Search Results - "Iskit, Alper B."

Effects of Genetic Polymorphisms of Drug Transporter ABCB1 (MDR1) and Cytochrome P450 Enzymes CYP2A6, CYP2B6 on Nicotine Addiction and Smoking Cessation by Muderrisoglu, Ahmet, Babaoglu, Elif, Korkmaz, Elif Tugce, Ongun, Mert C, Karabulut, Erdem, Iskit, Alper B, Emri, Salih, Babaoglu, Melih O

“…To determine the effects of genetic polymorphisms of ABCB1 (MDR1), CYP2A6, CYP2B6 on smoking status, and clinical outcomes of smoking cessation therapies in a…”
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Dexamethasone effects on vascular flow and organ injury in septic mice by Aytac, Huseyin Ozgur, MD, Iskit, Alper B., MD, Sayek, Iskender, MD

“…Abstract Background To demonstrate the effects of low-dose dexamethasone treatment on mesenteric artery blood flow, oxidative injury, vascular reactivity, and…”
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Antinociceptive, free radical-scavenging, and cytotoxic activities of Acanthus hirsutus Boiss by Harput, Ummuhan Sebnem, Arihan, Okan, Iskit, Alper B, Nagatsu, Akito, Saracoglu, Iclal

“…In vivo antinociceptive and in vitro radical scavenging and cytotoxic activities of Acanthus hirsutus Boiss. aqueous extract were investigated to give a new…”
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Key concepts in biosimilar medicines: What physicians must know by Iskit, Alper B

“…Biologics' are a class of medications produced by living cells using recombinant DNA technology. Biologics have had an important impact in many areas of…”
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The Effects of Lipopolysaccharide Derivatives in Rodent Models of Cardiac Arrhythmia by Yilmaz, Gokhan, Boz, Mustafa, Iskit, Alper B

“…Several previous studies have suggested that sublethal doses of Escherichia coli lipopolysaccharide (endotoxin) and monophosphoryl lipid A Re595, a…”
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Cardioprotective effects of Viscum album L. subsp. album (European misletoe) leaf extracts in myocardial ischemia and reperfusion by Suveren, Eylem, Baxter, Gary F., Iskit, Alper B., Turker, Arzu Ucar

“…Viscum album L. (European mistletoe) is a hemiparasitic plant belonging to Loranthaceae family and has been used in Turkish traditional medicine for the…”
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In vivo evaluation of chitosan based local delivery systems for atorvastatin in treatment of periodontitis by Özdoğan, A. Işılay, İlarslan, Yağmur D., Kösemehmetoğlu, Kemal, Akca, Gülçin, Kutlu, H. Burak, Comerdov, Elnur, Iskit, Alper B., Şenel, Sevda

“…[Display omitted] Periodontitis is a local inflammatory disease initiated by bacteria accumulation and results in cytokine mediated alveolar bone resorption…”
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SP-017 PRODUCTS SITUATION OF THE BIOSIMILARS IN TURKEY AND IN THE WORLD by Iskit, Alper B

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Endothelin receptor antagonist bosentan improves survival in a murine caecal ligation and puncture model of septic shock by Iskit, Alper B., Senel, Isil, Sokmensuer, Cenk, Guc, M. Oguz

“…The role of endothelin peptides was evaluated on survival and organ injury in a model of polymicrobial sepsis, induced by caecal ligation and puncture with…”
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Determination and validation of aprepitant in rat plasma using LC−MS/MS by Erdoğar, Nazlı, Reçber, Tuba, İskit, Alper B, Bilensoy, Erem, Kır, Sedef, Nemutlu, Emirhan

“…The assessment of efficacy should be paralleled with extensive pharmacokinetic parameters, and a valid bioanalytical method is a pre-condition for accurate…”
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Improved oral bioavailability of anticancer drug tamoxifen through complexation with water soluble cyclodextrins: in vitro and in vivo evaluation by Erdoğar, Nazlı, Nemutlu, Emirhan, İskit, Alper B., Kara, S. Cihan, Teksin, Zeynep Şafak, Bilensoy, Erem

