Search Results - "Ishiuchi, Kan’ichiro"

Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats by Tanimura, Yohei, Yoshida, Masato, Ishiuchi, Kan'ichiro, Ohsawa, Masahiro, Makino, Toshiaki

“…Processed aconite root (PA), the root of Aconitum carmichaeli (Ranunculaceae), is a crude drug used in traditional Chinese or Japanese kampo medicine to treat…”
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Combinatorial Generation of Complexity by Redox Enzymes in the Chaetoglobosin A Biosynthesis by Ishiuchi, Kan’ichiro, Nakazawa, Takehito, Yagishita, Fumitoshi, Mino, Takashi, Noguchi, Hiroshi, Hotta, Kinya, Watanabe, Kenji

“…Redox enzymes play a central role in generating structural complexity during natural product biosynthesis. In the postassembly tailoring steps, redox cascades…”
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Involvement of cardiac glycosides targeting Na/K-ATPase in their inhibitory effects on c-Myc expression via its transcription, translation and proteasomal degradation by Tokugawa, Muneshige, Inoue, Yasumichi, Aoki, Hiromasa, Miyajima, Chiharu, Ishiuchi, Kan'ichiro, Tsurumi, Kento, Kujirai, Chisane, Morishita, Daisuke, Matsuno, Michiyo, Mizukami, Hajime, Ri, Masaki, Iida, Shinsuke, Makino, Toshiaki, Aoyama, Mineyoshi, Hayashi, Hidetoshi

“…Abstract Cardiac glycosides (CGs) have been used for decades to treat heart failure and arrhythmic diseases. Recent non-clinical and epidemiological findings…”
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Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products by Tsunematsu, Yuta, Ishiuchi, Kan'ichiro, Hotta, Kinya, Watanabe, Kenji

“…In this article, we review recent successful efforts to engineer biosynthesis of several important fungal natural products through heterologous expression of…”
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Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice by Nakatani, Yoshihiko, Negoro, Kanako, Yamauchi, Miki, Katasho, Maki, Ishikura, Kei-ichiro, Iwaki, Anna, Tsukada, Kazuyo, Yamaguchi, Marina, Uehara, Arata, Yoshida, Masato, Ishiuchi, Kan'ichiro, Makino, Toshiaki, Kitajima, Masaki, Ohsawa, Masahiro, Amano, Taku

“…Goshajinkigan (GJG), a traditional Japanese Kampo formula, has been shown to exhibit several pharmacological actions, including antinociceptive effects…”
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Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301 by Ishiuchi, Kan'ichiro, Hirose, Dai, Kondo, Taishi, Watanabe, Kohei, Terasaka, Kazuyoshi, Makino, Toshiaki

“…[Display omitted] •Mariannamides A (1) and B (2), new cyclic octapeptides, were isolated from Mariannaea elegans NBRC102301.•The absolute configurations of 1…”
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Identification of Lycopodium Alkaloids Produced by an Ultraviolet-Irradiated Strain of Paraboeremia, an Endophytic Fungus from Lycopodium serratum var. longipetiolatum by Ishiuchi, Kan’ichiro, Hirose, Dai, Suzuki, Takuma, Nakayama, Waka, Jiang, Wen-Ping, Monthakantirat, Orawan, Wu, Jin-Bin, Kitanaka, Susumu, Makino, Toshiaki

“…12-epi-Lycopodine (1), a Lycopodium alkaloid, along with lycopodine (2) and huperzine A (3), were discovered in the mycelium of Paraboeremia sp. Lsl3KI076, a…”
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Interactions between crude drug extracts used in Japanese traditional Kampo medicines and organic anion-transporting polypeptide 2B1 by Iijima, Rie, Watanabe, Tomoki, Ishiuchi, Kan'ichiro, Matsumoto, Takashi, Watanabe, Junko, Makino, Toshiaki

“…The use of herbal medicines has become popular worldwide, and the information on drug interactions between herbal medicines and chemical drugs is needed. We…”
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Stereochemistries of Mariannamides C and D, Two Lipohexapeptides, Isolated from Mariannaea elegans NBRC102301 by Ishiuchi, Kan'ichiro, Nagumo, Akiho, Kawaguchi, Mitsuyasu, Furuyashiki, Honoka, Nakagawa, Hidehiko, Hirose, Dai

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Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro by Ishiuchi, Kan’ichiro, Park, Jeong-Jin, Long, Robert M., Gang, David R.

