Search Results - "Iskander, Deena"

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways by Psaila, Bethan, Barkas, Nikolaos, Iskander, Deena, Roy, Anindita, Anderson, Stacie, Ashley, Neil, Caputo, Valentina S, Lichtenberg, Jens, Loaiza, Sandra, Bodine, David M, Karadimitris, Anastasios, Mead, Adam J, Roberts, Irene

“…Recent advances in single-cell techniques have provided the opportunity to finely dissect cellular heterogeneity within populations previously defined by…”
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The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma by Ponnusamy, Kanagaraju, Tzioni, Maria Myrsini, Begum, Murshida, Robinson, Mark E, Caputo, Valentina S, Katsarou, Alexia, Trasanidis, Nikolaos, Xiao, Xiaolin, Kostopoulos, Ioannis V, Iskander, Deena, Roberts, Irene, Trivedi, Pritesh, Auner, Holger W, Naresh, Kikkeri, Chaidos, Aristeidis, Karadimitris, Anastasios

“…Multiple myeloma is a malignancy of plasma cells initiated and driven by primary and secondary genetic events. However, myeloma plasma cell survival and…”
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Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development by Roy, Anindita, Wang, Guanlin, Iskander, Deena, O’Byrne, Sorcha, Elliott, Natalina, O’Sullivan, Jennifer, Buck, Gemma, Heuston, Elisabeth F., Wen, Wei Xiong, Meira, Alba Rodriguez, Hua, Peng, Karadimitris, Anastasios, Mead, Adam J., Bodine, David M., Roberts, Irene, Psaila, Bethan, Thongjuea, Supat

“…Human hematopoiesis is a dynamic process that starts in utero 18–21 days post-conception. Understanding the site- and stage-specific variation in hematopoiesis…”
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Two’s company but three’s a blast by Iskander, Deena

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P332: LIN28B: AN IMPORTANT ONCO‐FETAL GENE IN INFANT ACUTE LYMPHOBLASTIC LEUKAEMIA by Ling, Rebecca, Jackson, Thomas, Elliott, Natalina, Cross, Joe, Rice, Siobhan, Howitt, Rebecca, Smith, Alastair, Harman, Joe, T Crump, Nicholas, Wang, Guanlin, Iskander, Deena, Thongjuea, Supat, Ancliff, Philip, Psaila, Beth, Roberts, Irene, Milne, Thomas, Roy, Anindita

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1011 – INVESTIGATION OF HUMAN BONE MARROW PROGENITORS ELUCIDATES CELLULAR AND MOLECULAR MECHANISMS OF ERYTHROID FAILURE IN DIAMOND-BLACKFAN ANEMIA by Iskander, Deena

“…Ribosome dysfunction underlies the pathogenesis of many cancers and heritable ribosomopathies. Diamond-Blackfan anemia (DBA) is a rare bone marrow failure…”
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Harnessing Single-Cell Technologies in the Search for New Therapies for Diamond–Blackfan Anemia Syndrome by Iskander, Deena, Karadimitris, Anastasios, Roberts, Irene

“…•Diamond–Blackfan anemia syndrome (DBA) is an inherited anemia caused by heterozygous ribosomal protein gene variants.•Single-cell RNA sequencing (ScRNA-seq)…”
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1011 – INVESTIGATION OF HUMAN BONE MARROW PROGENITORS ELUCIDATES CELLULAR AND MOLECULAR MECHANISMS OF ERYTHROID FAILURE IN DIAMOND-BLACKFAN ANEMIA by Iskander, Deena

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Turning up the HEAT(R3) in Diamond-Blackfan anemia by Iskander, Deena, Warren, Alan J.

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Harnessing Single-Cell Technologies in the Search for New Therapies for Diamond-Blackfan Anemia by Iskander, Deena, Karadimitris, Anastasios, Roberts, Irene

“…The emergence of multiomic single-cell technologies over the last decade has led to improved insights into both normal hematopoiesis and its perturbation in a…”
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Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets by Psaila, Bethan, Wang, Guanlin, Rodriguez-Meira, Alba, Li, Rong, Heuston, Elisabeth F, Murphy, Lauren, Yee, Daniel, Hitchcock, Ian S, Sousos, Nikolaos, O'Sullivan, Jennifer, Anderson, Stacie, Senis, Yotis A, Weinberg, Olga K, Calicchio, Monica L, Iskander, Deena, Royston, Daniel, Milojkovic, Dragana, Roberts, Irene, Bodine, David M, Thongjuea, Supat, Mead, Adam J

“…Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers of abnormal bone marrow megakaryocytes that induce fibrosis,…”
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Impaired cellular and humoral immunity is a feature of Diamond‐Blackfan anaemia; experience of 107 unselected cases in the United Kingdom by Iskander, Deena, Roberts, Irene, Rees, Clare, Szydlo, Richard, Alikian, Mary, Neale, Michael, Harrington, Yvonne, Kelleher, Peter, Karadimitris, Anastasios, Fuente, Josu

“…Summary Diamond‐Blackfan anaemia (DBA) is a rare bone marrow failure syndrome characterised by anaemia, congenital anomalies and cancer predisposition…”
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Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia by Louka, Eleni, Povinelli, Benjamin, Rodriguez-Meira, Alba, Buck, Gemma, Wen, Wei Xiong, Wang, Guanlin, Sousos, Nikolaos, Ashley, Neil, Hamblin, Angela, Booth, Christopher A G, Roy, Anindita, Elliott, Natalina, Iskander, Deena, de la Fuente, Josu, Fordham, Nicholas, O'Byrne, Sorcha, Inglott, Sarah, Norfo, Ruggiero, Salio, Mariolina, Thongjuea, Supat, Rao, Anupama, Roberts, Irene, Mead, Adam J

