Search Results - "Iskandar, Anita R"

An in vitro evaluation of e-vapor products: The contributions of chemical adulteration, concentration, and device power by Johne, Stephanie, van der Toorn, Marco, Iskandar, Anita R., Majeed, Shoaib, Torres, Laura O., Hoeng, Julia, Peitsch, Manuel C.

“…Homemade e-liquids and power-adjustable vaping devices may carry higher risks than commercial formulations and fixed-power devices. This study used human…”
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β-Cryptoxanthin Reduced Lung Tumor Multiplicity and Inhibited Lung Cancer Cell Motility by Downregulating Nicotinic Acetylcholine Receptor α7 Signaling by Iskandar, Anita R, Miao, Benchun, Li, Xinli, Hu, Kang-Quan, Liu, Chun, Wang, Xiang-Dong

“…Despite the consistent association between a higher intake of the provitamin A carotenoid β-cryptoxanthin (BCX) and a lower risk of lung cancer among smokers,…”
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Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts by Iskandar, Anita R, Xiang, Yang, Frentzel, Stefan, Talikka, Marja, Leroy, Patrice, Kuehn, Diana, Guedj, Emmanuel, Martin, Florian, Mathis, Carole, Ivanov, Nikolai V, Peitsch, Manuel C, Hoeng, Julia

“…Organotypic 3D cultures of epithelial cells are grown at the air-liquid interface (ALI) and resemble the in vivo counterparts. Although the complexity of…”
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Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures by Zanetti, Filippo, Sewer, Alain, Mathis, Carole, Iskandar, Anita R, Kostadinova, Radina, Schlage, Walter K, Leroy, Patrice, Majeed, Shoaib, Guedj, Emmanuel, Trivedi, Keyur, Martin, Florian, Elamin, Ashraf, Merg, Céline, Ivanov, Nikolai V, Frentzel, Stefan, Peitsch, Manuel C, Hoeng, Julia

“…Cigarette smoke (CS) has been reported to increase predisposition to oral cancer and is also recognized as a risk factor for many conditions including…”
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Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures by Giralt, Albert, Iskandar, Anita R, Martin, Florian, Moschini, Elisa, Serchi, Tomasso, Kondylis, Athanasios, Marescotti, Diego, Leroy, Patrice, Ortega-Torres, Laura, Majeed, Shoaib, Merg, Celine, Trivedi, Keyur, Guedj, Emmanuel, Frentzel, Stefan, Ivanov, Nikolai V., Peitsch, Manuel C, Gutleb, Arno C, Hoeng, Julia

“…[Display omitted] •Biological impact of exposure to an aerosol of an e-vapor device was investigated using human bronchial and alveolar models.•The biological…”
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Assessment of in vitro kinetics and biological impact of nebulized trehalose on human bronchial epithelium by Iskandar, Anita R., Kolli, Aditya Reddy, Giralt, Albert, Neau, Laurent, Fatarova, Maria, Kondylis, Athanasios, Torres, Laura Ortega, Majeed, Shoaib, Merg, Celine, Corciulo, Maica, Trivedi, Keyur, Guedj, Emmanuel, Frentzel, Stefan, Calvino, Florian, Guy, Philippe Alexandre, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Trehalose is added in drug formulations to act as fillers or improve aerosolization performance. Its characteristics as a carrier molecule have been explored;…”
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Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens by Zanetti, Filippo, Sewer, Alain, Scotti, Elena, Titz, Bjoern, Schlage, Walter K., Leroy, Patrice, Kondylis, Athanasios, Vuillaume, Gregory, Iskandar, Anita R., Guedj, Emmanuel, Trivedi, Keyur, Schneider, Thomas, Elamin, Ashraf, Martin, Florian, Frentzel, Stefan, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may…”
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A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures by Iskandar, Anita R., Mathis, Carole, Schlage, Walter K., Frentzel, Stefan, Leroy, Patrice, Xiang, Yang, Sewer, Alain, Majeed, Shoaib, Ortega-Torres, Laura, Johne, Stephanie, Guedj, Emmanuel, Trivedi, Keyur, Kratzer, Gilles, Merg, Celine, Elamin, Ashraf, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…This study reports a comparative assessment of the biological impact of a heated tobacco aerosol from the tobacco heating system (THS) 2.2 and smoke from a…”
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Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology by Iskandar, Anita R., Zanetti, Filippo, Marescotti, Diego, Titz, Bjorn, Sewer, Alain, Kondylis, Athanasios, Leroy, Patrice, Belcastro, Vincenzo, Torres, Laura Ortega, Acali, Stefano, Majeed, Shoaib, Steiner, Sandro, Trivedi, Keyur, Guedj, Emmanuel, Merg, Celine, Schneider, Thomas, Frentzel, Stefan, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…We previously proposed a systems toxicology framework for in vitro assessment of e-liquids. The framework starts with the first layer aimed at screening the…”
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Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment by Iskandar, Anita R., Martin, Florian, Leroy, Patrice, Schlage, Walter K., Mathis, Carole, Titz, Bjorn, Kondylis, Athanasios, Schneider, Thomas, Vuillaume, Grégory, Sewer, Alain, Guedj, Emmanuel, Trivedi, Keyur, Elamin, Ashraf, Frentzel, Stefan, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…The biological impact of an aerosol of a potential modified-risk tobacco product, carbon heated tobacco product 1.2 (CHTP1.2), was comprehensively assessed for…”
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Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues by Peitsch, Manuel C., Mathis, Carole, Kostadinova, Radina, Schlage, Walter K., Talikka, Marja, Martin, Florian, Iskandar, Anita R., Hoeng, Julia