“…LC–IMS–MS analysis of Huperzia species grown under controlled conditions sheds light on the regulation of Lycopodium alkaloid biosynthesis. H. pinifolia callus…”
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Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum by Ishiuchi, Kan’ichiro, Kubota, Takaaki, Ishiyama, Haruaki, Hayashi, Shigeki, Shibata, Toshiro, Mori, Koichiro, Obara, Yutaro, Nakahata, Norimichi, Kobayashi, Jun’ichi

“…Three new Lycopodium alkaloids, lyconadins D ( 1) and E ( 2), and complanadine E ( 3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (…”
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Establishing a New Methodology for Genome Mining and Biosynthesis of Polyketides and Peptides through Yeast Molecular Genetics by Ishiuchi, Kan'ichiro, Nakazawa, Takehito, Ookuma, Takashi, Sugimoto, Satoru, Sato, Michio, Tsunematsu, Yuta, Ishikawa, Noriyasu, Noguchi, Hiroshi, Hotta, Kinya, Moriya, Hisao, Watanabe, Kenji

“…Fungal genome sequencing has revealed many genes coding for biosynthetic enzymes, including polyketide synthases and nonribosomal peptide synthetases. However,…”
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Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker by Ishiuchi, Kan'ichiro, Morinaga, Osamu, Yoshino, Tetsuhiro, Mitamura, Miaki, Hirasawa, Asuka, Maki, Yasuhito, Tashita, Yuuna, Kondo, Tsubasa, Ogawa, Kakuyou, Lian, Fangyi, Ogawa-Ochiai, Keiko, Minamizawa, Kiyoshi, Namiki, Takao, Mimura, Masaru, Watanabe, Kenji, Makino, Toshiaki

“…Liquorice is usually used as crude drug in traditional Japanese Kampo medicine and traditional Chinese medicine. Liquorice-containing glycyrrhizin (GL) can…”
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Isochromophilol A, a New Azaphilone Isolated from Penicillium sp. RO369, a Leaf Litter Inhabiting Fungus from Tsuga diversifolia by Ishiuchi, Kan'ichiro, Kitanaka, Susumu, Hirose, Dai, Takahashi, Yoriko, Miyagawa, Ryu, Watanabe, Kohei

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Overexpressing Transcriptional Regulator in Aspergillus oryzae Activates a Silent Biosynthetic Pathway to Produce a Novel Polyketide by Nakazawa, Takehito, Ishiuchi, Kan'ichiro, Praseuth, Alex, Noguchi, Hiroshi, Hotta, Kinya, Watanabe, Kenji

“…Fungal genomes carry many gene clusters seemingly capable of natural product biosynthesis, yet most clusters remain silent. This places a major constraint on…”
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Serralongamine A, a New Lycopodium Alkaloid from Lycopodium serratum var. longipetiolatum by Wu, Jin-Bin, Kitanaka, Susumu, Ishiuchi, Kan'ichiro, Jiang, Wen-Ping

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Isolation and characterization of a novel glucosyltransferase involved in production of emodin-6-O-glucoside and rhaponticin in Rheum palmatum by Yamada, Aki, Kondo-Kaneko, Miku, Ishiuchi, Kan’ichiro, Makino, Toshiaki, Terasaka, Kazuyoshi

“…Anthraquinones are widely distributed in various organisms and known as bioactive ingredients. Some of the anthraquinones accumulate as glycosides in higher…”
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Honey isomaltose contributes to the induction of granulocyte-colony stimulating factor (G-CSF) secretion in the intestinal epithelial cells following honey heating by Xu, Xin, Asai, Koshi, Kato, Daiki, Ishiuchi, Kan’ichiro, Ding, Kewen, Tabuchi, Yoshiaki, Ota, Misato, Makino, Toshiaki

“…We have previously discovered that heated honey but not unheated honey could induce the secretion of granulocyte-colony stimulating factor (G-CSF) in the…”
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Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients by Kondo, Taishi, Ishida, Tomoaki, Ye, Ke, Muraguchi, Marin, Tanimura, Yohei, Yoshida, Masato, Ishiuchi, Kan’ichiro, Abe, Tomoki, Nikawa, Takeshi, Hagihara, Keisuke, Hayashi, Hidetoshi, Makino, Toshiaki

“…Processed aconite root (PA), the tuberous root of Aconitum carmichaelii prepared by autoclaving, is a crude drug used in Japanese traditional Kampo medicine…”
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Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study by Takahashi, Kanon, Yoshino, Tetsuhiro, Maki, Yasuhito, Ishiuchi, Kan’ichiro, Namiki, Takao, Ogawa-Ochiai, Keiko, Minamizawa, Kiyoshi, Makino, Toshiaki, Nakamura, Tomonori, Mimura, Masaru, Watanabe, Kenji

“…Liquorice [main ingredient, glycyrrhizin (GL)] is widely used as a food sweetener and herbal medicine. Occasionally, liquorice consumption causes…”
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