Enhanced production of lovastatin by Omphalotus olearius (DC.) Singer in solid state fermentation

Enhanced production of lovastatin by Omphalotus olearius (DC.) Singer in solid state fermentation

Abstract Background Although lovastatin production has been reported for different microorganism species, there is limited information about lovastatin production by basidiomycetes. Aims The optimization of culture parameters that enhances lovastatin production by Omphalotus olearius OBCC 2002 was i...

Full description

Saved in:
Bibliographic Details
Published in:Revista iberoamericana de micologia Vol. 32; no. 4; pp. 247 - 251
Main Authors: Atlı, Burcu, Yamaç, Mustafa, Yıldız, Zeki, Isikhuemnen, Omoanghe S
Format: Journal Article
Language:English
Published: Spain Elsevier Espana 01-10-2015
Subjects:
Agaricales - metabolism
Avena
Culture Media
Dietary Fiber
Diseño estadístico
Fermentación en estado sólido
Fermentation
Hordeum
Industrial Microbiology - methods
Infectious Disease
Lactose - pharmacology
Lovastatin
Lovastatin - biosynthesis
Lovastatina
Models, Biological
Mycology - methods
Omphalotus olearius
Optimización
Optimization
Oryza
Solid state fermentation
Statistical modeling
Trace Elements - pharmacology
Zea mays
Statistical modeling
Diseño estadístico
Optimización
Solid state fermentation
Omphalotus olearius
Lovastatin
Lovastatina
Optimization
Fermentación en estado sólido
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Although lovastatin production has been reported for different microorganism species, there is limited information about lovastatin production by basidiomycetes. Aims The optimization of culture parameters that enhances lovastatin production by Omphalotus olearius OBCC 2002 was investigated, using statistically based experimental designs under solid state fermentation. Methods The Plackett Burman design was used in the first step to test the relative importance of the variables affecting production of lovastatin. Amount and particle size of barley were identified as efficient variables. In the latter step, the interactive effects of selected efficient variables were studied with a full factorial design. Results A maximum lovastatin yield of 139.47 mg/g substrate was achieved by the fermentation of 5 g of barley, 1–2 mm particle diam., at 28 °C. Conclusions This study showed that O. olearius OBCC 2002 has a high capacity for lovastatin production which could be enhanced by using solid state fermentation with novel and cost-effective substrates, such as barley.
ISSN:1130-1406
2173-9188
DOI:10.1016/j.riam.2014.06.008