“…Tamoxifen (TMX), a class II antiestrogen drug consistent with the biopharmaceutical classification system, shows low plasma levels leading to therapeutic…”
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Tezosentan Attenuates Organ Injury and Mesenteric Blood Flow Decrease in Endotoxemia and Cecal Ligation and Puncture by Erdem, Aysen, M.D, Meltem Sevgili, A., M.D, Akbiyik, Filiz, M.D., Ph.D, Atilla, Pergin, M.D., Ph.D, Cakar, Nur, Ph.D, Balkanci, Z. Dicle, M.D, Iskit, Alper B., M.D, Guc, M. Oguz, M.D., Ph.D

“…Background Decreased mesenteric blood flow and multiple organ injury due to free radicals are the consequences of septic shock. Since the blockade of…”
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Effects of ATP-sensitive potassium channel blockers on vascular hyporeactivity, mesenteric blood flow, and survival in lipopolysaccharide-induced septic shock model by Boz, Mustafa, Atilla, Pergin, Iskit, Alper B, Ilhan, Mustafa

“…In this study, the possible therapeutic effects of various ATP-sensitive potassium channel (KATP) blockers (glibenclamide, repaglinide, 5-HD, HMR-1098) have…”
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Antitumor Efficacy of Bacillus Calmette-Guerin Loaded Cationic Nanoparticles for Intravesical Immunotherapy of Bladder Tumor Induced Rat Model by Erdoğar, Nazli, Iskit, Alper B, Eroğlu, Hakan, Sargon, Mustafa F, Mungan, N Aydin, Bilensoy, Erem

“…For bladder cancer, intravesical chemo/immunotherapy is widely used as adjuvant therapy after surgical transurethral resection. Bacillus Calmette-Guerin (BCG)…”
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The effect of coniine on presynaptic nicotinic receptors by Erkent, Ulkem, Iskit, Alper B., Onur, Rustu, Ilhan, Mustafa

“…Toxicity of coniine, an alkaloid of (poison hemlock), is manifested by characteristic nicotinic clinical signs including excitement, depression, hypermetria,…”
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Antinociceptive activity of coniine in mice by Arihan, Okan, Boz, Mustafa, Iskit, Alper B., Ilhan, Mustafa

“…Hemlock was used as an analgesic in certain ethnopharmacological traditions and there has been no record about the antinociceptive effect of coniine which is…”
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Chitosan delivery systems for the treatment of oral mucositis: in vitro and in vivo studies by Aksungur, Pelin, Sungur, Arzu, Ünal, Serhat, İskit, Alper B, Squier, Christopher A, Şenel, Sevda

“…Oral mucositis is a frequent and potentially severe complication of radiation or chemotherapy for cancer. Associated with atrophy and ulceration of the oral…”
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The effects of bosentan, aminoguanidine and l-canavanine on mesenteric blood flow, spleen and liver in endotoxaemic mice by Iskit, Alper B, Sungur, Arzu, Gedikoglu, Gokhan, Oguz Guc, M

“…The modulatory effects of a non-selective endothelin receptor antagonist, bosentan, were investigated together with those of relatively selective inducible…”
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Comparison of endothelin and nitric oxide synthase blockers on hemorheological parameters in endotoxemic rats by Dikmenoğlu Falkmarken, Neslihan H, Arihan, Okan, Iskit, Alper B

“…Septic shock is an important health problem that vastly alters cardiovascular and hemodynamic status. Increased production of nitric oxide (NO) and endothelin…”
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Prolonged retention and in vivo evaluation of cationic nanoparticles loaded with Mitomycin C designed for intravesical chemotherapy of bladder tumours by Erdo ar, Nazl, skit, Alper B., Mungan, N. Ayd n, Bilensoy, Erem

“…To overcome the recurrence problem in bladder tumours; nanoparticles with positive surface charge may improve interaction with biological membranes for…”
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