Search Results - "Ising, M."

Cognitive impairment in unipolar depression is persistent and non-specific: further evidence for the final common pathway disorder hypothesis by Reppermund, S, Ising, M, Lucae, S, Zihl, J

“…Cognitive performance is often impaired in depression, and these impairments can persist even after remission from psychopathological symptoms. However, it is…”
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Evidence for the role of corticotropin-releasing factor in major depressive disorder by Waters, R Parrish, Rivalan, Marion, Bangasser, D A, Deussing, J M, Ising, M, Wood, S K, Holsboer, F, Summers, Cliff H

“…Major depressive disorder (MDD) is a devastating disease affecting over 300 million people worldwide, and costing an estimated 380 billion Euros in lost…”
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Salivary cortisol response to psychosocial stress in the late evening depends on CRHR1 genotype by Weeger, J., Ising, M., Müller-Myhsok, B., Uhr, M., Schmidt, U., Steiger, A.

“…•Variants of CRHR1 rs110402 reveal different cortisol response after psychosocial stress.•Rare homozygous T carrier of CRHR1 rs110402 have significant higher…”
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FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications by Gassen, N C, Hartmann, J, Zannas, A S, Kretzschmar, A, Zschocke, J, Maccarrone, G, Hafner, K, Zellner, A, Kollmannsberger, L K, Wagner, K V, Mehta, D, Kloiber, S, Turck, C W, Lucae, S, Chrousos, G P, Holsboer, F, Binder, E B, Ising, M, Schmidt, M V, Rein, T

“…Psychotropic medications target glycogen synthase kinase 3β (GSK3β), but the functional integration with other factors relevant for drug efficacy is poorly…”
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Depression, comorbidities and the TNF-α system by Himmerich, H, Fulda, S, Linseisen, J, Seiler, H, Wolfram, G, Himmerich, S, Gedrich, K, Kloiber, S, Lucae, S, Ising, M, Uhr, M, Holsboer, F, Pollmächer, T

“…Abstract Depression has frequently been reported to be associated with other physical diseases and changes in the cytokine system. We aimed to investigate…”
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Ghrelin promotes slow-wave sleep in humans by Weikel, J C, Wichniak, A, Ising, M, Brunner, H, Friess, E, Held, K, Mathias, S, Schmid, D A, Uhr, M, Steiger, A

“…Ghrelin, an endogenous ligand of the growth hormone (GH) secretagogue (GHS) receptor, stimulates GH release, appetite, and weight gain in humans and rodents…”
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Working conditions and mental health – results from a longitudinal epidemiological survey by Ising, M, Belcredi, P, Zimmermann, P, Pfister, H, Holsboer, F

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Increased prevalence of anxiety-associated personality traits in patients with Cushing's disease: a cross-sectional study by Dimopoulou, C, Ising, M, Pfister, H, Schopohl, J, Stalla, G K, Sievers, C

“…Chronic hypercortisolism in Cushing's disease (CD) has been suggested to contribute to an altered personality profile in these patients. We aimed to test this…”
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Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin–proteasome systems by Park, D I, Dournes, C, Sillaber, I, Ising, M, Asara, J M, Webhofer, C, Filiou, M D, Müller, M B, Turck, C W

“…The aim of this study was to identify molecular pathways related to antidepressant response. We administered paroxetine to the DBA/2J mice for 28 days…”
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HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients by Binder, E.B, Künzel, H.E, Nickel, T, Kern, N, Pfennig, A, Majer, M, Uhr, M, Ising, M, Holsboer, F

“…Summary A concatenation of data implicates a hyperactivity of the hypothalamus pituitary adrenal (HPA)-axis in the pathogenesis of depression and its…”
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Updated results from a phase II study of infigratinib (BGJ398), a selective pan-FGFR kinase inhibitor, in patients with previously treated advanced cholangiocarcinoma containing FGFR2 fusions by Javle, M., Kelley, R.K., Roychowdhury, S., Weiss, K.H., Abou-Alfa, G.K., Macarulla, T., Sadeghi, S., Waldschmidt, D., Zhu, A.X., Goyal, L., Borad, M., Yong, W.P., Borbath, I., El-Khoueiry, A., Philip, P., Moran, S., Ye, Y., Ising, M., Lewis, N., Bekaii-Saab, T.