“…Capturing the effects of exposure in a specific target organ is a major challenge in risk assessment. Exposure to cigarette smoke (CS) implicates the field of…”
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A framework for in vitro systems toxicology assessment of e-liquids by Iskandar, Anita R., Gonzalez-Suarez, Ignacio, Majeed, Shoaib, Marescotti, Diego, Sewer, Alain, Xiang, Yang, Leroy, Patrice, Guedj, Emmanuel, Mathis, Carole, Schaller, Jean-Pierre, Vanscheeuwijck, Patrick, Frentzel, Stefan, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Various electronic nicotine delivery systems (ENDS), of which electronic cigarettes (e-cigs) are the most recognized prototype, have been quickly gaining…”
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3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product by Iskandar, Anita R, Mathis, Carole, Martin, Florian, Leroy, Patrice, Sewer, Alain, Majeed, Shoaib, Kuehn, Diana, Trivedi, Keyur, Grandolfo, Davide, Cabanski, Maciej, Guedj, Emmanuel, Merg, Celine, Frentzel, Stefan, Ivanov, Nikolai V, Peitsch, Manuel C, Hoeng, Julia

“…In vitro toxicology approaches have evolved from a focus on molecular changes within a cell to understanding of toxicity-related mechanisms in systems that can…”
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A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment by Iskandar, Anita R., Zanetti, Filippo, Kondylis, Athanasios, Martin, Florian, Leroy, Patrice, Majeed, Shoaib, Steiner, Sandro, Xiang, Yang, Ortega Torres, Laura, Trivedi, Keyur, Guedj, Emmanuel, Merg, Celine, Frentzel, Stefan, Ivanov, Nikolai V., Doshi, Utkarsh, Lee, Kyeonghee Monica, McKinney, Willie J., Peitsch, Manuel C., Hoeng, Julia

“…In the context of tobacco harm-reduction strategy, the potential reduced impact of electronic cigarette (EC) exposure should be evaluated relative to the…”
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Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures by Zanetti, Filippo, Sewer, Alain, Titz, Bjoern, Schlage, Walter K., Iskandar, Anita R., Kondylis, Athanasios, Leroy, Patrice, Guedj, Emmanuel, Trivedi, Keyur, Elamin, Ashraf, Martin, Florian, Frentzel, Stefan, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Swedish snus is a smokeless tobacco product that contains reduced levels of harmful compounds compared with cigarette smoke. In Sweden, where snus use exceeds…”
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β-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice by ISKANDAR, Anita R, CHUN LIU, SMITH, Donald E, HU, Kang-Quan, CHOI, Sang-Woon, AUSMAN, Lynne M, WANG, Xiang-Dong

“…Nicotine, a large constituent of cigarette smoke, is associated with an increased risk of lung cancer, but the data supporting this relationship are…”
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In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures by Schlage, Walter K., Iskandar, Anita R., Kostadinova, Radina, Xiang, Yang, Sewer, Alain, Majeed, Shoaib, Kuehn, Diana, Frentzel, Stefan, Talikka, Marja, Geertz, Marcel, Mathis, Carole, Ivanov, Nikolai, Hoeng, Julia, Peitsch, Manuel C.

“…Abstract Smoking has been associated with diseases of the lung, pulmonary airways and oral cavity. Cytologic, genomic and transcriptomic changes in oral mucosa…”
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Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach by Iskandar, Anita R, Martinez, Yannick, Martin, Florian, Schlage, Walter K, Leroy, Patrice, Sewer, Alain, Torres, Laura Ortega, Majeed, Shoaib, Merg, Celine, Trivedi, Keyur, Guedj, Emmanuel, Frentzel, Stefan, Mathis, Carole, Ivanov, Nikolai V, Peitsch, Manuel C, Hoeng, Julia

“…Using an human small airway epithelium model, we assessed the biological impact of an aerosol from a candidate modified-risk tobacco product, the tobacco…”
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A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products by Sewer, Alain, Zanetti, Filippo, Iskandar, Anita R., Guedj, Emmanuel, Dulize, Remi, Peric, Dariusz, Bornand, David, Mathis, Carole, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…[Display omitted] •This meta-analysis evaluated 12 miRNA expression datasets from aerodigestive tissues.•Treatments included cigarette smoke (CS) and…”
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Modulations of sirtuin 1 protein levels by nicotine and β‐ cryptoxanthin can be mediated by miR‐34a in A/J mice lung cancer model by Iskandar, Anita R, You, Min, Wang, Xiang‐Dong

“…Abstract only MicroRNAs (miRs) are small endogenous non‐coding RNAs that can regulate gene expression in a post‐transcriptional manner and target important…”
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