“…Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is…”
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Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia by Iskander, Deena, Wang, Guanlin, Heuston, Elisabeth F, Christodoulidou, Chrysi, Psaila, Bethan, Ponnusamy, Kanagaraju, Ren, Hongwei, Mokhtari, Zeinab, Robinson, Mark, Chaidos, Aristeidis, Trivedi, Pritesh, Trasanidis, Nikolaos, Katsarou, Alexia, Szydlo, Richard, Palii, Carmen G, Zaidi, Mehmood H, Al-Oqaily, Qais, Caputo, Valentina S, Roy, Anindita, Harrington, Yvonne, Karnik, Leena, Naresh, Kikkeri, Mead, Adam J, Thongjuea, Supat, Brand, Marjorie, de la Fuente, Josu, Bodine, David M, Roberts, Irene, Karadimitris, Anastasios

“…Ribosome dysfunction underlies the pathogenesis of many cancers and heritable ribosomopathies. Here, we investigate how mutations in either ribosomal protein…”
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Diamond-Blackfan anemia in adults: In pursuit of a common approach for a rare disease by Iskander, Deena, Roy, Noémi B.A., Payne, Elspeth, Drasar, Emma, Hennessy, Kelly, Harrington, Yvonne, Christodoulidou, Chrysi, Karadimitris, Anastasios, Batkin, Leisa, de la Fuente, Josu

“…Diamond-Blackfan anemia (DBA) is a rare bone marrow failure syndrome, usually caused by loss-of function variants in genes encoding ribosomal proteins. The…”
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3159 – A SINGLE-CELL PROTEIN-TRANSCRIPTOME ATLAS OF HAEMATOPOIESIS ACROSS THE HUMAN LIFESPAN by Londoño, Mariana Quiroga, Mende, Nicole, Stephenson, Emily, Iskander, Deena, Isobe, Tomoya, Webb, Simone, Goh, Issac, Shanmugiah, Vijaya Mahalingam, Hannah, Rebecca, Roy, Anindita, Roberts, Irene, Laurenti, Elisa, Haniffa, Muzlifah, Wilson, Nicola K, Göttgens, Berthold

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3166 – A PROTEIN‐TRANSCRIPTOME ATLAS OF HAEMATOPOIESIS ACROSS THE HUMAN LIFESPAN by Londoño, Mariana Quiroga, Mende, Nicole, Stephenson, Emily, Iskander, Deena, Webb, Simone, Goh, Issac, Shanmugiah, Vijaya Mahalingam, Roy, Anindita, Roberts, Irene, Laurenti, Elisa, Haniffa, Muzlifah, Wilson, Nicola K, Göttgens, Berthold

“…Human haematopoiesis differs substantially across the lifespan, presumably as an adaptation to the changing demands and physiological requirements. The blood…”
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Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs by Iskander, Deena, Psaila, Bethan, Gerrard, Gareth, Chaidos, Aristeidis, En Foong, Hui, Harrington, Yvonne, Karnik, Leena C., Roberts, Irene, de la Fuente, Josu, Karadimitris, Anastasios

“…Diamond-Blackfan anemia (DBA) is a disorder characterized by a selective defect in erythropoiesis. Delineation of the precise defect is hampered by a lack of…”
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Novel ZBP1-IRF3 Dependency in Multiple Myeloma Mediated By IRF3-Driven Regulation of Cell Cycle Genes by Ponnusamy, Kanagaraju, Tzioni, Maria-Myrsini, Begum, Murshida, Robinson, Mark E, Caputo, Valentina S, Katsarou, Alexia, Trasanidis, Nikolaos, Xiao, Xiaolin, Kostopoulos, Ioannis V., Iskander, Deena, Roberts, Irene, Trivedi, Pritesh, Auner, Holger W, Naresh, Kikkeri, Chaidos, Aristeidis, Karadimitris, Anastasios

“…ZBP1 is an inducible nucleic acid (NA) sensor that is activated when pathogen NA bind to its Zα and Zβ domains. ZBP1 is required for TBK1-dependent…”
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Single-Cell Transcriptional Landscapes of Human Bone Marrow Reveal Distinct Erythroid Phenotypes Underpinned By Genotype in Diamond-Blackfan Anemia by Iskander, Deena, Wang, Guanlin, Heuston, Elisabeth F, Christodoulidou, Chrysi, Psaila, Bethan, Robinson, Mark E, Chaidos, Aristeidis, Trivedi, Pritesh, Trasanidis, Nikolaos, Katsarou, Alexia, Szydlo, Richard, SequencingProgram, NISC Comparative, Al-Oqaily, Qais, Caputo, Valentina S, Ponnusamy, Kanagaraju, Roy, Anindita, Karnik, Leena, Naresh, Kikkeri, Mead, Adam J., Thongjuea, Supat, Brand, Marjorie, de la Fuente, Josu, Bodine, David M., Roberts, Irene, Karadimitris, Anastasios

“…Background: Diamond- Blackfan Anemia (DBA) is a rare, heritable ribosomopathy caused by mutations in ribosomal protein large (RPL) and small (RPS) subunit…”
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