Lee, Charles

“…Copy number variants (CNVs), defined as losses and gains of segments of genomic DNA, are a major source of genomic variation. In this study, we identified over…”
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Regulatory element copy number differences shape primate expression profiles by Iskow, Rebecca C, Gokcumen, Omer, Abyzov, Alexej, Malukiewicz, Joanna, Zhu, Qihui, Sukumar, Ann T, Pai, Athma A, Mills, Ryan E, Habegger, Lukas, Cusanovich, Darren A, Rubel, Meagan A, Perry, George H, Gerstein, Mark, Stone, Anne C, Gilad, Yoav, Lee, Charles

“…Gene expression differences are shaped by selective pressures and contribute to phenotypic differences between species. We identified 964 copy number…”
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Serological and phylogenetic evidence of monotypic immune responses to different mumps virus strains by Rubin, Steven, Mauldin, Jeremy, Chumakov, Konstantin, Vanderzanden, Jackie, Iskow, Rebecca, Carbone, Kathryn

“…The recent resurgence of mumps epidemics in many countries with ongoing vaccination programs along with evidence of antigenic diversity among mumps virus…”
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Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity by Sauder, Christian J., Vandenburgh, Kari M., Iskow, Rebecca C., Malik, Tahir, Carbone, Kathryn M., Rubin, Steven A.

“…Mumps virus is a highly neurotropic virus with evidence of central nervous system invasion (CNS) in approximately half of all cases of infection. In countries…”
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Increased Genomic Integrity of an Improved Protein‐Based Mouse Induced Pluripotent Stem Cell Method Compared With Current Viral‐Induced Strategies by Park, Hansoo, Kim, Dohoon, Kim, Chun-Hyung, Mills, Ryan E., Chang, Mi-Yoon, Iskow, Rebecca Cheryl, Ko, Sanghyeok, Moon, Jung-Il, Choi, Hyun Woo, Man Yoo, Paulo Sng, Do, Jeong Tae, Han, Min-Joon, Lee, Eun Gyo, Jung, Joon Ki, Zhang, Chengsheng, Lanza, Robert, Kim, Kwang-Soo

“…This study identified an increased copy number variant (CNV) content in lenti‐miPSCs and retro‐miPSCs (29∼53 CNVs) compared with p‐miPSCs (9∼10 CNVs),…”
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Analysis of somatic retrotransposition in human cancers by Lee, Eunjung, Iskow, Rebecca, Yang, Lixing, Gokcumen, Omer, Haseley, Psalm, Luquette, Lovelace J, Lohr, Jens G, Harris, Christopher C, Ding, Li, Wilson, Richard K, Wheeler, David A, Gibbs, Richard A, Kucherlapati, Raju, Lee, Charles, Kharchenko, Peter V, Park, Peter J

“…Doc number: O23…”
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Refinement of primate copy number variationhotspots identifies candidate genomic regions evolving under positive selection by Gokcumen, Omer, Babb, Paul L, Iskow, Rebecca C, Zhu, Qihui, Shi, Xinghua, Mills, Ryan E, Ionita-Laza, Iuliana, Vallender, Eric J, Clark, Andrew G, Johnson, Welkin E, Lee, Charles

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Balancing Selection on a Regulatory Region Exhibiting Ancient Variation That Predates Human-Neandertal Divergence: e1003404 by Gokcumen, Omer, Zhu, Qihui, Mulder, Lubbertus CF, Iskow, Rebecca C, Austermann, Christian, Scharer, Christopher D, Raj, Towfique, Boss, Jeremy M, Sunyaev, Shamil, Price, Alkes, Stranger, Barbara, Simon, Viviana, Lee, Charles

“…Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of…”
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Novel germline and somatic retrotransposon insertions in humans by Iskow, Rebecca C

“…Human genetic variation can cause phenotypic differences as well as provide the substrate for evolutionary forces. Single nucleotide polymorphisms (SNPs) are…”
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