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Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders by Majer, M, Ising, M, Künzel, H, Binder, E B, Holsboer, F, Modell, S, Zihl, J

“…This study addresses the complex relationship between cognitive function and the course of depression. A sample of patients (n=73) in a depressive episode…”
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Time experience and time judgment in major depression, mania and healthy subjects. A controlled study of 93 subjects by Bschor, T., Ising, M., Bauer, M., Lewitzka, U., Skerstupeit, M., Müller-Oerlinghausen, B., Baethge, C.

“…Objective:  Studies on the time sense of depressed patients have revealed inconsistent results. Manic patients have been almost neglected. Method:  Patients…”
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Specific behaviour, mood and personality traits may contribute to obesity in patients with craniopharyngioma by Roemmler-Zehrer, J., Geigenberger, V., Störmann, S., Ising, M., Pfister, H., Sievers, C., Stalla, G.K., Schopohl, J.

“…Summary Introduction Patients with craniopharyngioma (CP) often suffer from obesity, but the underlying causes are still not fully understood. We compared CP…”
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A phase I trial of LHC165 single agent and in combination with spartalizumab in patients with advanced solid malignancies by Curigliano, G., Jimenez, M.M., Shimizu, T., Keam, B., Meric-Bernstam, F., Rutten, A., Glaspy, J., Schuler, P.J., Parikh, N.S., Ising, M., Hassounah, N., Wu, J., Leyk, M., Chen, X., Burks, H., Chaudhury, A., Otero, J., Cabanas, E.Garralda

“…LHC165 is a Toll-like receptor (TLR)-7 agonist that generates an effective tumor antigen-specific T-cell adaptive immune response as well as durable antitumor…”
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RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response by Hennings, J M, Uhr, M, Klengel, T, Weber, P, Pütz, B, Touma, C, Czamara, D, Ising, M, Holsboer, F, Lucae, S

“…Response to antidepressant treatment is highly variable with some patients responding within a few weeks, whereas others have to wait for months until the…”
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Familiality and SNP heritability of age at onset and episodicity in major depressive disorder by Ferentinos, P, Koukounari, A, Power, R, Rivera, M, Uher, R, Craddock, N, Owen, M J, Korszun, A, Jones, L, Jones, I, Gill, M, Rice, J P, Ising, M, Maier, W, Mors, O, Rietschel, M, Preisig, M, Binder, E B, Aitchison, K J, Mendlewicz, J, Souery, D, Hauser, J, Henigsberg, N, Breen, G, Craig, I W, Farmer, A E, Müller-Myhsok, B, McGuffin, P, Lewis, C M

“…Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO)…”
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Personality in patients with pituitary adenomas is characterized by increased anxiety-related traits: comparison of 70 acromegalic patients with patients with non-functioning pituitary adenomas and age- and gender-matched controls by Sievers, C, Ising, M, Pfister, H, Dimopoulou, C, Schneider, H J, Roemmler, J, Schopohl, J, Stalla, G K

“…ObjectiveAlthough neuropsychiatric and morphological brain alterations in acromegalic patients have been described and a distinct disease personality is…”
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Estimating the heritability of reporting stressful life events captured by common genetic variants by Power, R A, Wingenbach, T, Cohen-Woods, S, Uher, R, Ng, M Y, Butler, A W, Ising, M, Craddock, N, Owen, M J, Korszun, A, Jones, L, Jones, I, Gill, M, Rice, J P, Maier, W, Zobel, A, Mors, O, Placentino, A, Rietschel, M, Lucae, S, Holsboer, F, Binder, E B, Keers, R, Tozzi, F, Muglia, P, Breen, G, Craig, I W, Müller-Myhsok, B, Kennedy, J L, Strauss, J, Vincent, J B, Lewis, C M, Farmer, A E, McGuffin, P

“…Although usually thought of as external environmental stressors, a significant heritable component has been reported for measures of stressful life events…”
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Subsided infections and autoimmune events in narcolepsy by Beitinger, P, Ising, M, Kohl, G, Steiger, A

“…Introduction Narcolepsy is a rare sleep–wake disorder characterized by excessive daytime sleepiness with imperative sleep attacks and cataplexy. In the vast…”
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